Chronic intermittent fasting impairs β cell maturation and function in adolescent mice
Summary: Intermittent fasting (IF) is a nutritional lifestyle intervention with broad metabolic benefits, but whether the impact of IF depends on the individual’s age is unclear. Here, we investigated the effects of IF on systemic metabolism and β cell function in old, middle-aged, and young mice. S...
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Elsevier
2025-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724015766 |
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| author | Leonardo Matta Peter Weber Suheda Erener Alina Walth-Hummel Daniela Hass Lea K. Bühler Katarina Klepac Julia Szendroedi Joel Guerra Maria Rohm Michael Sterr Heiko Lickert Alexander Bartelt Stephan Herzig |
| author_facet | Leonardo Matta Peter Weber Suheda Erener Alina Walth-Hummel Daniela Hass Lea K. Bühler Katarina Klepac Julia Szendroedi Joel Guerra Maria Rohm Michael Sterr Heiko Lickert Alexander Bartelt Stephan Herzig |
| author_sort | Leonardo Matta |
| collection | DOAJ |
| description | Summary: Intermittent fasting (IF) is a nutritional lifestyle intervention with broad metabolic benefits, but whether the impact of IF depends on the individual’s age is unclear. Here, we investigated the effects of IF on systemic metabolism and β cell function in old, middle-aged, and young mice. Short-term IF improves glucose homeostasis across all age groups without altering islet function and morphology. In contrast, while chronic IF is beneficial for adult mice, it results in impaired β cell function in the young. Using single-cell RNA sequencing (scRNA-seq), we delineate that the β cell maturation and function scores are reduced in young mice. In human islets, a similar pattern is observed in type 1 (T1D), but not type 2 (T2D), diabetes, suggesting that the impact of chronic IF in adolescence is linked to the development of β cell dysfunction. Our study suggests considering the duration of IF in younger persons, as it may worsen rather than reduce diabetes outcomes. |
| format | Article |
| id | doaj-art-96cd0abe0cf24cc1ac3d498cbf96ed26 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-96cd0abe0cf24cc1ac3d498cbf96ed262025-01-20T04:17:23ZengElsevierCell Reports2211-12472025-02-01442115225Chronic intermittent fasting impairs β cell maturation and function in adolescent miceLeonardo Matta0Peter Weber1Suheda Erener2Alina Walth-Hummel3Daniela Hass4Lea K. Bühler5Katarina Klepac6Julia Szendroedi7Joel Guerra8Maria Rohm9Michael Sterr10Heiko Lickert11Alexander Bartelt12Stephan Herzig13Institute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg 69120, Germany; German Center for Diabetes Research, 85764 Neuherberg, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg 69120, Germany; German Center for Diabetes Research, 85764 Neuherberg, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg 69120, Germany; German Center for Diabetes Research, 85764 Neuherberg, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg 69120, Germany; German Center for Diabetes Research, 85764 Neuherberg, GermanyGerman Center for Diabetes Research, 85764 Neuherberg, Germany; Institute of Diabetes and Regeneration Research, Helmholtz Munich, Neuherberg, GermanyGerman Center for Diabetes Research, 85764 Neuherberg, Germany; Institute of Diabetes and Regeneration Research, Helmholtz Munich, Neuherberg, Germany; School of Medicine, Technical University of Munich (TUM), Munich, GermanyInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; German Center for Diabetes Research, 85764 Neuherberg, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Technische Universität München, Munich, Germany; Chair of Translational Nutritional Medicine, TUM School of Life Sciences, Research Department of Molecular Life Sciences, Technical University of Munich, Freising, Germany; Else Kröner Fresenius Center for Nutritional Medicine, Technical University of Munich, Munich, Germany; Corresponding authorInstitute for Diabetes and Cancer (IDC), Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute for Cardiovascular Prevention (IPEK), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg 69120, Germany; German Center for Diabetes Research, 85764 Neuherberg, Germany; German Center for Cardiovascular Research, Partner Site Munich Heart Alliance, Technische Universität München, Munich, Germany; Chair Molecular Metabolic Control, Technical University Munich, Munich 80333, Germany; Corresponding authorSummary: Intermittent fasting (IF) is a nutritional lifestyle intervention with broad metabolic benefits, but whether the impact of IF depends on the individual’s age is unclear. Here, we investigated the effects of IF on systemic metabolism and β cell function in old, middle-aged, and young mice. Short-term IF improves glucose homeostasis across all age groups without altering islet function and morphology. In contrast, while chronic IF is beneficial for adult mice, it results in impaired β cell function in the young. Using single-cell RNA sequencing (scRNA-seq), we delineate that the β cell maturation and function scores are reduced in young mice. In human islets, a similar pattern is observed in type 1 (T1D), but not type 2 (T2D), diabetes, suggesting that the impact of chronic IF in adolescence is linked to the development of β cell dysfunction. Our study suggests considering the duration of IF in younger persons, as it may worsen rather than reduce diabetes outcomes.http://www.sciencedirect.com/science/article/pii/S2211124724015766CP: Metabolism |
| spellingShingle | Leonardo Matta Peter Weber Suheda Erener Alina Walth-Hummel Daniela Hass Lea K. Bühler Katarina Klepac Julia Szendroedi Joel Guerra Maria Rohm Michael Sterr Heiko Lickert Alexander Bartelt Stephan Herzig Chronic intermittent fasting impairs β cell maturation and function in adolescent mice Cell Reports CP: Metabolism |
| title | Chronic intermittent fasting impairs β cell maturation and function in adolescent mice |
| title_full | Chronic intermittent fasting impairs β cell maturation and function in adolescent mice |
| title_fullStr | Chronic intermittent fasting impairs β cell maturation and function in adolescent mice |
| title_full_unstemmed | Chronic intermittent fasting impairs β cell maturation and function in adolescent mice |
| title_short | Chronic intermittent fasting impairs β cell maturation and function in adolescent mice |
| title_sort | chronic intermittent fasting impairs β cell maturation and function in adolescent mice |
| topic | CP: Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724015766 |
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