Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant Evaluation
Coronary artery disease (CAD) is prevalent in patients with end-stage liver disease and associated with poor outcomes when undergoing orthotopic liver transplantation (OLT); however, noninvasive screening for CAD in this population is less sensitive. In an attempt to identify redundancy, we reviewed...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2016/7187206 |
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| author | Bryan C. Lee Feng Li Adam J. Hanje Khalid Mumtaz Konstantinos D. Boudoulas Scott M. Lilly |
| author_facet | Bryan C. Lee Feng Li Adam J. Hanje Khalid Mumtaz Konstantinos D. Boudoulas Scott M. Lilly |
| author_sort | Bryan C. Lee |
| collection | DOAJ |
| description | Coronary artery disease (CAD) is prevalent in patients with end-stage liver disease and associated with poor outcomes when undergoing orthotopic liver transplantation (OLT); however, noninvasive screening for CAD in this population is less sensitive. In an attempt to identify redundancy, we reviewed our experience among patients undergoing CAD screening as part of their OLT evaluation between May 2009 and February 2014. Demographic, clinical, and procedural characteristics were analyzed. Of the total number of screened patients (n=132), initial screening was more common via stress testing (n=100; 75.8%) than coronary angiography (n=32; 24.2%). Most with initial stress testing underwent angiography (n=52; 39.4%). Among those undergoing angiography, CAD was common (n=31; 23.5%). Across the entire cohort the number of traditional risk factors was linearly associated with CAD, and those with two or more risk factors were found to have CAD by angiography 50% of the time (OR 1.92; CI 1.07–3.44, p=0.026). Our data supports that CAD is prevalent among pre-OLT patients, especially among those with 2 or more risk factors. Moreover, we identified a lack of uniformity in practice and the need for evidence-based and standardized screening protocols. |
| format | Article |
| id | doaj-art-970603fcfb6644f0b3aad5282ba7d7fa |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-970603fcfb6644f0b3aad5282ba7d7fa2025-02-03T01:30:14ZengWileyJournal of Transplantation2090-00072090-00152016-01-01201610.1155/2016/71872067187206Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant EvaluationBryan C. Lee0Feng Li1Adam J. Hanje2Khalid Mumtaz3Konstantinos D. Boudoulas4Scott M. Lilly5Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADepartment of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADivision of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADivision of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADivision of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADivision of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USACoronary artery disease (CAD) is prevalent in patients with end-stage liver disease and associated with poor outcomes when undergoing orthotopic liver transplantation (OLT); however, noninvasive screening for CAD in this population is less sensitive. In an attempt to identify redundancy, we reviewed our experience among patients undergoing CAD screening as part of their OLT evaluation between May 2009 and February 2014. Demographic, clinical, and procedural characteristics were analyzed. Of the total number of screened patients (n=132), initial screening was more common via stress testing (n=100; 75.8%) than coronary angiography (n=32; 24.2%). Most with initial stress testing underwent angiography (n=52; 39.4%). Among those undergoing angiography, CAD was common (n=31; 23.5%). Across the entire cohort the number of traditional risk factors was linearly associated with CAD, and those with two or more risk factors were found to have CAD by angiography 50% of the time (OR 1.92; CI 1.07–3.44, p=0.026). Our data supports that CAD is prevalent among pre-OLT patients, especially among those with 2 or more risk factors. Moreover, we identified a lack of uniformity in practice and the need for evidence-based and standardized screening protocols.http://dx.doi.org/10.1155/2016/7187206 |
| spellingShingle | Bryan C. Lee Feng Li Adam J. Hanje Khalid Mumtaz Konstantinos D. Boudoulas Scott M. Lilly Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant Evaluation Journal of Transplantation |
| title | Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant Evaluation |
| title_full | Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant Evaluation |
| title_fullStr | Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant Evaluation |
| title_full_unstemmed | Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant Evaluation |
| title_short | Effectively Screening for Coronary Artery Disease in Patients Undergoing Orthotopic Liver Transplant Evaluation |
| title_sort | effectively screening for coronary artery disease in patients undergoing orthotopic liver transplant evaluation |
| url | http://dx.doi.org/10.1155/2016/7187206 |
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