Exposure of Xenogeneic Biomaterial to the Oral Environment and Its Impact on Tissue Healing of Immediate Dental Implants: A Case–Control Study
This study evaluated the clinical and tomographic outcomes of socket healing. Immediate implants were placed in the molar area, and the gap was filled with either deproteinized bovine bone mineral (B) or collagen matrix (BM), n = 14/group. Scores of epithelization healing, immunoassay for VEGF, IL-1...
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2025-01-01
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| author | Valessa F. Carvalho João Garcez-Filho Roberta Okamoto Paula B. Frigério Priscila L. Santos Arthur B. Novaes Junior Michel R. Messora Mario Taba Jr |
| author_facet | Valessa F. Carvalho João Garcez-Filho Roberta Okamoto Paula B. Frigério Priscila L. Santos Arthur B. Novaes Junior Michel R. Messora Mario Taba Jr |
| author_sort | Valessa F. Carvalho |
| collection | DOAJ |
| description | This study evaluated the clinical and tomographic outcomes of socket healing. Immediate implants were placed in the molar area, and the gap was filled with either deproteinized bovine bone mineral (B) or collagen matrix (BM), n = 14/group. Scores of epithelization healing, immunoassay for VEGF, IL-1β, and FGF from wound exudate, keratinized mucosa variation (ΔKM), and bone levels were evaluated. The B group had slower tissue maturation than BM (<i>p</i> < 0.05), but gingival epithelialization was similar (<i>p</i> > 0.05). At the restorative phase, the B group exhibited greater ΔKM at prosthesis installation—1 to 2 months of postoperative (increase of 0.29 mm) compared to the BM group (reduction of −1.5 mm) (<i>p</i> < 0.05). Inflammatory tissue responses as well as vertical and horizontal bone remodeling were similar (<i>p</i> > 0.05). Crestal bone remodeling was limited to less than 0.8 mm for both groups. Taken together, the B and BM groups behaved similarly and promoted stable conditions for biomaterial incorporation in the socket healing after immediate implant placement in molar areas. |
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| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-96c8fc8a5e744f3e99e34136264575952025-01-24T13:21:37ZengMDPI AGApplied Sciences2076-34172025-01-0115299310.3390/app15020993Exposure of Xenogeneic Biomaterial to the Oral Environment and Its Impact on Tissue Healing of Immediate Dental Implants: A Case–Control StudyValessa F. Carvalho0João Garcez-Filho1Roberta Okamoto2Paula B. Frigério3Priscila L. Santos4Arthur B. Novaes Junior5Michel R. Messora6Mario Taba Jr7Department of Oral Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo—USP, Avenida do Café S/N, Ribeirao Preto 14040-904, BrazilIndependent Researcher, Private Practice, Aracaju 49015-230, BrazilDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University Júlio de Mesquita Filho—UNESP, Araçatuba 16015-050, BrazilDepartment of Basic Sciences, School of Dentistry of Araçatuba, São Paulo State University Júlio de Mesquita Filho—UNESP, Araçatuba 16015-050, BrazilHealth Sciences Graduate Program, Federal University of Sergipe, Cláudio Batista Street, 505, Palestina, Aracaju 49060-108, BrazilDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo—USP, Avenida do Café S/N, Ribeirao Preto 14040-904, BrazilDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo—USP, Avenida do Café S/N, Ribeirao Preto 14040-904, BrazilDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirão Preto, University of São Paulo—USP, Avenida do Café S/N, Ribeirao Preto 14040-904, BrazilThis study evaluated the clinical and tomographic outcomes of socket healing. Immediate implants were placed in the molar area, and the gap was filled with either deproteinized bovine bone mineral (B) or collagen matrix (BM), n = 14/group. Scores of epithelization healing, immunoassay for VEGF, IL-1β, and FGF from wound exudate, keratinized mucosa variation (ΔKM), and bone levels were evaluated. The B group had slower tissue maturation than BM (<i>p</i> < 0.05), but gingival epithelialization was similar (<i>p</i> > 0.05). At the restorative phase, the B group exhibited greater ΔKM at prosthesis installation—1 to 2 months of postoperative (increase of 0.29 mm) compared to the BM group (reduction of −1.5 mm) (<i>p</i> < 0.05). Inflammatory tissue responses as well as vertical and horizontal bone remodeling were similar (<i>p</i> > 0.05). Crestal bone remodeling was limited to less than 0.8 mm for both groups. Taken together, the B and BM groups behaved similarly and promoted stable conditions for biomaterial incorporation in the socket healing after immediate implant placement in molar areas.https://www.mdpi.com/2076-3417/15/2/993alveolar bone lossbiomaterialsbone substitutedental implantkeratinmolar area |
| spellingShingle | Valessa F. Carvalho João Garcez-Filho Roberta Okamoto Paula B. Frigério Priscila L. Santos Arthur B. Novaes Junior Michel R. Messora Mario Taba Jr Exposure of Xenogeneic Biomaterial to the Oral Environment and Its Impact on Tissue Healing of Immediate Dental Implants: A Case–Control Study Applied Sciences alveolar bone loss biomaterials bone substitute dental implant keratin molar area |
| title | Exposure of Xenogeneic Biomaterial to the Oral Environment and Its Impact on Tissue Healing of Immediate Dental Implants: A Case–Control Study |
| title_full | Exposure of Xenogeneic Biomaterial to the Oral Environment and Its Impact on Tissue Healing of Immediate Dental Implants: A Case–Control Study |
| title_fullStr | Exposure of Xenogeneic Biomaterial to the Oral Environment and Its Impact on Tissue Healing of Immediate Dental Implants: A Case–Control Study |
| title_full_unstemmed | Exposure of Xenogeneic Biomaterial to the Oral Environment and Its Impact on Tissue Healing of Immediate Dental Implants: A Case–Control Study |
| title_short | Exposure of Xenogeneic Biomaterial to the Oral Environment and Its Impact on Tissue Healing of Immediate Dental Implants: A Case–Control Study |
| title_sort | exposure of xenogeneic biomaterial to the oral environment and its impact on tissue healing of immediate dental implants a case control study |
| topic | alveolar bone loss biomaterials bone substitute dental implant keratin molar area |
| url | https://www.mdpi.com/2076-3417/15/2/993 |
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