Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem
Historically, the following two methods were used to treat gestational diabetes mellitus: non-medical life-style interventions (diet and increased physical activity) and insulin treatment when other interventions were not effective. The possibility of alternative types of treatment such as oral anti...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2016-05-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/7797 |
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| author | Anna I. Sazonova Roza M. Esayan Oksana I. Kolegaeva Zhanna R. Gardanova |
| author_facet | Anna I. Sazonova Roza M. Esayan Oksana I. Kolegaeva Zhanna R. Gardanova |
| author_sort | Anna I. Sazonova |
| collection | DOAJ |
| description | Historically, the following two methods were used to treat gestational diabetes mellitus: non-medical life-style interventions (diet and increased physical activity) and insulin treatment when other interventions were not effective. The possibility of alternative types of treatment such as oral anti-diabetic drugs has been the source of debate in recent years. Metformin is an oral anti-diabetic drug that reduces insulin resistance, which is common during gestation and is considered one of the main pathways of glucose metabolism alteration during pregnancy. The main concern is that metformin can cross the placenta and is found unchanged in foetal blood. This is the reason why oral anti-diabetic drugs are contraindicated during pregnancy in many countries, including Russia (according to the 2012 Russian recommendations for gestational diabetes treatment). In recent years, many studies investigating the safety and efficacy of metformin for maternal and foetal health have been published. We will review recent randomized clinical trials and discuss new international clinical recommendations (FIGO, 2015) and new opportunities for gestational diabetes mellitus treatment. |
| format | Article |
| id | doaj-art-978741f742c541f2bcb9368718ac0bf5 |
| institution | OA Journals |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-978741f742c541f2bcb9368718ac0bf52025-08-20T01:57:08ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782016-05-0119216417010.14341/DM2004126-297373Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problemAnna I. Sazonova0Roza M. Esayan1Oksana I. Kolegaeva2Zhanna R. Gardanova3Research Center for Obstetrics, Gynecology and Perinatology, MoscowResearch Center for Obstetrics, Gynecology and Perinatology, MoscowResearch Center for Obstetrics, Gynecology and Perinatology, MoscowResearch Center for Obstetrics, Gynecology and Perinatology, MoscowHistorically, the following two methods were used to treat gestational diabetes mellitus: non-medical life-style interventions (diet and increased physical activity) and insulin treatment when other interventions were not effective. The possibility of alternative types of treatment such as oral anti-diabetic drugs has been the source of debate in recent years. Metformin is an oral anti-diabetic drug that reduces insulin resistance, which is common during gestation and is considered one of the main pathways of glucose metabolism alteration during pregnancy. The main concern is that metformin can cross the placenta and is found unchanged in foetal blood. This is the reason why oral anti-diabetic drugs are contraindicated during pregnancy in many countries, including Russia (according to the 2012 Russian recommendations for gestational diabetes treatment). In recent years, many studies investigating the safety and efficacy of metformin for maternal and foetal health have been published. We will review recent randomized clinical trials and discuss new international clinical recommendations (FIGO, 2015) and new opportunities for gestational diabetes mellitus treatment.https://www.dia-endojournals.ru/jour/article/view/7797metformingestational diabetes mellituspregnancy |
| spellingShingle | Anna I. Sazonova Roza M. Esayan Oksana I. Kolegaeva Zhanna R. Gardanova Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem Сахарный диабет metformin gestational diabetes mellitus pregnancy |
| title | Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem |
| title_full | Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem |
| title_fullStr | Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem |
| title_full_unstemmed | Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem |
| title_short | Efficacy and safety of metformin for the treatment of gestational diabetes: a new approach to the problem |
| title_sort | efficacy and safety of metformin for the treatment of gestational diabetes a new approach to the problem |
| topic | metformin gestational diabetes mellitus pregnancy |
| url | https://www.dia-endojournals.ru/jour/article/view/7797 |
| work_keys_str_mv | AT annaisazonova efficacyandsafetyofmetforminforthetreatmentofgestationaldiabetesanewapproachtotheproblem AT rozamesayan efficacyandsafetyofmetforminforthetreatmentofgestationaldiabetesanewapproachtotheproblem AT oksanaikolegaeva efficacyandsafetyofmetforminforthetreatmentofgestationaldiabetesanewapproachtotheproblem AT zhannargardanova efficacyandsafetyofmetforminforthetreatmentofgestationaldiabetesanewapproachtotheproblem |