Recent advances in genetics of aggressive behavior
One of the most important problems of modern neurobiology and medicine is an understanding of the mechanisms of normal and pathological behavior of a person. Aggressive behavior is an integral part of the human psyche. However, environmental risk factors, mental illness and somatic diseases can lead...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2018-09-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/1658 |
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| author | J. D. Davydova S. S. Litvinov R. F. Enikeeva S. B. Malykh E. K. Khusnutdinova |
| author_facet | J. D. Davydova S. S. Litvinov R. F. Enikeeva S. B. Malykh E. K. Khusnutdinova |
| author_sort | J. D. Davydova |
| collection | DOAJ |
| description | One of the most important problems of modern neurobiology and medicine is an understanding of the mechanisms of normal and pathological behavior of a person. Aggressive behavior is an integral part of the human psyche. However, environmental risk factors, mental illness and somatic diseases can lead to increased aggression to be the biological basis of antisocial behavior in a human society. An important role in development of aggressive behavior belongs to the hereditary factors that may be linked to abnormal functioning of neurotransmitter systems in the brain yet the underlying genetic mechanisms remain unclear, which is due to a large number of single nucleotide polymorphisms, insertions and deletions in the structure of genes that encode the components of the neurotransmitter systems. The most studied candidate genes for aggressive behavior are serotonergic (TPH1, TPH2, HTR2A, SLC6A4) and dopaminergic (DRD4, SLC6A3) system genes, as well as the serotonin or catecholamine metabolizing enzyme genes (COMT, MAOA). In addition, there is evidence that the hypothalamic-pituitary system genes (OXT, OXTR, AVPR1A, AVPR1B), the sex hormone receptors genes (ER1, AR), neurotrophin (BDNF) and neuronal apoptosis genes (CASP3, BAX) may also be involved in development of aggressive behavior. The results of Genome-Wide Association Studies (GWAS) have demonstrated that FYN, LRRTM4, NTM, CDH13, DYRK1A and other genes are involved in regulation of aggressive behavior. These and other evidence suggest that genetic predisposition to aggressive behavior may be a very complex process. |
| format | Article |
| id | doaj-art-971bde96234b41169e7f3a855dcd822d |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-971bde96234b41169e7f3a855dcd822d2025-02-01T09:58:06ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592018-09-0122671672510.18699/VJ18.415814Recent advances in genetics of aggressive behaviorJ. D. Davydova0S. S. Litvinov1R. F. Enikeeva2S. B. Malykh3E. K. Khusnutdinova4Institute of Biochemistry and Genetics, Ufa Federal Research Centre of RAS.Institute of Biochemistry and Genetics, Ufa Federal Research Centre of RAS.Institute of Biochemistry and Genetics, Ufa Federal Research Centre of RAS.Psychological Institute, Russian Academy of Education.Institute of Biochemistry and Genetics, Ufa Federal Research Centre of RAS; Department of Genetics and Fundamental Medicine, Bashkir State University.One of the most important problems of modern neurobiology and medicine is an understanding of the mechanisms of normal and pathological behavior of a person. Aggressive behavior is an integral part of the human psyche. However, environmental risk factors, mental illness and somatic diseases can lead to increased aggression to be the biological basis of antisocial behavior in a human society. An important role in development of aggressive behavior belongs to the hereditary factors that may be linked to abnormal functioning of neurotransmitter systems in the brain yet the underlying genetic mechanisms remain unclear, which is due to a large number of single nucleotide polymorphisms, insertions and deletions in the structure of genes that encode the components of the neurotransmitter systems. The most studied candidate genes for aggressive behavior are serotonergic (TPH1, TPH2, HTR2A, SLC6A4) and dopaminergic (DRD4, SLC6A3) system genes, as well as the serotonin or catecholamine metabolizing enzyme genes (COMT, MAOA). In addition, there is evidence that the hypothalamic-pituitary system genes (OXT, OXTR, AVPR1A, AVPR1B), the sex hormone receptors genes (ER1, AR), neurotrophin (BDNF) and neuronal apoptosis genes (CASP3, BAX) may also be involved in development of aggressive behavior. The results of Genome-Wide Association Studies (GWAS) have demonstrated that FYN, LRRTM4, NTM, CDH13, DYRK1A and other genes are involved in regulation of aggressive behavior. These and other evidence suggest that genetic predisposition to aggressive behavior may be a very complex process.https://vavilov.elpub.ru/jour/article/view/1658aggressionaggressive behaviorbehavior geneticsneurotransmitter systemspolymorphisms |
| spellingShingle | J. D. Davydova S. S. Litvinov R. F. Enikeeva S. B. Malykh E. K. Khusnutdinova Recent advances in genetics of aggressive behavior Вавиловский журнал генетики и селекции aggression aggressive behavior behavior genetics neurotransmitter systems polymorphisms |
| title | Recent advances in genetics of aggressive behavior |
| title_full | Recent advances in genetics of aggressive behavior |
| title_fullStr | Recent advances in genetics of aggressive behavior |
| title_full_unstemmed | Recent advances in genetics of aggressive behavior |
| title_short | Recent advances in genetics of aggressive behavior |
| title_sort | recent advances in genetics of aggressive behavior |
| topic | aggression aggressive behavior behavior genetics neurotransmitter systems polymorphisms |
| url | https://vavilov.elpub.ru/jour/article/view/1658 |
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