Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications
Glucocorticoid administration before cardiopulmonary bypass (CPB) can reduce the systemic inflammatory response and improve clinical outcome. Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation. Twenty-nine children underg...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/730828 |
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| author | Franco Lerzo Giuseppe Peri Andrea Doni Paola Bocca Fabio Morandi Angela Pistorio Anna Maria Carleo Alberto Mantovani Vito Pistoia Ignazia Prigione |
| author_facet | Franco Lerzo Giuseppe Peri Andrea Doni Paola Bocca Fabio Morandi Angela Pistorio Anna Maria Carleo Alberto Mantovani Vito Pistoia Ignazia Prigione |
| author_sort | Franco Lerzo |
| collection | DOAJ |
| description | Glucocorticoid administration before cardiopulmonary bypass (CPB) can reduce the systemic inflammatory response and improve clinical outcome. Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation. Twenty-nine children undergoing open heart surgery were enrolled in the study. Fourteen received dexamethasone (1st dose 1.5 mg/Kg i.v. or i.m. the evening before surgery; 2nd dose 1.5 mg/kg i.v. before starting bypass) and fifteen children served as control. Blood PTX3, short pentraxin C-reactive protein (CRP), interleukin-1 receptor II (IL-1RII), fibrinogen and partial thromboplastin time (PTT) were assayed at different times. PTX3 levels significantly increased during CPB in dexamethasone-treated (+D) and dexamethasone-untreated (−D) subjects, but were significantly higher in +D than −D patients. CRP levels significantly increased both in +D and −D patients in the postoperative days, with values significantly higher in −D than +D patients. Fibrinogen and PTT values were significantly higher in −D than +D patients in the 1st postoperative day. IL-1RII plasma levels increased in the postoperative period in both groups. Dexamethasone prophylaxis in pediatric patients undergoing CPB for cardiac surgery is associated with a significant increase of blood PTX3 that could contribute to decreasing inflammatory parameters and improving patient clinical outcome. |
| format | Article |
| id | doaj-art-977fc86c2964461eb4c56acd893d782e |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
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| series | Clinical and Developmental Immunology |
| spelling | doaj-art-977fc86c2964461eb4c56acd893d782e2025-02-03T01:28:07ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/730828730828Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical ImplicationsFranco Lerzo0Giuseppe Peri1Andrea Doni2Paola Bocca3Fabio Morandi4Angela Pistorio5Anna Maria Carleo6Alberto Mantovani7Vito Pistoia8Ignazia Prigione9Division of Cardiovascular Surgery, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, ItalyDepartment of Immunology and Inflammation, Istituto Clinico Humanitas, IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, ItalyDepartment of Immunology and Inflammation, Istituto Clinico Humanitas, IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, ItalyLaboratory of Oncology, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, ItalyLaboratory of Oncology, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, ItalyClinical Epidemiology and Biostatistics Unit, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, ItalyDivision of Cardiovascular Surgery, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, ItalyDepartment of Immunology and Inflammation, Istituto Clinico Humanitas, IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, ItalyLaboratory of Oncology, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, ItalyLaboratory of Oncology, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, ItalyGlucocorticoid administration before cardiopulmonary bypass (CPB) can reduce the systemic inflammatory response and improve clinical outcome. Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation. Twenty-nine children undergoing open heart surgery were enrolled in the study. Fourteen received dexamethasone (1st dose 1.5 mg/Kg i.v. or i.m. the evening before surgery; 2nd dose 1.5 mg/kg i.v. before starting bypass) and fifteen children served as control. Blood PTX3, short pentraxin C-reactive protein (CRP), interleukin-1 receptor II (IL-1RII), fibrinogen and partial thromboplastin time (PTT) were assayed at different times. PTX3 levels significantly increased during CPB in dexamethasone-treated (+D) and dexamethasone-untreated (−D) subjects, but were significantly higher in +D than −D patients. CRP levels significantly increased both in +D and −D patients in the postoperative days, with values significantly higher in −D than +D patients. Fibrinogen and PTT values were significantly higher in −D than +D patients in the 1st postoperative day. IL-1RII plasma levels increased in the postoperative period in both groups. Dexamethasone prophylaxis in pediatric patients undergoing CPB for cardiac surgery is associated with a significant increase of blood PTX3 that could contribute to decreasing inflammatory parameters and improving patient clinical outcome.http://dx.doi.org/10.1155/2011/730828 |
| spellingShingle | Franco Lerzo Giuseppe Peri Andrea Doni Paola Bocca Fabio Morandi Angela Pistorio Anna Maria Carleo Alberto Mantovani Vito Pistoia Ignazia Prigione Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications Clinical and Developmental Immunology |
| title | Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications |
| title_full | Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications |
| title_fullStr | Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications |
| title_full_unstemmed | Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications |
| title_short | Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications |
| title_sort | dexamethasone prophylaxis in pediatric open heart surgery is associated with increased blood long pentraxin ptx3 potential clinical implications |
| url | http://dx.doi.org/10.1155/2011/730828 |
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