Nucleus pulposus cell network modelling in the intervertebral disc
Abstract Intervertebral disc degeneration (IDD) results from an imbalance between anabolic and catabolic processes in the extracellular matrix (ECM). Due to complex biochemical interactions, a comprehensive understanding is needed. This study presents a regulatory network model (RNM) for nucleus pul...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Systems Biology and Applications |
| Online Access: | https://doi.org/10.1038/s41540-024-00479-6 |
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| author | Sofia Tseranidou Maria Segarra-Queralt Francis Kiptengwer Chemorion Christine Lyn Le Maitre Janet Piñero Jérôme Noailly |
| author_facet | Sofia Tseranidou Maria Segarra-Queralt Francis Kiptengwer Chemorion Christine Lyn Le Maitre Janet Piñero Jérôme Noailly |
| author_sort | Sofia Tseranidou |
| collection | DOAJ |
| description | Abstract Intervertebral disc degeneration (IDD) results from an imbalance between anabolic and catabolic processes in the extracellular matrix (ECM). Due to complex biochemical interactions, a comprehensive understanding is needed. This study presents a regulatory network model (RNM) for nucleus pulposus cells (NPC), representing normal intervertebral disc (IVD) conditions. The RNM includes 33 proteins, and 153 interactions based on literature, incorporating key NPC regulatory mechanisms. A semi-quantitative approach calculates the basal steady state, accurately reflecting normal NPC activity. Model validation through published studies replicated pro-catabolic and pro-anabolic shifts, emphasizing the roles of transforming growth factor beta (TGF-β) and interleukin-1 receptor antagonist (IL-1Ra) in ECM regulation. This IVD RNM is a valuable tool for predicting IDD progression, offering insights into ECM degradation mechanisms and guiding experimental research on IVD health and degeneration. |
| format | Article |
| id | doaj-art-971363374bc049c5a74781ffed7cac69 |
| institution | Kabale University |
| issn | 2056-7189 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Systems Biology and Applications |
| spelling | doaj-art-971363374bc049c5a74781ffed7cac692025-02-02T12:30:23ZengNature Portfolionpj Systems Biology and Applications2056-71892025-01-0111111710.1038/s41540-024-00479-6Nucleus pulposus cell network modelling in the intervertebral discSofia Tseranidou0Maria Segarra-Queralt1Francis Kiptengwer Chemorion2Christine Lyn Le Maitre3Janet Piñero4Jérôme Noailly5Department of Engineering, Universitat Pompeu FabraDepartment of Engineering, Universitat Pompeu FabraDepartment of Engineering, Universitat Pompeu FabraDivision of Clinical Medicine, School of Medicine and Population Health, University of SheffieldHospital del Mar Medical Research InstituteDepartment of Engineering, Universitat Pompeu FabraAbstract Intervertebral disc degeneration (IDD) results from an imbalance between anabolic and catabolic processes in the extracellular matrix (ECM). Due to complex biochemical interactions, a comprehensive understanding is needed. This study presents a regulatory network model (RNM) for nucleus pulposus cells (NPC), representing normal intervertebral disc (IVD) conditions. The RNM includes 33 proteins, and 153 interactions based on literature, incorporating key NPC regulatory mechanisms. A semi-quantitative approach calculates the basal steady state, accurately reflecting normal NPC activity. Model validation through published studies replicated pro-catabolic and pro-anabolic shifts, emphasizing the roles of transforming growth factor beta (TGF-β) and interleukin-1 receptor antagonist (IL-1Ra) in ECM regulation. This IVD RNM is a valuable tool for predicting IDD progression, offering insights into ECM degradation mechanisms and guiding experimental research on IVD health and degeneration.https://doi.org/10.1038/s41540-024-00479-6 |
| spellingShingle | Sofia Tseranidou Maria Segarra-Queralt Francis Kiptengwer Chemorion Christine Lyn Le Maitre Janet Piñero Jérôme Noailly Nucleus pulposus cell network modelling in the intervertebral disc npj Systems Biology and Applications |
| title | Nucleus pulposus cell network modelling in the intervertebral disc |
| title_full | Nucleus pulposus cell network modelling in the intervertebral disc |
| title_fullStr | Nucleus pulposus cell network modelling in the intervertebral disc |
| title_full_unstemmed | Nucleus pulposus cell network modelling in the intervertebral disc |
| title_short | Nucleus pulposus cell network modelling in the intervertebral disc |
| title_sort | nucleus pulposus cell network modelling in the intervertebral disc |
| url | https://doi.org/10.1038/s41540-024-00479-6 |
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