Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis
IL-1β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and membrane-bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor-positive cells in an...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/948393 |
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| author | Alina A. Alshevskaya Julia A. Lopatnikova Nadezhda S. Shkaruba Oksana A. Chumasova Aleksey E. Sizikov Aleksander V. Karaulov Vladimir A. Kozlov Sergey V. Sennikov |
| author_facet | Alina A. Alshevskaya Julia A. Lopatnikova Nadezhda S. Shkaruba Oksana A. Chumasova Aleksey E. Sizikov Aleksander V. Karaulov Vladimir A. Kozlov Sergey V. Sennikov |
| author_sort | Alina A. Alshevskaya |
| collection | DOAJ |
| description | IL-1β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and membrane-bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor-positive cells in an immunocompetent subset but also on the density of receptor expression. The objective of this study was to investigate the expression of IL-1β membrane-bound receptors (IL-1R1 and IL-1R2) in terms of the percentage of receptor-positive cells and the number of receptors per cell in different subsets of immune cells in RA patients before and after a course of basic (excluding anticytokine) therapy and in healthy individuals. The resulting data indicate differences in the expression of IL-1β receptors among T cells, B cells, and monocytes in healthy volunteers and in rheumatoid arthritis patients. The importance of determining both the relative percentage of cells expressing receptors to immunomodulatory cytokines and the number of membrane-bound receptors per cell is highlighted by evidence of unidirectional or multidirectional changing of these parameters according to cell subset and health status. |
| format | Article |
| id | doaj-art-97592d6b7ff146f1b5b12c298c85295c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-97592d6b7ff146f1b5b12c298c85295c2025-02-03T01:00:54ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/948393948393Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid ArthritisAlina A. Alshevskaya0Julia A. Lopatnikova1Nadezhda S. Shkaruba2Oksana A. Chumasova3Aleksey E. Sizikov4Aleksander V. Karaulov5Vladimir A. Kozlov6Sergey V. Sennikov7Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Yadrintsevskaya Street 14, Novosibirsk 630099, RussiaFederal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Yadrintsevskaya Street 14, Novosibirsk 630099, RussiaFederal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Yadrintsevskaya Street 14, Novosibirsk 630099, RussiaFederal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Yadrintsevskaya Street 14, Novosibirsk 630099, RussiaFederal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Yadrintsevskaya Street 14, Novosibirsk 630099, RussiaI.M. Sechenov First Moscow State Medical University of the Ministry of Health, Bolshaya Pirogovskaya Street 2-4, Moscow 119991, RussiaFederal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Yadrintsevskaya Street 14, Novosibirsk 630099, RussiaFederal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Yadrintsevskaya Street 14, Novosibirsk 630099, RussiaIL-1β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and membrane-bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor-positive cells in an immunocompetent subset but also on the density of receptor expression. The objective of this study was to investigate the expression of IL-1β membrane-bound receptors (IL-1R1 and IL-1R2) in terms of the percentage of receptor-positive cells and the number of receptors per cell in different subsets of immune cells in RA patients before and after a course of basic (excluding anticytokine) therapy and in healthy individuals. The resulting data indicate differences in the expression of IL-1β receptors among T cells, B cells, and monocytes in healthy volunteers and in rheumatoid arthritis patients. The importance of determining both the relative percentage of cells expressing receptors to immunomodulatory cytokines and the number of membrane-bound receptors per cell is highlighted by evidence of unidirectional or multidirectional changing of these parameters according to cell subset and health status.http://dx.doi.org/10.1155/2015/948393 |
| spellingShingle | Alina A. Alshevskaya Julia A. Lopatnikova Nadezhda S. Shkaruba Oksana A. Chumasova Aleksey E. Sizikov Aleksander V. Karaulov Vladimir A. Kozlov Sergey V. Sennikov Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis Mediators of Inflammation |
| title | Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis |
| title_full | Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis |
| title_fullStr | Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis |
| title_full_unstemmed | Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis |
| title_short | Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis |
| title_sort | differences of il 1β receptors expression by immunocompetent cells subsets in rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2015/948393 |
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