1,25-dihydroxyvitamin D3 improves non-alcoholic steatohepatitis phenotype in a diet-induced rat model

1,25-dihydroxyvitamin D3 improves non-alcoholic steatohepatitis phenotype in a diet-induced rat model

We studied the potential protective effects of 1,25-dihydroxyvitamin D3 (1,25 VD3) supplementation on liver damage induced by a choline-deficient (CD) diet in rats, where impaired liver function leads to decreased 25-hydroxyvitamin D3 levels, the precursor for the active 1,25 VD3. The CD diet reduce...

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Bibliographic Details
Main Authors: Mei Liu, Xiang-Zhun Song, Liu Yang, Yu-Hui Fang, Liu Lan, Jing-Shu Cui, Xiao-Chen Lu, Hai-Yang Zhu, Lin-Hu Quan, Hong-Mei Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Endocrinology
Subjects:
vitamin D3
non-alcoholic steatohepatitis
CYP450
inflammation
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2025.1528768/full
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