Cerebellar metastasis from colorectal cancer: a case report
IntroductionColorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with adenocarcinoma as the most common subtype. While metastasis typically occurs in the liver, lungs, and peritoneal cavity, metastasis to the brain, particularly the cerebellum, is exceedingly rare.Case p...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1519441/full |
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| author | Carla E. Angulo-Rojo Luis J. Castillo-Gaxiola Karen Gaxiola-Gastélum Alma M. Guadrón-Llanos Javier A. Magaña-Gómez Diana L. Baldenebro-Félix Diana L. Baldenebro-Félix |
| author_facet | Carla E. Angulo-Rojo Luis J. Castillo-Gaxiola Karen Gaxiola-Gastélum Alma M. Guadrón-Llanos Javier A. Magaña-Gómez Diana L. Baldenebro-Félix Diana L. Baldenebro-Félix |
| author_sort | Carla E. Angulo-Rojo |
| collection | DOAJ |
| description | IntroductionColorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with adenocarcinoma as the most common subtype. While metastasis typically occurs in the liver, lungs, and peritoneal cavity, metastasis to the brain, particularly the cerebellum, is exceedingly rare.Case presentationThis report discusses the case of a 50-year-old woman diagnosed with mucinous adenocarcinoma of the descending colon. Over six years, the patient experienced multiple common metastatic sites, including the liver and lungs, before developing a rare cerebellar metastasis. Despite extensive treatment, including surgery and chemotherapy, the disease progressed, ultimately leading to the patient’s demise. This case represents the first documented cerebellar metastasis from CRC in Mexico.ConclusionThis case highlights the altered metastatic patterns in CRC due to advanced therapies that extend survival. Clinicians should remain vigilant for metastasis to uncommon sites, such as the cerebellum, especially in patients with prolonged survival. Further research is needed to understand the mechanisms underlying such metastatic behavior and optimize treatment strategies. |
| format | Article |
| id | doaj-art-97ab35bcafb74d5f938b51aef0ecde17 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-97ab35bcafb74d5f938b51aef0ecde172025-01-24T05:21:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.15194411519441Cerebellar metastasis from colorectal cancer: a case reportCarla E. Angulo-Rojo0Luis J. Castillo-Gaxiola1Karen Gaxiola-Gastélum2Alma M. Guadrón-Llanos3Javier A. Magaña-Gómez4Diana L. Baldenebro-Félix5Diana L. Baldenebro-Félix6Laboratorio de Neurociencias, Centro de Investigación Aplicada a la Salud Pública (CIASaP), Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, MexicoLaboratorio de Neurociencias, Centro de Investigación Aplicada a la Salud Pública (CIASaP), Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, MexicoLaboratorio de Neurociencias, Centro de Investigación Aplicada a la Salud Pública (CIASaP), Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, MexicoLaboratorio de Diabetes y Comorbilidades, Centro de Investigación Aplicada a la Salud Pública (CIASaP), Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, MexicoLaboratorio de Nutrición Molecular, Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, MexicoLaboratorio de Neurociencias, Centro de Investigación Aplicada a la Salud Pública (CIASaP), Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, MexicoPrograma de Posgrado en Biomedicina Molecular, Facultad de Medicina, Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, MexicoIntroductionColorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with adenocarcinoma as the most common subtype. While metastasis typically occurs in the liver, lungs, and peritoneal cavity, metastasis to the brain, particularly the cerebellum, is exceedingly rare.Case presentationThis report discusses the case of a 50-year-old woman diagnosed with mucinous adenocarcinoma of the descending colon. Over six years, the patient experienced multiple common metastatic sites, including the liver and lungs, before developing a rare cerebellar metastasis. Despite extensive treatment, including surgery and chemotherapy, the disease progressed, ultimately leading to the patient’s demise. This case represents the first documented cerebellar metastasis from CRC in Mexico.ConclusionThis case highlights the altered metastatic patterns in CRC due to advanced therapies that extend survival. Clinicians should remain vigilant for metastasis to uncommon sites, such as the cerebellum, especially in patients with prolonged survival. Further research is needed to understand the mechanisms underlying such metastatic behavior and optimize treatment strategies.https://www.frontiersin.org/articles/10.3389/fonc.2025.1519441/fullcase reportcolorectal cancercolonic adenocarcinomacerebellar metastasistumor markers |
| spellingShingle | Carla E. Angulo-Rojo Luis J. Castillo-Gaxiola Karen Gaxiola-Gastélum Alma M. Guadrón-Llanos Javier A. Magaña-Gómez Diana L. Baldenebro-Félix Diana L. Baldenebro-Félix Cerebellar metastasis from colorectal cancer: a case report Frontiers in Oncology case report colorectal cancer colonic adenocarcinoma cerebellar metastasis tumor markers |
| title | Cerebellar metastasis from colorectal cancer: a case report |
| title_full | Cerebellar metastasis from colorectal cancer: a case report |
| title_fullStr | Cerebellar metastasis from colorectal cancer: a case report |
| title_full_unstemmed | Cerebellar metastasis from colorectal cancer: a case report |
| title_short | Cerebellar metastasis from colorectal cancer: a case report |
| title_sort | cerebellar metastasis from colorectal cancer a case report |
| topic | case report colorectal cancer colonic adenocarcinoma cerebellar metastasis tumor markers |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1519441/full |
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