Ferroptosis plays a role in osteoarthritis
In recent years, ferroptosis has been identified as a novel type of regulated cell death. As a cell death process, it differs from other processes like necrosis and apoptosis in the expression of morphology, biochemistry, and genetics. Ferroptosis provides a new view of programmed cell death. It is...
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| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | All Life |
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| Online Access: | http://dx.doi.org/10.1080/26895293.2024.2391292 |
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| author | Ruba Altahla Jamal Alshorman Xu Tao |
| author_facet | Ruba Altahla Jamal Alshorman Xu Tao |
| author_sort | Ruba Altahla |
| collection | DOAJ |
| description | In recent years, ferroptosis has been identified as a novel type of regulated cell death. As a cell death process, it differs from other processes like necrosis and apoptosis in the expression of morphology, biochemistry, and genetics. Ferroptosis provides a new view of programmed cell death. It is initiated by the oxidation of lipids, reactive oxygen species (ROS) formation and iron buildup within cells, leading to their demise. The identification of these biochemical events triggering ferroptosis has expanded understanding of controlled cellular suicide. A significant role of ferroptosis in osteoarthritis (OA) has been reported in recent studies. Both OA and ferroptosis exhibit anomalies in metabolism of iron, oxidation of lipids, and mitochondrial dysfunction. Nonetheless, our understanding of the specific genes involved in regulating ferroptosis in the context of OA is currently limited. Expanding our knowledge in this area could have profound implications for effectively managing and treating OA. This review offers an in-depth exploration of the molecular processes associated with ferroptosis. Furthermore, we discuss the roles of ferrioptosis in different aspects of osteoarthritis, encompassing the degradation of cartilage, synovitis, dysfunction of chondrocytes, and the manifestation of OA-related pain. We highlight the potential of targeting ferroptosis for OA treatment. |
| format | Article |
| id | doaj-art-96c667bd512743f7b76a645236727110 |
| institution | Kabale University |
| issn | 2689-5307 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | All Life |
| spelling | doaj-art-96c667bd512743f7b76a6452367271102025-01-20T14:38:00ZengTaylor & Francis GroupAll Life2689-53072024-12-01170110.1080/26895293.2024.23912922391292Ferroptosis plays a role in osteoarthritisRuba Altahla0Jamal Alshorman1Xu Tao2Huazhong University of Science and TechnologyHubei University of Science and TechnologyHuazhong University of Science and TechnologyIn recent years, ferroptosis has been identified as a novel type of regulated cell death. As a cell death process, it differs from other processes like necrosis and apoptosis in the expression of morphology, biochemistry, and genetics. Ferroptosis provides a new view of programmed cell death. It is initiated by the oxidation of lipids, reactive oxygen species (ROS) formation and iron buildup within cells, leading to their demise. The identification of these biochemical events triggering ferroptosis has expanded understanding of controlled cellular suicide. A significant role of ferroptosis in osteoarthritis (OA) has been reported in recent studies. Both OA and ferroptosis exhibit anomalies in metabolism of iron, oxidation of lipids, and mitochondrial dysfunction. Nonetheless, our understanding of the specific genes involved in regulating ferroptosis in the context of OA is currently limited. Expanding our knowledge in this area could have profound implications for effectively managing and treating OA. This review offers an in-depth exploration of the molecular processes associated with ferroptosis. Furthermore, we discuss the roles of ferrioptosis in different aspects of osteoarthritis, encompassing the degradation of cartilage, synovitis, dysfunction of chondrocytes, and the manifestation of OA-related pain. We highlight the potential of targeting ferroptosis for OA treatment.http://dx.doi.org/10.1080/26895293.2024.2391292ferroptosislipid peroxidationironreactive oxygen species (ros)osteoarthritis |
| spellingShingle | Ruba Altahla Jamal Alshorman Xu Tao Ferroptosis plays a role in osteoarthritis All Life ferroptosis lipid peroxidation iron reactive oxygen species (ros) osteoarthritis |
| title | Ferroptosis plays a role in osteoarthritis |
| title_full | Ferroptosis plays a role in osteoarthritis |
| title_fullStr | Ferroptosis plays a role in osteoarthritis |
| title_full_unstemmed | Ferroptosis plays a role in osteoarthritis |
| title_short | Ferroptosis plays a role in osteoarthritis |
| title_sort | ferroptosis plays a role in osteoarthritis |
| topic | ferroptosis lipid peroxidation iron reactive oxygen species (ros) osteoarthritis |
| url | http://dx.doi.org/10.1080/26895293.2024.2391292 |
| work_keys_str_mv | AT rubaaltahla ferroptosisplaysaroleinosteoarthritis AT jamalalshorman ferroptosisplaysaroleinosteoarthritis AT xutao ferroptosisplaysaroleinosteoarthritis |