Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes Mellitus
Relevance. Patients with diabetes mellitus have an increased risk of developing various infections, including those of the lower respiratory tract. Immunization with anti-pneumococcal vaccines reduces pneumonia-related hospitalizations and deaths.Aim. Evaluate the cost-effectiveness of vaccination a...
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Numikom LLC
2022-11-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/1677 |
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| author | A. V. Rudakova N. I. Briko Yu. V. Lobzin I. S. Namazova-Baranova S. N. Avdeev V. A. Korshunov M. P. Kostinov G. I. Ignatova E. V. Blinova A. V. Kontsevaya R. V. Shepel I. Yu. Drozdova O. M. Drapkina |
| author_facet | A. V. Rudakova N. I. Briko Yu. V. Lobzin I. S. Namazova-Baranova S. N. Avdeev V. A. Korshunov M. P. Kostinov G. I. Ignatova E. V. Blinova A. V. Kontsevaya R. V. Shepel I. Yu. Drozdova O. M. Drapkina |
| author_sort | A. V. Rudakova |
| collection | DOAJ |
| description | Relevance. Patients with diabetes mellitus have an increased risk of developing various infections, including those of the lower respiratory tract. Immunization with anti-pneumococcal vaccines reduces pneumonia-related hospitalizations and deaths.Aim. Evaluate the cost-effectiveness of vaccination against pneumococcal infection in 40and 65-year-old patients with type 2 diabetes mellitus (DM2).Material and methods. The analysis was carried out from the perspective of the healthcare system. The Markov model based on Russian epidemiological data, taking into account the results of foreign studies, was used. Vaccination schedules with 1 dose of 13-valent pneumococcal conjugate vaccine (PCV13) followed by 1 dose of pneumococcal 23-valent polysaccharide vaccine (PPV23) and vaccination with only 1 dose of PCV13 were evaluated. The time horizon of the study is 5 years. Costs and life expectancy were discounted by 3.5% per year.Results. Vaccination of 65-year-old patients with type 2 diabetes is characterized by extremely high cost-effectiveness (the incremental cost effectiveness ratio – ICER – for PCV13+PPV23 vaccination is 189.27 thousand rubles/QALY, and PCV13 vaccination entails a cost reduction of 371.92 rubles per 1 vaccinated). When vaccinating 40-year-old patients, the ICER for PCV13 + PPV23 vaccination is 491.31 thousand rubles/QALY, and for PCV13 – 55.31 thousand rubles/QALY.Conclusion. Vaccination against pneumococcal disease in 40and 65-year-old patients with DM2 reduces the associated morbidity and mortality and is highly cost-effective. Compared to PCV13 vaccination alone, vaccination with PCV13 followed by the introduction of PPV23 provides an increase in the number of prevented cases of the disease and the deaths caused by it, but at the same time requires additional costs. |
| format | Article |
| id | doaj-art-97b4b8fcdfd544fd9cbc17028df96921 |
| institution | Kabale University |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| publishDate | 2022-11-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj-art-97b4b8fcdfd544fd9cbc17028df969212025-08-20T03:34:39ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942022-11-01215788810.31631/2073-3046-2022-21-5-78-88879Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes MellitusA. V. Rudakova0N. I. Briko1Yu. V. Lobzin2I. S. Namazova-Baranova3S. N. Avdeev4V. A. Korshunov5M. P. Kostinov6G. I. Ignatova7E. V. Blinova8A. V. Kontsevaya9R. V. Shepel10I. Yu. Drozdova11O. M. Drapkina12Federal State-Financed Institution Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency; Saint Petersburg State Chemical and Pharmaceutical UniversityI. M. Sechenov First Moscow State Medical University (Sechenov University)Federal State-Financed Institution Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency; North-Western State Medical University named after I. I. MechnikovPirogov Russian National Research Medical University; Research Institute of Pediatrics and Child Health at the Central Clinical Hospital of the Russian Academy of SciencesResearch Institute of Pulmonology under the Federal Medical Biological AgencyI. M. Sechenov First Moscow State Medical University (Sechenov University)I. M. Sechenov First Moscow State Medical University (Sechenov University); Research Institute of Vaccines and Serums named after I.I. MechnikovSouth Ural State Medical UniversitySouth Ural State Medical UniversityFederal State Institution «National Medical Research Center for Preventive Medicine»Federal State Institution «National Medical Research Center for Preventive Medicine»Federal State Institution «National Medical Research Center for Preventive Medicine»Federal State Institution «National Medical Research Center for Preventive Medicine»Relevance. Patients with diabetes mellitus have an increased risk of developing various infections, including those of the lower respiratory tract. Immunization with anti-pneumococcal vaccines reduces pneumonia-related hospitalizations and deaths.Aim. Evaluate the cost-effectiveness of vaccination against pneumococcal infection in 40and 65-year-old patients with type 2 diabetes mellitus (DM2).Material and methods. The analysis was carried out from the perspective of the healthcare system. The Markov model based on Russian epidemiological data, taking into account the results of foreign studies, was used. Vaccination schedules with 1 dose of 13-valent pneumococcal conjugate vaccine (PCV13) followed by 1 dose of pneumococcal 23-valent polysaccharide vaccine (PPV23) and vaccination with only 1 dose of PCV13 were evaluated. The time horizon of the study is 5 years. Costs and life expectancy were discounted by 3.5% per year.Results. Vaccination of 65-year-old patients with type 2 diabetes is characterized by extremely high cost-effectiveness (the incremental cost effectiveness ratio – ICER – for PCV13+PPV23 vaccination is 189.27 thousand rubles/QALY, and PCV13 vaccination entails a cost reduction of 371.92 rubles per 1 vaccinated). When vaccinating 40-year-old patients, the ICER for PCV13 + PPV23 vaccination is 491.31 thousand rubles/QALY, and for PCV13 – 55.31 thousand rubles/QALY.Conclusion. Vaccination against pneumococcal disease in 40and 65-year-old patients with DM2 reduces the associated morbidity and mortality and is highly cost-effective. Compared to PCV13 vaccination alone, vaccination with PCV13 followed by the introduction of PPV23 provides an increase in the number of prevented cases of the disease and the deaths caused by it, but at the same time requires additional costs.https://www.epidemvac.ru/jour/article/view/1677pneumoniavaccinationtype 2 diabetescost-effectiveness |
| spellingShingle | A. V. Rudakova N. I. Briko Yu. V. Lobzin I. S. Namazova-Baranova S. N. Avdeev V. A. Korshunov M. P. Kostinov G. I. Ignatova E. V. Blinova A. V. Kontsevaya R. V. Shepel I. Yu. Drozdova O. M. Drapkina Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes Mellitus Эпидемиология и вакцинопрофилактика pneumonia vaccination type 2 diabetes cost-effectiveness |
| title | Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes Mellitus |
| title_full | Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes Mellitus |
| title_fullStr | Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes Mellitus |
| title_full_unstemmed | Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes Mellitus |
| title_short | Cost-Effectiveness of Pneumococcal Vaccination among Patients with Diabetes Mellitus |
| title_sort | cost effectiveness of pneumococcal vaccination among patients with diabetes mellitus |
| topic | pneumonia vaccination type 2 diabetes cost-effectiveness |
| url | https://www.epidemvac.ru/jour/article/view/1677 |
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