Mutational Analysis of Substrate Recognition in Trypsin-like Protease Cocoonase: Protein Memory Induced by Alterations in Substrate-Binding Site

Mutational Analysis of Substrate Recognition in Trypsin-like Protease Cocoonase: Protein Memory Induced by Alterations in Substrate-Binding Site

To investigate the substrate recognition mechanism of trypsin-like protease cocoonase (CCN), mutational analyses were conducted at key substrate recognition sites, Asp187 and Ser188, and their effects on substrate specificity and enzymatic activity were evaluated. Mutants with the Asp187 substitutio...

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Bibliographic Details
Main Authors: Nana Sakata, Shigeru Shimamoto, Yuri Murakami, Orika Ashida, Toshiki Takei, Mitsuhiro Miyazawa, Yuji Hidaka
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
chaperone
chymotrypsin
cocoonase
folding
substrate binding
Online Access:https://www.mdpi.com/1420-3049/29/22/5476
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