The role of 18F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis
Abstract Background and aim The present study aimed to evaluate the use of 18F-2-[18F]-fluoro-2-deoxy-d-glucose (FDG) PET/MRI (Positron emission tomography-computed tomography) in predicting the pathological response to neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC) compared to t...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Radiation Oncology |
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| Online Access: | https://doi.org/10.1186/s13014-024-02507-5 |
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| author | Milad Ghanikolahloo Hayder Jasim Taher Ayoob Dinar Abdullah Mahsa Asadi Anar Ali Tayebi Rahil Rahimi Faranak Olamaeian Nima Rahimikashkooli Nima Kargar |
| author_facet | Milad Ghanikolahloo Hayder Jasim Taher Ayoob Dinar Abdullah Mahsa Asadi Anar Ali Tayebi Rahil Rahimi Faranak Olamaeian Nima Rahimikashkooli Nima Kargar |
| author_sort | Milad Ghanikolahloo |
| collection | DOAJ |
| description | Abstract Background and aim The present study aimed to evaluate the use of 18F-2-[18F]-fluoro-2-deoxy-d-glucose (FDG) PET/MRI (Positron emission tomography-computed tomography) in predicting the pathological response to neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC) compared to the use of MRI (Magnetic Resonance Imaging) alone. Methods We searched numerous databases, including PubMed, Scopus, Embase, and Science Direct, using curated keywords. The variance of each study was determined using the binomial distribution, and STATA version 14 was used to analyze the data by performing random-effect models. Additionally, we calculated study heterogeneity using the chi-squared test and I2 index and utilized funnel plots and Egger tests to assess publication bias. Results The current investigation analyzed 239 patients from six published studies. The pooled estimated sensitivity and specificity of 18F-FDG PET/MRI was 0.91 (95% CI = 0.90 to 0.92, I2 = 100% and P = 0.000) and 0.62 (95% CI = 0.53 to 0.72, I2 = 99.8% and P = 0.000), respectively. Pooled sensitivity and specificity of MRI were 0.78 (95%CI = 0.59 to 0.96, I2 = 100% and P = 0.000) and 0.56 (95%CI = 0.33 to 0.80, I2 = 99.8% and P = 0.000), respectively. Conclusions Based on our findings, the combined form of 18F-FDG PET/MRI imaging is more sensitive and specific than MRI alone for predicting response to NAC in BC patients. |
| format | Article |
| id | doaj-art-974e011122214f38a2e0e4d65c74ef99 |
| institution | OA Journals |
| issn | 1748-717X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj-art-974e011122214f38a2e0e4d65c74ef992025-08-20T02:22:24ZengBMCRadiation Oncology1748-717X2024-11-0119111010.1186/s13014-024-02507-5The role of 18F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysisMilad Ghanikolahloo0Hayder Jasim Taher1Ayoob Dinar Abdullah2Mahsa Asadi Anar3Ali Tayebi4Rahil Rahimi5Faranak Olamaeian6Nima Rahimikashkooli7Nima Kargar8King’s College HospitalDepartment of Radiology, Hilla University CollegeRadiology Technology Department, Al-Manara College for Medical SciencesStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical SciencesFiroozabadi Clinical Research Development Unit (FACRDU), School of Medicine, Iran University of Medical Sciences (IUMS)Department of Radiology, Advanced Diagnostic and Interventional Radiology Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences (IUMS)Firoozabadi Clinical Research Development Unit (FACRDU), School of Medicine, Iran University of Medical Sciences (IUMS)Internal Medicine Department, School of Medicine, Shiraz University of Medical SciencesInternal Medicine Department, School of Medicine, Shiraz University of Medical SciencesAbstract Background and aim The present study aimed to evaluate the use of 18F-2-[18F]-fluoro-2-deoxy-d-glucose (FDG) PET/MRI (Positron emission tomography-computed tomography) in predicting the pathological response to neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC) compared to the use of MRI (Magnetic Resonance Imaging) alone. Methods We searched numerous databases, including PubMed, Scopus, Embase, and Science Direct, using curated keywords. The variance of each study was determined using the binomial distribution, and STATA version 14 was used to analyze the data by performing random-effect models. Additionally, we calculated study heterogeneity using the chi-squared test and I2 index and utilized funnel plots and Egger tests to assess publication bias. Results The current investigation analyzed 239 patients from six published studies. The pooled estimated sensitivity and specificity of 18F-FDG PET/MRI was 0.91 (95% CI = 0.90 to 0.92, I2 = 100% and P = 0.000) and 0.62 (95% CI = 0.53 to 0.72, I2 = 99.8% and P = 0.000), respectively. Pooled sensitivity and specificity of MRI were 0.78 (95%CI = 0.59 to 0.96, I2 = 100% and P = 0.000) and 0.56 (95%CI = 0.33 to 0.80, I2 = 99.8% and P = 0.000), respectively. Conclusions Based on our findings, the combined form of 18F-FDG PET/MRI imaging is more sensitive and specific than MRI alone for predicting response to NAC in BC patients.https://doi.org/10.1186/s13014-024-02507-5Neoadjuvant chemotherapy18F-FDG PET/MRIPathological complete responseBreast cancer |
| spellingShingle | Milad Ghanikolahloo Hayder Jasim Taher Ayoob Dinar Abdullah Mahsa Asadi Anar Ali Tayebi Rahil Rahimi Faranak Olamaeian Nima Rahimikashkooli Nima Kargar The role of 18F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis Radiation Oncology Neoadjuvant chemotherapy 18F-FDG PET/MRI Pathological complete response Breast cancer |
| title | The role of 18F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis |
| title_full | The role of 18F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis |
| title_fullStr | The role of 18F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis |
| title_full_unstemmed | The role of 18F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis |
| title_short | The role of 18F-FDG PET/MRI in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: a systematic review and meta-analysis |
| title_sort | role of 18f fdg pet mri in assessing pathological complete response to neoadjuvant chemotherapy in patients with breast cancer a systematic review and meta analysis |
| topic | Neoadjuvant chemotherapy 18F-FDG PET/MRI Pathological complete response Breast cancer |
| url | https://doi.org/10.1186/s13014-024-02507-5 |
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