Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell Detection
Efforts have been made to enhance the surface sensitivity of the conventional surface plasmon resonance biosensor. To improve the sensitivity, a unique two-dimensional heterostructure layer of titanium disilicide and black phosphorus layer has been deposited over the metal surface. The titanium disi...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Optics |
| Online Access: | http://dx.doi.org/10.1155/2022/1476254 |
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| author | Bhishma Karki Arun Uniyal Amrindra Pal Vivek Srivastava |
| author_facet | Bhishma Karki Arun Uniyal Amrindra Pal Vivek Srivastava |
| author_sort | Bhishma Karki |
| collection | DOAJ |
| description | Efforts have been made to enhance the surface sensitivity of the conventional surface plasmon resonance biosensor. To improve the sensitivity, a unique two-dimensional heterostructure layer of titanium disilicide and black phosphorus layer has been deposited over the metal surface. The titanium disilicide (TiSi2) nanosheet is placed in between silver (Ag) and black phosphorus (BP) films in the Kretschmann arrangement. This biosensor executes better over a wide range of refractive index variations, including biological cell distribution in individual blood. It may become a fast method of detecting cancerous cells and the several variants of corona and other viruses that become pandemic. Using the finite element method-based simulation technique, the sensitivity obtained as 195.4 degree/RIU, 167.6 degree/RIU, 212.4 degree/RIU, 168.4 degree/RIU, 212.4 degree/RIU, 186.6 degree/RIU, 218.6 degree/RIU, 195.4 degree/RIU, 203.6 degree/RIU, 202.6 degree/RIU 203.6 degree/RIU, and 202.6 for basal (skin cancer), basal (normal cell), HeLa (cervical cancer), MCF-7 (breast cancer), HeLa (normal cell), Jurkat (blood cancer), Jurkat (normal cell), PCI-2 (adrenal gland cancer), PCI-2 (normal cell), MDA-MB-231 (breast cancer), MDA-MB-231 (normal cell), MCF-7 (breast cancer), and MCF-7 (normal cell), respectively, and other performance parameters such as detection accuracy, figure of merit, and full width and half maximum (FWHM) are also evaluated. |
| format | Article |
| id | doaj-art-977bee95fe2a4935ba74d7880201ef17 |
| institution | Kabale University |
| issn | 1687-9392 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Optics |
| spelling | doaj-art-977bee95fe2a4935ba74d7880201ef172025-02-03T01:22:59ZengWileyInternational Journal of Optics1687-93922022-01-01202210.1155/2022/1476254Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell DetectionBhishma Karki0Arun Uniyal1Amrindra Pal2Vivek Srivastava3Department of PhysicsDepartment of ECEDepartment of ECEDepartment of Mechanical EngineeringEfforts have been made to enhance the surface sensitivity of the conventional surface plasmon resonance biosensor. To improve the sensitivity, a unique two-dimensional heterostructure layer of titanium disilicide and black phosphorus layer has been deposited over the metal surface. The titanium disilicide (TiSi2) nanosheet is placed in between silver (Ag) and black phosphorus (BP) films in the Kretschmann arrangement. This biosensor executes better over a wide range of refractive index variations, including biological cell distribution in individual blood. It may become a fast method of detecting cancerous cells and the several variants of corona and other viruses that become pandemic. Using the finite element method-based simulation technique, the sensitivity obtained as 195.4 degree/RIU, 167.6 degree/RIU, 212.4 degree/RIU, 168.4 degree/RIU, 212.4 degree/RIU, 186.6 degree/RIU, 218.6 degree/RIU, 195.4 degree/RIU, 203.6 degree/RIU, 202.6 degree/RIU 203.6 degree/RIU, and 202.6 for basal (skin cancer), basal (normal cell), HeLa (cervical cancer), MCF-7 (breast cancer), HeLa (normal cell), Jurkat (blood cancer), Jurkat (normal cell), PCI-2 (adrenal gland cancer), PCI-2 (normal cell), MDA-MB-231 (breast cancer), MDA-MB-231 (normal cell), MCF-7 (breast cancer), and MCF-7 (normal cell), respectively, and other performance parameters such as detection accuracy, figure of merit, and full width and half maximum (FWHM) are also evaluated.http://dx.doi.org/10.1155/2022/1476254 |
| spellingShingle | Bhishma Karki Arun Uniyal Amrindra Pal Vivek Srivastava Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell Detection International Journal of Optics |
| title | Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell Detection |
| title_full | Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell Detection |
| title_fullStr | Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell Detection |
| title_full_unstemmed | Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell Detection |
| title_short | Advances in Surface Plasmon Resonance-Based Biosensor Technologies for Cancer Cell Detection |
| title_sort | advances in surface plasmon resonance based biosensor technologies for cancer cell detection |
| url | http://dx.doi.org/10.1155/2022/1476254 |
| work_keys_str_mv | AT bhishmakarki advancesinsurfaceplasmonresonancebasedbiosensortechnologiesforcancercelldetection AT arununiyal advancesinsurfaceplasmonresonancebasedbiosensortechnologiesforcancercelldetection AT amrindrapal advancesinsurfaceplasmonresonancebasedbiosensortechnologiesforcancercelldetection AT viveksrivastava advancesinsurfaceplasmonresonancebasedbiosensortechnologiesforcancercelldetection |