Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis
Retinoic acid-induced osteoporosis (RBM) is one of the most common causes of secondary osteoporosis. This study tested the anti-osteoporetic effect of quercetin in RBM-induced bone loss model (RBM). After 14-day supplementation of 13cRA to induce RBM, rats were administered with quercetin (100 mg/kg...
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2018-06-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://www.degruyter.com/view/j/pjfns.2018.68.issue-2/pjfns-2017-0023/pjfns-2017-0023.xml?format=INT |
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| author | Oršolić Nada Jeleč Željko Nemrava Johann Balta Vedran Gregorović Gordana Jeleč Dražen |
| author_facet | Oršolić Nada Jeleč Željko Nemrava Johann Balta Vedran Gregorović Gordana Jeleč Dražen |
| author_sort | Oršolić Nada |
| collection | DOAJ |
| description | Retinoic acid-induced osteoporosis (RBM) is one of the most common causes of secondary osteoporosis. This study tested the anti-osteoporetic effect of quercetin in RBM-induced bone loss model (RBM). After 14-day supplementation of 13cRA to induce RBM, rats were administered with quercetin (100 mg/kg) or alendronate (40 mg/kg). We analysed changes in body and uterine weight of animals, femoral geometric characteristics, calcium and phosphorus content, bone weight index, bone hystology, bone mineral density (BMD), markers of bone turnover, lipid peroxidation, glutathione levels and SOD, CAT activity of liver, kidney spleen, and ovary as well as biochemical and haematological variables. In comparison to the control RBM rats, the treatment with quercetin increased bone weight index, BMD, osteocalcin level, femoral geometric characteristics, calcium and phosphorus content in the 13cRA-induced bone loss model. Histological results showed its protective action through promotion of bone formation. According to the results, quercetin could be an effective substitution for alendronate in 13cRA-induced osteoporosis. Good therapeutic potential of quercetin on rat skeletal system is based partly on its antioxidant capacity and estrogenic activity. |
| format | Article |
| id | doaj-art-975d86933321423089ca20652307bd1a |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-975d86933321423089ca20652307bd1a2025-02-02T20:51:29ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072018-06-0168214916210.1515/pjfns-2017-0023pjfns-2017-0023Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced OsteoporosisOršolić Nada0Jeleč Željko1Nemrava Johann2Balta Vedran3Gregorović Gordana4Jeleč Dražen5Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, CroatiaDepartment of Orthopaedic Surgery, Specialty Hospital St. Catherine, Zabok, CroatiaDepartment of Surgery and Emergency medicine, General Hospital Zabok, CroatiaDepartment of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10000 Zagreb, CroatiaDivision of Biology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, HR-10000 Zagreb, CroatiaRoche d.o.o., Zagreb, CroatiaRetinoic acid-induced osteoporosis (RBM) is one of the most common causes of secondary osteoporosis. This study tested the anti-osteoporetic effect of quercetin in RBM-induced bone loss model (RBM). After 14-day supplementation of 13cRA to induce RBM, rats were administered with quercetin (100 mg/kg) or alendronate (40 mg/kg). We analysed changes in body and uterine weight of animals, femoral geometric characteristics, calcium and phosphorus content, bone weight index, bone hystology, bone mineral density (BMD), markers of bone turnover, lipid peroxidation, glutathione levels and SOD, CAT activity of liver, kidney spleen, and ovary as well as biochemical and haematological variables. In comparison to the control RBM rats, the treatment with quercetin increased bone weight index, BMD, osteocalcin level, femoral geometric characteristics, calcium and phosphorus content in the 13cRA-induced bone loss model. Histological results showed its protective action through promotion of bone formation. According to the results, quercetin could be an effective substitution for alendronate in 13cRA-induced osteoporosis. Good therapeutic potential of quercetin on rat skeletal system is based partly on its antioxidant capacity and estrogenic activity.http://www.degruyter.com/view/j/pjfns.2018.68.issue-2/pjfns-2017-0023/pjfns-2017-0023.xml?format=INTsecondary osteoporosisbone remodeling markersbone mineral densityquercetinhistologyrat |
| spellingShingle | Oršolić Nada Jeleč Željko Nemrava Johann Balta Vedran Gregorović Gordana Jeleč Dražen Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis Polish Journal of Food and Nutrition Sciences secondary osteoporosis bone remodeling markers bone mineral density quercetin histology rat |
| title | Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis |
| title_full | Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis |
| title_fullStr | Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis |
| title_full_unstemmed | Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis |
| title_short | Effect of Quercetin on Bone Mineral Status and Markers of Bone Turnover in Retinoic Acid-Induced Osteoporosis |
| title_sort | effect of quercetin on bone mineral status and markers of bone turnover in retinoic acid induced osteoporosis |
| topic | secondary osteoporosis bone remodeling markers bone mineral density quercetin histology rat |
| url | http://www.degruyter.com/view/j/pjfns.2018.68.issue-2/pjfns-2017-0023/pjfns-2017-0023.xml?format=INT |
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