Dermatomyositis Associated with Myelofibrosis following Polycythemia Vera
Dermatomyositis (DM) is a unique inflammatory myopathy with clinical findings of proximal muscle weakness, characteristic rash, and elevated muscle enzymes. The association of DM and malignancy, most commonly adenocarcinoma, is well known. There have been few case reports of primary myelofibrosis as...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/9091612 |
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| _version_ | 1832565249480327168 |
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| author | Naomi Fei Sarah Sofka |
| author_facet | Naomi Fei Sarah Sofka |
| author_sort | Naomi Fei |
| collection | DOAJ |
| description | Dermatomyositis (DM) is a unique inflammatory myopathy with clinical findings of proximal muscle weakness, characteristic rash, and elevated muscle enzymes. The association of DM and malignancy, most commonly adenocarcinoma, is well known. There have been few case reports of primary myelofibrosis associated with DM. We present the case of a 69-year-old male with a history of polycythemia vera (PV) who developed proximal muscle weakness, dysphagia, and rash. He was found to have elevated creatinine kinase and skin biopsy was consistent with DM. Due to persistent pancytopenia a bone marrow biopsy was performed and showed postpolycythemic myelofibrosis. To our knowledge, this is the first case reported of this unique association. |
| format | Article |
| id | doaj-art-97136948af8045c6b357f781738bcb22 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-97136948af8045c6b357f781738bcb222025-02-03T01:08:57ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/90916129091612Dermatomyositis Associated with Myelofibrosis following Polycythemia VeraNaomi Fei0Sarah Sofka1Department of Internal Medicine, West Virginia University Hospital, 1 Medical Center Dr., Morgantown, WV 26505, USADepartment of Internal Medicine, West Virginia University Hospital, 1 Medical Center Dr., Morgantown, WV 26505, USADermatomyositis (DM) is a unique inflammatory myopathy with clinical findings of proximal muscle weakness, characteristic rash, and elevated muscle enzymes. The association of DM and malignancy, most commonly adenocarcinoma, is well known. There have been few case reports of primary myelofibrosis associated with DM. We present the case of a 69-year-old male with a history of polycythemia vera (PV) who developed proximal muscle weakness, dysphagia, and rash. He was found to have elevated creatinine kinase and skin biopsy was consistent with DM. Due to persistent pancytopenia a bone marrow biopsy was performed and showed postpolycythemic myelofibrosis. To our knowledge, this is the first case reported of this unique association.http://dx.doi.org/10.1155/2017/9091612 |
| spellingShingle | Naomi Fei Sarah Sofka Dermatomyositis Associated with Myelofibrosis following Polycythemia Vera Case Reports in Hematology |
| title | Dermatomyositis Associated with Myelofibrosis following Polycythemia Vera |
| title_full | Dermatomyositis Associated with Myelofibrosis following Polycythemia Vera |
| title_fullStr | Dermatomyositis Associated with Myelofibrosis following Polycythemia Vera |
| title_full_unstemmed | Dermatomyositis Associated with Myelofibrosis following Polycythemia Vera |
| title_short | Dermatomyositis Associated with Myelofibrosis following Polycythemia Vera |
| title_sort | dermatomyositis associated with myelofibrosis following polycythemia vera |
| url | http://dx.doi.org/10.1155/2017/9091612 |
| work_keys_str_mv | AT naomifei dermatomyositisassociatedwithmyelofibrosisfollowingpolycythemiavera AT sarahsofka dermatomyositisassociatedwithmyelofibrosisfollowingpolycythemiavera |