The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study
Background. Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective. We investigated whether IgM memory B-cells cou...
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Wiley
2023-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2023/5863995 |
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| author | Bente M. Houtman Iris Walraven Elke de Grouw Richard W. M. van der Maazen Leontien C. M. Kremer Eline van Dulmen-den Broeder Marry M. van den Heuvel-Eibrink Wim J. E. Tissing Dorine Bresters Helena J. H. van der Pal Andrica C. H. de Vries Marloes Louwerens Margriet van der Heiden-van der Loo Sebastian J. C. Neggers Geert O. Janssens Nicole M. A. Blijlevens Annechien J. A. Lambeck Frank Preijers Jacqueline J. Loonen |
| author_facet | Bente M. Houtman Iris Walraven Elke de Grouw Richard W. M. van der Maazen Leontien C. M. Kremer Eline van Dulmen-den Broeder Marry M. van den Heuvel-Eibrink Wim J. E. Tissing Dorine Bresters Helena J. H. van der Pal Andrica C. H. de Vries Marloes Louwerens Margriet van der Heiden-van der Loo Sebastian J. C. Neggers Geert O. Janssens Nicole M. A. Blijlevens Annechien J. A. Lambeck Frank Preijers Jacqueline J. Loonen |
| author_sort | Bente M. Houtman |
| collection | DOAJ |
| description | Background. Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective. We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the spleen, or TBI. Methods. All CCS were enrolled from the DCCSS-LATER cohort. We analyzed differences in IgM memory B-cells and Howell–Jolly bodies (HJB) in CCS who had a splenectomy (n = 9), received radiotherapy involving the spleen (n = 36), or TBI (n = 15). IgM memory B-cells < 9 cells/µL was defined as abnormal. Results. We observed a higher median number of IgM memory B-cells in CCS who received radiotherapy involving the spleen (31 cells/µL, p=0.06) or TBI (55 cells/µL, p = 0.03) compared to CCS who received splenectomy (20 cells/µL). However, only two CCS had IgM memory B-cells below the lower limit of normal. No difference in IgM memory B-cells was observed between CCS with HJB present and absent (35 cells/µL vs. 44 cells/µL). Conclusion. Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction. |
| format | Article |
| id | doaj-art-97aeb6763b8e4f25b1e9bd538ec21d67 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-97aeb6763b8e4f25b1e9bd538ec21d672025-02-03T06:45:14ZengWileyJournal of Immunology Research2314-71562023-01-01202310.1155/2023/5863995The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER StudyBente M. Houtman0Iris Walraven1Elke de Grouw2Richard W. M. van der Maazen3Leontien C. M. Kremer4Eline van Dulmen-den Broeder5Marry M. van den Heuvel-Eibrink6Wim J. E. Tissing7Dorine Bresters8Helena J. H. van der Pal9Andrica C. H. de Vries10Marloes Louwerens11Margriet van der Heiden-van der Loo12Sebastian J. C. Neggers13Geert O. Janssens14Nicole M. A. Blijlevens15Annechien J. A. Lambeck16Frank Preijers17Jacqueline J. Loonen18Department of HematologyDepartment for Health EvidenceDepartment of Laboratory Medicine—Radboudumc Laboratory of DiagnosticsDepartment of RadiotherapyPrincess Máxima Center for Pediatric OncologyDepartment of Pediatric Oncology/HematologyPrincess Máxima Center for Pediatric OncologyDepartment of Pediatric Oncology/HematologyPrincess Máxima Center for Pediatric OncologyPrincess Máxima Center for Pediatric OncologyDepartment of Pediatric OncologyDepartment of Internal MedicinePrincess Máxima Center for Pediatric OncologyDepartment of Medicine, Section EndocrinologyDepartment of Radiation OncologyDepartment of HematologyDepartment of Laboratory MedicineDepartment of Laboratory Medicine—Laboratory for HematologyDepartment of HematologyBackground. Childhood cancer survivors (CCS) who received radiotherapy involving the spleen or total body irradiation (TBI) might be at risk for splenic dysfunction. A comprehensive screening test for examining splenic dysfunction is lacking. Objective. We investigated whether IgM memory B-cells could be used to assess splenic dysfunction in CCS who received a splenectomy, radiotherapy involving the spleen, or TBI. Methods. All CCS were enrolled from the DCCSS-LATER cohort. We analyzed differences in IgM memory B-cells and Howell–Jolly bodies (HJB) in CCS who had a splenectomy (n = 9), received radiotherapy involving the spleen (n = 36), or TBI (n = 15). IgM memory B-cells < 9 cells/µL was defined as abnormal. Results. We observed a higher median number of IgM memory B-cells in CCS who received radiotherapy involving the spleen (31 cells/µL, p=0.06) or TBI (55 cells/µL, p = 0.03) compared to CCS who received splenectomy (20 cells/µL). However, only two CCS had IgM memory B-cells below the lower limit of normal. No difference in IgM memory B-cells was observed between CCS with HJB present and absent (35 cells/µL vs. 44 cells/µL). Conclusion. Although the number of IgM memory B-cells differed between splenectomized CCS and CCS who received radiotherapy involving the spleen or TBI, only two CCS showed abnormal values. Therefore, this assessment cannot be used to screen for splenic dysfunction.http://dx.doi.org/10.1155/2023/5863995 |
| spellingShingle | Bente M. Houtman Iris Walraven Elke de Grouw Richard W. M. van der Maazen Leontien C. M. Kremer Eline van Dulmen-den Broeder Marry M. van den Heuvel-Eibrink Wim J. E. Tissing Dorine Bresters Helena J. H. van der Pal Andrica C. H. de Vries Marloes Louwerens Margriet van der Heiden-van der Loo Sebastian J. C. Neggers Geert O. Janssens Nicole M. A. Blijlevens Annechien J. A. Lambeck Frank Preijers Jacqueline J. Loonen The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study Journal of Immunology Research |
| title | The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study |
| title_full | The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study |
| title_fullStr | The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study |
| title_full_unstemmed | The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study |
| title_short | The Value of IgM Memory B-Cells in the Assessment of Splenic Function in Childhood Cancer Survivors at Risk for Splenic Dysfunction: A DCCSS-LATER Study |
| title_sort | value of igm memory b cells in the assessment of splenic function in childhood cancer survivors at risk for splenic dysfunction a dccss later study |
| url | http://dx.doi.org/10.1155/2023/5863995 |
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