Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent Advancements
Transcranial direct current stimulation (tDCS) is a promising technique to treat a wide range of neurological conditions including stroke. The pathological processes following stroke may provide an exemplary system to investigate how tDCS promotes neuronal plasticity and functional recovery. Changes...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2013/170256 |
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| _version_ | 1832546822532366336 |
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| author | Andrea Gomez Palacio Schjetnan Jamshid Faraji Gerlinde A. Metz Masami Tatsuno Artur Luczak |
| author_facet | Andrea Gomez Palacio Schjetnan Jamshid Faraji Gerlinde A. Metz Masami Tatsuno Artur Luczak |
| author_sort | Andrea Gomez Palacio Schjetnan |
| collection | DOAJ |
| description | Transcranial direct current stimulation (tDCS) is a promising technique to treat a wide range of neurological conditions including stroke. The pathological processes following stroke may provide an exemplary system to investigate how tDCS promotes neuronal plasticity and functional recovery. Changes in synaptic function after stroke, such as reduced excitability, formation of aberrant connections, and deregulated plastic modifications, have been postulated to impede recovery from stroke. However, if tDCS could counteract these negative changes by influencing the system’s neurophysiology, it would contribute to the formation of functionally meaningful connections and the maintenance of existing pathways. This paper is aimed at providing a review of underlying mechanisms of tDCS and its application to stroke. In addition, to maximize the effectiveness of tDCS in stroke rehabilitation, future research needs to determine the optimal stimulation protocols and parameters. We discuss how stimulation parameters could be optimized based on electrophysiological activity. In particular, we propose that cortical synchrony may represent a biomarker of tDCS efficacy to indicate communication between affected areas. Understanding the mechanisms by which tDCS affects the neural substrate after stroke and finding ways to optimize tDCS for each patient are key to effective rehabilitation approaches. |
| format | Article |
| id | doaj-art-96c517acd9f243b2b1da984cd4e080a8 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-96c517acd9f243b2b1da984cd4e080a82025-02-03T06:46:57ZengWileyStroke Research and Treatment2090-81052042-00562013-01-01201310.1155/2013/170256170256Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent AdvancementsAndrea Gomez Palacio Schjetnan0Jamshid Faraji1Gerlinde A. Metz2Masami Tatsuno3Artur Luczak4Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, T1K 3M4, CanadaTranscranial direct current stimulation (tDCS) is a promising technique to treat a wide range of neurological conditions including stroke. The pathological processes following stroke may provide an exemplary system to investigate how tDCS promotes neuronal plasticity and functional recovery. Changes in synaptic function after stroke, such as reduced excitability, formation of aberrant connections, and deregulated plastic modifications, have been postulated to impede recovery from stroke. However, if tDCS could counteract these negative changes by influencing the system’s neurophysiology, it would contribute to the formation of functionally meaningful connections and the maintenance of existing pathways. This paper is aimed at providing a review of underlying mechanisms of tDCS and its application to stroke. In addition, to maximize the effectiveness of tDCS in stroke rehabilitation, future research needs to determine the optimal stimulation protocols and parameters. We discuss how stimulation parameters could be optimized based on electrophysiological activity. In particular, we propose that cortical synchrony may represent a biomarker of tDCS efficacy to indicate communication between affected areas. Understanding the mechanisms by which tDCS affects the neural substrate after stroke and finding ways to optimize tDCS for each patient are key to effective rehabilitation approaches.http://dx.doi.org/10.1155/2013/170256 |
| spellingShingle | Andrea Gomez Palacio Schjetnan Jamshid Faraji Gerlinde A. Metz Masami Tatsuno Artur Luczak Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent Advancements Stroke Research and Treatment |
| title | Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent Advancements |
| title_full | Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent Advancements |
| title_fullStr | Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent Advancements |
| title_full_unstemmed | Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent Advancements |
| title_short | Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent Advancements |
| title_sort | transcranial direct current stimulation in stroke rehabilitation a review of recent advancements |
| url | http://dx.doi.org/10.1155/2013/170256 |
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