Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells
Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic m...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2006.318 |
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| author | Adele Murrell |
| author_facet | Adele Murrell |
| author_sort | Adele Murrell |
| collection | DOAJ |
| description | Imprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. This review summarises what we know about imprinting in stem cells and how loss of imprinting may contribute to neoplasia. |
| format | Article |
| id | doaj-art-96c899bc8e384fddbb1b73f3a75b467f |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-96c899bc8e384fddbb1b73f3a75b467f2025-02-03T01:10:17ZengWileyThe Scientific World Journal1537-744X2006-01-0161888191010.1100/tsw.2006.318Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic CellsAdele Murrell0Department of Oncology, University of Cambridge, MRC-Hutchison Centre, Hills Road Cambridge CB2 2XZ, UKImprinted genes are a subset of genes that are expressed from only one of the parental alleles. The majority of imprinted genes have roles in growth regulation and are, therefore, potential oncogenes or tumour suppressors. Cancer is a disease of aberrant cell growth and is characterised by genetic mutations and epigenetic changes such as DNA methylation. The mechanisms whereby imprinting is maintained in somatic cells and then erased and reset in the germline parallels epigenetic changes that cancer cells undergo. This review summarises what we know about imprinting in stem cells and how loss of imprinting may contribute to neoplasia.http://dx.doi.org/10.1100/tsw.2006.318 |
| spellingShingle | Adele Murrell Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells The Scientific World Journal |
| title | Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells |
| title_full | Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells |
| title_fullStr | Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells |
| title_full_unstemmed | Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells |
| title_short | Genomic Imprinting and Cancer: From Primordial Germ Cells to Somatic Cells |
| title_sort | genomic imprinting and cancer from primordial germ cells to somatic cells |
| url | http://dx.doi.org/10.1100/tsw.2006.318 |
| work_keys_str_mv | AT adelemurrell genomicimprintingandcancerfromprimordialgermcellstosomaticcells |