Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective
Gut microbiota is crucial for protecting the homeostasis of immune locally and systemically, and its dysbiosis is essentially correlated to tumorigenesis, cancer progression, and refractoriness to cancer treatments, including the novel immunotherapy. Increasing evidence unravel the intricate role of...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2025-01-01
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| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0600 |
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| _version_ | 1832590760971599872 |
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| author | Yuhui Tang Qiaoting Cai Zhi Tian Wenkuan Chen Hailin Tang |
| author_facet | Yuhui Tang Qiaoting Cai Zhi Tian Wenkuan Chen Hailin Tang |
| author_sort | Yuhui Tang |
| collection | DOAJ |
| description | Gut microbiota is crucial for protecting the homeostasis of immune locally and systemically, and its dysbiosis is essentially correlated to tumorigenesis, cancer progression, and refractoriness to cancer treatments, including the novel immunotherapy. Increasing evidence unravel the intricate role of gut microbiota in reshaping tumor microenvironment and affecting the efficacy and toxicities of immunotherapy, which shed more light on the future applications of gut microbiota in efficacious biomarker and combination treatment of immunotherapy. To better grasp the underlying crosstalk between gut microbiota and immunotherapy, more experimental and clinical trials are indispensable for the customized gut microbiota-based treatments in cancer patients undergoing immunotherapy. |
| format | Article |
| id | doaj-art-9709a321905243a69d3b94c708ee6a73 |
| institution | Kabale University |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-9709a321905243a69d3b94c708ee6a732025-01-23T08:00:58ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0600Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future PerspectiveYuhui Tang0Qiaoting Cai1Zhi Tian2Wenkuan Chen3Hailin Tang4State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA.State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.Gut microbiota is crucial for protecting the homeostasis of immune locally and systemically, and its dysbiosis is essentially correlated to tumorigenesis, cancer progression, and refractoriness to cancer treatments, including the novel immunotherapy. Increasing evidence unravel the intricate role of gut microbiota in reshaping tumor microenvironment and affecting the efficacy and toxicities of immunotherapy, which shed more light on the future applications of gut microbiota in efficacious biomarker and combination treatment of immunotherapy. To better grasp the underlying crosstalk between gut microbiota and immunotherapy, more experimental and clinical trials are indispensable for the customized gut microbiota-based treatments in cancer patients undergoing immunotherapy.https://spj.science.org/doi/10.34133/research.0600 |
| spellingShingle | Yuhui Tang Qiaoting Cai Zhi Tian Wenkuan Chen Hailin Tang Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective Research |
| title | Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective |
| title_full | Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective |
| title_fullStr | Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective |
| title_full_unstemmed | Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective |
| title_short | Crosstalk between Gut Microbiota and Cancer Immunotherapy: Present Investigations and Future Perspective |
| title_sort | crosstalk between gut microbiota and cancer immunotherapy present investigations and future perspective |
| url | https://spj.science.org/doi/10.34133/research.0600 |
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