Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil
Human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) is an important public health issue. In Brazil, low to intermediate resistance levels have been described. We assessed 225 HIV-1 infected, antiretroviral naïve individuals, from HIV Reference Centers at two major metropoli...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2013/878237 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553959323074560 |
|---|---|
| author | Joao Leandro Paula Ferreira Rosangela Rodrigues Andre Minhoto Lança Valeria Correia de Almeida Simone Queiroz Rocha Taisa Grotta Ragazzo Denise Lotufo Estevam Luis Fernando de Macedo Brigido |
| author_facet | Joao Leandro Paula Ferreira Rosangela Rodrigues Andre Minhoto Lança Valeria Correia de Almeida Simone Queiroz Rocha Taisa Grotta Ragazzo Denise Lotufo Estevam Luis Fernando de Macedo Brigido |
| author_sort | Joao Leandro Paula Ferreira |
| collection | DOAJ |
| description | Human immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) is an important public health issue. In Brazil, low to intermediate resistance levels have been described. We assessed 225 HIV-1 infected, antiretroviral naïve individuals, from HIV Reference Centers at two major metropolitan areas of Sao Paulo (Sao Paulo and Campinas), the state that concentrates most of the Brazilian Aids cases. TDR was analyzed by Stanford Calibrated Population Resistance criteria (CPR), and mutations were observed in 17 individuals (7.6%, 95% CI: 4.5%–11.9%). Seventy-six percent of genomes (13/17) with TDR carried a nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance mutation, mostly K103N/S (9/13, 69%), potentially compromising the preferential first-line therapy suggested by the Brazilian HIV Treatment Guideline that recommends efavirenz-based combinations. Moreover, 6/17 (35%) had multiple mutations associated with resistance to one or more classes. HIV-1 B was the prevalent subtype (80%); other subtypes include HIV-1 F and C, mosaics BC, BF, and single cases of subtype A1 and CRF02_AG. The HIV Reference Center of Campinas presented more cases with TDR, with a significant association of TDR with clade B infection (P<0.05). |
| format | Article |
| id | doaj-art-96ecdffce3a24a60847b22228b9bc5e1 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-96ecdffce3a24a60847b22228b9bc5e12025-02-03T05:52:46ZengWileyAdvances in Virology1687-86391687-86472013-01-01201310.1155/2013/878237878237Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, BrazilJoao Leandro Paula Ferreira0Rosangela Rodrigues1Andre Minhoto Lança2Valeria Correia de Almeida3Simone Queiroz Rocha4Taisa Grotta Ragazzo5Denise Lotufo Estevam6Luis Fernando de Macedo Brigido7Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, Avenue Dr. Arnaldo 355, 01246-902 São Paulo, SP, BrazilLaboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, Avenue Dr. Arnaldo 355, 01246-902 São Paulo, SP, BrazilLaboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, Avenue Dr. Arnaldo 355, 01246-902 São Paulo, SP, BrazilCentro de Referência em DST/Aids, 13013-051 Campinas, SP, BrazilCentro de Referência e Treinamento em DST/Aids, 04121-000 São Paulo, SP, BrazilCentro de Referência em DST/Aids, 13013-051 Campinas, SP, BrazilCentro de Referência e Treinamento em DST/Aids, 04121-000 São Paulo, SP, BrazilLaboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, Avenue Dr. Arnaldo 355, 01246-902 São Paulo, SP, BrazilHuman immunodeficiency virus type 1 (HIV-1) transmitted drug resistance (TDR) is an important public health issue. In Brazil, low to intermediate resistance levels have been described. We assessed 225 HIV-1 infected, antiretroviral naïve individuals, from HIV Reference Centers at two major metropolitan areas of Sao Paulo (Sao Paulo and Campinas), the state that concentrates most of the Brazilian Aids cases. TDR was analyzed by Stanford Calibrated Population Resistance criteria (CPR), and mutations were observed in 17 individuals (7.6%, 95% CI: 4.5%–11.9%). Seventy-six percent of genomes (13/17) with TDR carried a nonnucleoside reverse transcriptase inhibitor (NNRTI) resistance mutation, mostly K103N/S (9/13, 69%), potentially compromising the preferential first-line therapy suggested by the Brazilian HIV Treatment Guideline that recommends efavirenz-based combinations. Moreover, 6/17 (35%) had multiple mutations associated with resistance to one or more classes. HIV-1 B was the prevalent subtype (80%); other subtypes include HIV-1 F and C, mosaics BC, BF, and single cases of subtype A1 and CRF02_AG. The HIV Reference Center of Campinas presented more cases with TDR, with a significant association of TDR with clade B infection (P<0.05).http://dx.doi.org/10.1155/2013/878237 |
| spellingShingle | Joao Leandro Paula Ferreira Rosangela Rodrigues Andre Minhoto Lança Valeria Correia de Almeida Simone Queiroz Rocha Taisa Grotta Ragazzo Denise Lotufo Estevam Luis Fernando de Macedo Brigido Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil Advances in Virology |
| title | Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil |
| title_full | Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil |
| title_fullStr | Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil |
| title_full_unstemmed | Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil |
| title_short | Transmitted Drug Resistance among People Living with HIV/Aids at Major Cities of Sao Paulo State, Brazil |
| title_sort | transmitted drug resistance among people living with hiv aids at major cities of sao paulo state brazil |
| url | http://dx.doi.org/10.1155/2013/878237 |
| work_keys_str_mv | AT joaoleandropaulaferreira transmitteddrugresistanceamongpeoplelivingwithhivaidsatmajorcitiesofsaopaulostatebrazil AT rosangelarodrigues transmitteddrugresistanceamongpeoplelivingwithhivaidsatmajorcitiesofsaopaulostatebrazil AT andreminhotolanca transmitteddrugresistanceamongpeoplelivingwithhivaidsatmajorcitiesofsaopaulostatebrazil AT valeriacorreiadealmeida transmitteddrugresistanceamongpeoplelivingwithhivaidsatmajorcitiesofsaopaulostatebrazil AT simonequeirozrocha transmitteddrugresistanceamongpeoplelivingwithhivaidsatmajorcitiesofsaopaulostatebrazil AT taisagrottaragazzo transmitteddrugresistanceamongpeoplelivingwithhivaidsatmajorcitiesofsaopaulostatebrazil AT deniselotufoestevam transmitteddrugresistanceamongpeoplelivingwithhivaidsatmajorcitiesofsaopaulostatebrazil AT luisfernandodemacedobrigido transmitteddrugresistanceamongpeoplelivingwithhivaidsatmajorcitiesofsaopaulostatebrazil |