Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma
The isolation from brain tumors of tumor mesenchymal stem-like cells (tMSLCs) suggests that these cells play a role in creating a microenvironment for tumor initiation and progression. The clinical characteristics of patients with primary glioblastoma (pGBM) positive for tMSLCs have not been determi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/6756983 |
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| author | Seon-Jin Yoon Jin-Kyoung Shim Jong Hee Chang Ju Hyung Moon Tae-Hoon Roh Kyoung Su Sung Ji-Hyun Lee Eui-Hyun Kim Sun Ho Kim Yong-Kil Hong Su-Jae Lee Yong-Min Huh Seok-Gu Kang |
| author_facet | Seon-Jin Yoon Jin-Kyoung Shim Jong Hee Chang Ju Hyung Moon Tae-Hoon Roh Kyoung Su Sung Ji-Hyun Lee Eui-Hyun Kim Sun Ho Kim Yong-Kil Hong Su-Jae Lee Yong-Min Huh Seok-Gu Kang |
| author_sort | Seon-Jin Yoon |
| collection | DOAJ |
| description | The isolation from brain tumors of tumor mesenchymal stem-like cells (tMSLCs) suggests that these cells play a role in creating a microenvironment for tumor initiation and progression. The clinical characteristics of patients with primary glioblastoma (pGBM) positive for tMSLCs have not been determined. This study analyzed samples from 82 patients with pGBM who had undergone tumor removal, pathological diagnosis, and isolation of tMSLC from April 2009 to October 2014. Survival, extent of resection, molecular markers, and tMSLC culture results were statistically evaluated. Median overall survival was 18.6 months, 15.0 months in tMSLC-positive patients and 29.5 months in tMSLC-negative patients (P=0.014). Multivariate cox regression model showed isolation of tMSLC (OR = 2.5, 95% CI = 1.1~5.6, P=0.021) showed poor outcome while larger extent of resection (OR = 0.5, 95% CI = 0.2~0.8, P=0.011) has association with better outcome. The presence of tMSLCs isolated from the specimen of pGBM is associated with the survival of patient. |
| format | Article |
| id | doaj-art-97aaecebcecf4072bb801ddad7d61f56 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-97aaecebcecf4072bb801ddad7d61f562025-02-03T05:58:48ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/67569836756983Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary GlioblastomaSeon-Jin Yoon0Jin-Kyoung Shim1Jong Hee Chang2Ju Hyung Moon3Tae-Hoon Roh4Kyoung Su Sung5Ji-Hyun Lee6Eui-Hyun Kim7Sun Ho Kim8Yong-Kil Hong9Su-Jae Lee10Yong-Min Huh11Seok-Gu Kang12Department of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Seoul St. Mary’s Hospital, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 137-701, Republic of KoreaDepartment of Life Science, Hanyang University, 17 Haendang-dong, Seongdong-gu, Seoul 133-791, Republic of KoreaDepartment of Radiology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaDepartment of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of KoreaThe isolation from brain tumors of tumor mesenchymal stem-like cells (tMSLCs) suggests that these cells play a role in creating a microenvironment for tumor initiation and progression. The clinical characteristics of patients with primary glioblastoma (pGBM) positive for tMSLCs have not been determined. This study analyzed samples from 82 patients with pGBM who had undergone tumor removal, pathological diagnosis, and isolation of tMSLC from April 2009 to October 2014. Survival, extent of resection, molecular markers, and tMSLC culture results were statistically evaluated. Median overall survival was 18.6 months, 15.0 months in tMSLC-positive patients and 29.5 months in tMSLC-negative patients (P=0.014). Multivariate cox regression model showed isolation of tMSLC (OR = 2.5, 95% CI = 1.1~5.6, P=0.021) showed poor outcome while larger extent of resection (OR = 0.5, 95% CI = 0.2~0.8, P=0.011) has association with better outcome. The presence of tMSLCs isolated from the specimen of pGBM is associated with the survival of patient.http://dx.doi.org/10.1155/2016/6756983 |
| spellingShingle | Seon-Jin Yoon Jin-Kyoung Shim Jong Hee Chang Ju Hyung Moon Tae-Hoon Roh Kyoung Su Sung Ji-Hyun Lee Eui-Hyun Kim Sun Ho Kim Yong-Kil Hong Su-Jae Lee Yong-Min Huh Seok-Gu Kang Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma Stem Cells International |
| title | Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma |
| title_full | Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma |
| title_fullStr | Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma |
| title_full_unstemmed | Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma |
| title_short | Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma |
| title_sort | tumor mesenchymal stem like cell as a prognostic marker in primary glioblastoma |
| url | http://dx.doi.org/10.1155/2016/6756983 |
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