Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience
Objective. To investigate the risk factors, clinical characteristics, treatment modalities, and outcomes in Saudi patients with HCC and propose points for early detection of the disease. Methods. Patients were stratified according to underlying risk factors for the development of HCC. Barcelona Clin...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/1989045 |
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| author | Abdulrahman A. Aljumah Hadi Kuriry Mohammed AlZunaitan Mohammed Al Ghobain Mohamed Al Muaikeel Ashwaq Al Olayan Fahad Azzumeea Bader Almutairi Abduljaleel AlAlwan Hamdan AlGhamdi |
| author_facet | Abdulrahman A. Aljumah Hadi Kuriry Mohammed AlZunaitan Mohammed Al Ghobain Mohamed Al Muaikeel Ashwaq Al Olayan Fahad Azzumeea Bader Almutairi Abduljaleel AlAlwan Hamdan AlGhamdi |
| author_sort | Abdulrahman A. Aljumah |
| collection | DOAJ |
| description | Objective. To investigate the risk factors, clinical characteristics, treatment modalities, and outcomes in Saudi patients with HCC and propose points for early detection of the disease. Methods. Patients were stratified according to underlying risk factors for the development of HCC. Barcelona Clinic Liver Cancer (BCLC) was used for cancer staging. Treatment was classified into surgical resection/liver transplantation; locoregional ablation therapy; transarterial embolization; systemic chemotherapy; and best supportive care. Results. A total of 235 patients were included. Males had higher tumor size and incidence of portal vein thrombosis. Viral hepatitis was a risk factor in 75.7%. The most common BCLC stages were B (34.5%) and A (33.6%), and the most common radiological presentation was a single nodule of less than 5 cm. Metastases were present in 13.2%. Overall, 77 patients (32.8%) underwent a potentially curative treatment as the initial therapy. The most commonly utilized treatment modality was chemoembolization with 113 sessions in 71 patients. The overall median survival was 15.97±27.18 months. Conclusion. HCC in Saudi Arabia is associated with high prevalence of HCV. Potentially curative therapies were underutilized in our patients. Cancer stage BCLC-B was the most frequent (34.5%) followed by BCLC-A (33.6%). The overall median survival was shorter than other studies. |
| format | Article |
| id | doaj-art-96fd3998865040c5b7514183f79cb912 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-96fd3998865040c5b7514183f79cb9122025-02-03T00:59:21ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/19890451989045Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center ExperienceAbdulrahman A. Aljumah0Hadi Kuriry1Mohammed AlZunaitan2Mohammed Al Ghobain3Mohamed Al Muaikeel4Ashwaq Al Olayan5Fahad Azzumeea6Bader Almutairi7Abduljaleel AlAlwan8Hamdan AlGhamdi9Division of Hepatology, Department of Hepatobiliary Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, P.O. Box 22490, Riyadh 11426, Saudi ArabiaDepartment of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, P.O. Box 22490, Riyadh 11426, Saudi ArabiaDepartment of Medicine, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, P.O. Box 22490, Riyadh 11426, Saudi ArabiaKing Saud bin Abdulaziz University for Health Sciences, P.O. Box 22490, Riyadh 11426, Saudi ArabiaKing Saud bin Abdulaziz University for Health Sciences, P.O. Box 22490, Riyadh 11426, Saudi ArabiaKing Saud bin Abdulaziz University for Health Sciences, P.O. Box 22490, Riyadh 11426, Saudi ArabiaKing Saud bin Abdulaziz University for Health Sciences, P.O. Box 22490, Riyadh 11426, Saudi ArabiaKing Saud bin Abdulaziz University for Health Sciences, P.O. Box 22490, Riyadh 11426, Saudi ArabiaDivision of Hepatology, Department of Hepatobiliary Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, P.O. Box 22490, Riyadh 11426, Saudi ArabiaDivision of Hepatology, Department of Hepatobiliary Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, P.O. Box 22490, Riyadh 11426, Saudi ArabiaObjective. To investigate the risk factors, clinical characteristics, treatment modalities, and outcomes in Saudi patients with HCC and propose points for early detection of the disease. Methods. Patients were stratified according to underlying risk factors for the development of HCC. Barcelona Clinic Liver Cancer (BCLC) was used for cancer staging. Treatment was classified into surgical resection/liver transplantation; locoregional ablation therapy; transarterial embolization; systemic chemotherapy; and best supportive care. Results. A total of 235 patients were included. Males had higher tumor size and incidence of portal vein thrombosis. Viral hepatitis was a risk factor in 75.7%. The most common BCLC stages were B (34.5%) and A (33.6%), and the most common radiological presentation was a single nodule of less than 5 cm. Metastases were present in 13.2%. Overall, 77 patients (32.8%) underwent a potentially curative treatment as the initial therapy. The most commonly utilized treatment modality was chemoembolization with 113 sessions in 71 patients. The overall median survival was 15.97±27.18 months. Conclusion. HCC in Saudi Arabia is associated with high prevalence of HCV. Potentially curative therapies were underutilized in our patients. Cancer stage BCLC-B was the most frequent (34.5%) followed by BCLC-A (33.6%). The overall median survival was shorter than other studies.http://dx.doi.org/10.1155/2016/1989045 |
| spellingShingle | Abdulrahman A. Aljumah Hadi Kuriry Mohammed AlZunaitan Mohammed Al Ghobain Mohamed Al Muaikeel Ashwaq Al Olayan Fahad Azzumeea Bader Almutairi Abduljaleel AlAlwan Hamdan AlGhamdi Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience Gastroenterology Research and Practice |
| title | Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience |
| title_full | Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience |
| title_fullStr | Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience |
| title_full_unstemmed | Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience |
| title_short | Clinical Presentation, Risk Factors, and Treatment Modalities of Hepatocellular Carcinoma: A Single Tertiary Care Center Experience |
| title_sort | clinical presentation risk factors and treatment modalities of hepatocellular carcinoma a single tertiary care center experience |
| url | http://dx.doi.org/10.1155/2016/1989045 |
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