Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors
This retrospective cohort study using SEER data from 2000 to 2020 examines the impact of radiotherapy on the risk of Secondary Primary Lung Cancer (SPLC) in 224,396 elderly female breast cancer survivors. Patients treated with radiotherapy displayed a 31 % increased SPLC risk compared to those not t...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523325000087 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591856618176512 |
|---|---|
| author | Jieming Lu Zhimin Shen Xiaoqing Wang Yanhong Lin Ziyang Han Mingqiang Kang |
| author_facet | Jieming Lu Zhimin Shen Xiaoqing Wang Yanhong Lin Ziyang Han Mingqiang Kang |
| author_sort | Jieming Lu |
| collection | DOAJ |
| description | This retrospective cohort study using SEER data from 2000 to 2020 examines the impact of radiotherapy on the risk of Secondary Primary Lung Cancer (SPLC) in 224,396 elderly female breast cancer survivors. Patients treated with radiotherapy displayed a 31 % increased SPLC risk compared to those not treated. Utilizing Cox Proportional Hazards and Poisson regression models, the study assessed various factors including age, race, and tumor characteristics. Propensity Score Matching (PSM) was employed to balance cohorts for survival analysis, which revealed that radiotherapy did not negatively impact overall survival despite the increased risk of SPLC. A nomogram was developed to aid clinical decision-making by predicting survival outcomes. The findings advocate for personalized treatment strategies and continuous monitoring to manage potential long-term adverse effects effectively, highlighting the need for a balanced approach in the treatment of breast cancer survivors. |
| format | Article |
| id | doaj-art-971ac24bf38c49debd705108cc561aef |
| institution | Kabale University |
| issn | 1936-5233 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj-art-971ac24bf38c49debd705108cc561aef2025-01-22T05:41:36ZengElsevierTranslational Oncology1936-52332025-02-0152102277Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivorsJieming Lu0Zhimin Shen1Xiaoqing Wang2Yanhong Lin3Ziyang Han4Mingqiang Kang5Department of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), China; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, China; Clinical Research Center for Thoracic Tumors of Fujian Province, ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), ChinaDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), China; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, China; Clinical Research Center for Thoracic Tumors of Fujian Province, China; Corresponding authors.Department of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), China; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, China; Clinical Research Center for Thoracic Tumors of Fujian Province, China; Corresponding authors.This retrospective cohort study using SEER data from 2000 to 2020 examines the impact of radiotherapy on the risk of Secondary Primary Lung Cancer (SPLC) in 224,396 elderly female breast cancer survivors. Patients treated with radiotherapy displayed a 31 % increased SPLC risk compared to those not treated. Utilizing Cox Proportional Hazards and Poisson regression models, the study assessed various factors including age, race, and tumor characteristics. Propensity Score Matching (PSM) was employed to balance cohorts for survival analysis, which revealed that radiotherapy did not negatively impact overall survival despite the increased risk of SPLC. A nomogram was developed to aid clinical decision-making by predicting survival outcomes. The findings advocate for personalized treatment strategies and continuous monitoring to manage potential long-term adverse effects effectively, highlighting the need for a balanced approach in the treatment of breast cancer survivors.http://www.sciencedirect.com/science/article/pii/S1936523325000087Secondary primary lung cancerBreast cancer survivorsRadiotherapyElderly WomenSurvival Analysis |
| spellingShingle | Jieming Lu Zhimin Shen Xiaoqing Wang Yanhong Lin Ziyang Han Mingqiang Kang Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors Translational Oncology Secondary primary lung cancer Breast cancer survivors Radiotherapy Elderly Women Survival Analysis |
| title | Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors |
| title_full | Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors |
| title_fullStr | Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors |
| title_full_unstemmed | Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors |
| title_short | Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors |
| title_sort | impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors |
| topic | Secondary primary lung cancer Breast cancer survivors Radiotherapy Elderly Women Survival Analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1936523325000087 |
| work_keys_str_mv | AT jieminglu impactofradiotherapyonsecondarylungcancerriskandsurvivalinelderlyfemalebreastcancersurvivors AT zhiminshen impactofradiotherapyonsecondarylungcancerriskandsurvivalinelderlyfemalebreastcancersurvivors AT xiaoqingwang impactofradiotherapyonsecondarylungcancerriskandsurvivalinelderlyfemalebreastcancersurvivors AT yanhonglin impactofradiotherapyonsecondarylungcancerriskandsurvivalinelderlyfemalebreastcancersurvivors AT ziyanghan impactofradiotherapyonsecondarylungcancerriskandsurvivalinelderlyfemalebreastcancersurvivors AT mingqiangkang impactofradiotherapyonsecondarylungcancerriskandsurvivalinelderlyfemalebreastcancersurvivors |