Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications
Abstract Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms and signaling pathways. In this review, we delve into the cellular metabolic pathways of copper, highlighting the role of copper in biomolecule synthesis,...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06121-1 |
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| _version_ | 1832585440899629056 |
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| author | Yating Cong Na Li Zixin Zhang Yan Shang Hailong Zhao |
| author_facet | Yating Cong Na Li Zixin Zhang Yan Shang Hailong Zhao |
| author_sort | Yating Cong |
| collection | DOAJ |
| description | Abstract Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms and signaling pathways. In this review, we delve into the cellular metabolic pathways of copper, highlighting the role of copper in biomolecule synthesis, mitochondrial respiration, and antioxidant defense. Furthermore, we elucidate the relationship between cuproptosis-related genes (CRGs) and cancer prognosis, analyzing their expression patterns across various tumor types and their impact on patient outcomes. Our review also uncovers the potential therapeutic applications of copper chelators, copper ionophores, and copper-based nanomaterials in oncology. In addition, we discuss the emerging role of cuproptosis in remodeling the tumor microenvironment, enhancing immune cell infiltration, and converting “cold tumors” into “hot tumors” that respond better to immunotherapy. In short, this review underscores the pivotal importance of cuproptosis in cancer biology and highlights its translational potential as a novel therapeutic target. |
| format | Article |
| id | doaj-art-96f48d8a54464a6f88fad4a9ddd03692 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-96f48d8a54464a6f88fad4a9ddd036922025-01-26T12:50:05ZengBMCJournal of Translational Medicine1479-58762025-01-0123111710.1186/s12967-025-06121-1Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applicationsYating Cong0Na Li1Zixin Zhang2Yan Shang3Hailong Zhao4Department of Pathophysiology, Zunyi Medical UniversityDepartment of Pathophysiology, Zunyi Medical UniversityDepartment of Pathophysiology, Zunyi Medical UniversityDepartment of Pathophysiology, Zunyi Medical UniversityDepartment of Pathophysiology, Zunyi Medical UniversityAbstract Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms and signaling pathways. In this review, we delve into the cellular metabolic pathways of copper, highlighting the role of copper in biomolecule synthesis, mitochondrial respiration, and antioxidant defense. Furthermore, we elucidate the relationship between cuproptosis-related genes (CRGs) and cancer prognosis, analyzing their expression patterns across various tumor types and their impact on patient outcomes. Our review also uncovers the potential therapeutic applications of copper chelators, copper ionophores, and copper-based nanomaterials in oncology. In addition, we discuss the emerging role of cuproptosis in remodeling the tumor microenvironment, enhancing immune cell infiltration, and converting “cold tumors” into “hot tumors” that respond better to immunotherapy. In short, this review underscores the pivotal importance of cuproptosis in cancer biology and highlights its translational potential as a novel therapeutic target.https://doi.org/10.1186/s12967-025-06121-1CuproptosisCopper metabolismCancer prognosisImmunotherapy |
| spellingShingle | Yating Cong Na Li Zixin Zhang Yan Shang Hailong Zhao Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications Journal of Translational Medicine Cuproptosis Copper metabolism Cancer prognosis Immunotherapy |
| title | Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications |
| title_full | Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications |
| title_fullStr | Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications |
| title_full_unstemmed | Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications |
| title_short | Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications |
| title_sort | cuproptosis molecular mechanisms cancer prognosis and therapeutic applications |
| topic | Cuproptosis Copper metabolism Cancer prognosis Immunotherapy |
| url | https://doi.org/10.1186/s12967-025-06121-1 |
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