Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease
Objectives. We determined the serum bile acid (BA) composition in patients with liver diseases and healthy volunteers to investigate the relationship between the etiologies of liver disease and BA metabolism. Material and Methods. Sera from 150 patients with liver diseases and 46 healthy volunteers...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/717431 |
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| author | Tomonori Sugita Katsushi Amano Masanori Nakano Noriko Masubuchi Masahiro Sugihara Tomokazu Matsuura |
| author_facet | Tomonori Sugita Katsushi Amano Masanori Nakano Noriko Masubuchi Masahiro Sugihara Tomokazu Matsuura |
| author_sort | Tomonori Sugita |
| collection | DOAJ |
| description | Objectives. We determined the serum bile acid (BA) composition in patients with liver diseases and healthy volunteers to investigate the relationship between the etiologies of liver disease and BA metabolism. Material and Methods. Sera from 150 patients with liver diseases and 46 healthy volunteers were obtained. The serum concentrations of the 16 different BAs were determined according to the LC-MS/MS method and were compared between the different liver diseases. Results. A total of 150 subjects, including patients with hepatitis C virus (HCV) (n=44), hepatitis B virus (HBV) (n=23), alcoholic liver disease (ALD) (n=21), biliary tract disease (n=20), nonalcoholic fatty liver disease (NAFLD) (n=13), and other liver diseases (n=29), were recruited. The levels of UDCA and GUDCA were significantly higher in the ALD group, and the levels of DCA and UDCA were significantly lower in the biliary tract diseases group than in viral hepatitis group. In the UDCA therapy (−) subgroup, a significantly lower level of TLCA was observed in the ALD group, with lower levels of CDCA, DCA, and GLCA noted in biliary tract diseases group compared to viral hepatitis group. Conclusions. Analysis of the BA composition may be useful for differential diagnosis in liver disease. |
| format | Article |
| id | doaj-art-97256ef983154b01800b45602e231bc3 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-97256ef983154b01800b45602e231bc32025-02-03T01:01:13ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/717431717431Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver DiseaseTomonori Sugita0Katsushi Amano1Masanori Nakano2Noriko Masubuchi3Masahiro Sugihara4Tomokazu Matsuura5Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato, Tokyo 105-8461, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato, Tokyo 105-8461, JapanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato, Tokyo 105-8461, JapanDrug Metabolism & Pharmacokinetics Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., Tokyo, JapanClinical Data & Biostatistics Department, R&D Division, Daiichi Sankyo Co., Ltd., Tokyo, JapanDepartment of Laboratory Medicine, The Jikei University School of Medicine, Tokyo, JapanObjectives. We determined the serum bile acid (BA) composition in patients with liver diseases and healthy volunteers to investigate the relationship between the etiologies of liver disease and BA metabolism. Material and Methods. Sera from 150 patients with liver diseases and 46 healthy volunteers were obtained. The serum concentrations of the 16 different BAs were determined according to the LC-MS/MS method and were compared between the different liver diseases. Results. A total of 150 subjects, including patients with hepatitis C virus (HCV) (n=44), hepatitis B virus (HBV) (n=23), alcoholic liver disease (ALD) (n=21), biliary tract disease (n=20), nonalcoholic fatty liver disease (NAFLD) (n=13), and other liver diseases (n=29), were recruited. The levels of UDCA and GUDCA were significantly higher in the ALD group, and the levels of DCA and UDCA were significantly lower in the biliary tract diseases group than in viral hepatitis group. In the UDCA therapy (−) subgroup, a significantly lower level of TLCA was observed in the ALD group, with lower levels of CDCA, DCA, and GLCA noted in biliary tract diseases group compared to viral hepatitis group. Conclusions. Analysis of the BA composition may be useful for differential diagnosis in liver disease.http://dx.doi.org/10.1155/2015/717431 |
| spellingShingle | Tomonori Sugita Katsushi Amano Masanori Nakano Noriko Masubuchi Masahiro Sugihara Tomokazu Matsuura Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease Gastroenterology Research and Practice |
| title | Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease |
| title_full | Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease |
| title_fullStr | Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease |
| title_full_unstemmed | Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease |
| title_short | Analysis of the Serum Bile Acid Composition for Differential Diagnosis in Patients with Liver Disease |
| title_sort | analysis of the serum bile acid composition for differential diagnosis in patients with liver disease |
| url | http://dx.doi.org/10.1155/2015/717431 |
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