Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in Men
Oxidative stress and inflammation contribute to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD), and the control of lipid status by statins may help to stop the progression of NAFLD. We hypothesized that the addition of antioxidant vitamins C and E to atorvastatin therap...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2018/4673061 |
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| author | Nikola Hadzi-Petrushev Katerina Dimovska Nikola Jankulovski Dine Mitrov Mitko Mladenov |
| author_facet | Nikola Hadzi-Petrushev Katerina Dimovska Nikola Jankulovski Dine Mitrov Mitko Mladenov |
| author_sort | Nikola Hadzi-Petrushev |
| collection | DOAJ |
| description | Oxidative stress and inflammation contribute to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD), and the control of lipid status by statins may help to stop the progression of NAFLD. We hypothesized that the addition of antioxidant vitamins C and E to atorvastatin therapy is associated with improved serum enzyme antioxidant status. NAFLD-related serum parameters and the activity of antioxidant enzymes, before and after 3 months of treatment, were determined in patients receiving atorvastatin alone or atorvastatin plus antioxidants. Compared to healthy controls, the patients, before receiving therapy, had increased catalase and glutathione reductase, with no significant difference in glutathione peroxidase activity. After the treatment, the levels of all three antioxidant markers were reduced to the same degree in both groups of patients, indicating therapy-induced lower level of reactive oxygen species production and/or improved nonenzymatic antioxidant mechanisms. Both therapies led to the normalization of the serum lipid profile and aminotransferase levels in the patients, but the reduction in CRP, although significant, did not reduce levels to those of the controls. The obtained results favor the notion that therapy with atorvastatin alone is equally efficient during the early stages of NAFLD, regardless of the addition of antioxidant vitamins. This trial is registered with TCTR20180425001. |
| format | Article |
| id | doaj-art-96a98ef7b33d40fca1efac2e8d14cc70 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-96a98ef7b33d40fca1efac2e8d14cc702025-02-03T01:21:35ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422018-01-01201810.1155/2018/46730614673061Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in MenNikola Hadzi-Petrushev0Katerina Dimovska1Nikola Jankulovski2Dine Mitrov3Mitko Mladenov4Department of Physiology, Faculty of Natural Sciences and Mathematics, “Ss. Cyril and Methodius” University, Skopje, MacedoniaDepartment of Physiology, Faculty of Natural Sciences and Mathematics, “Ss. Cyril and Methodius” University, Skopje, MacedoniaDepartment of Abdominal Surgery, Faculty of Medicine, “Ss. Cyril and Methodius” University, Skopje, MacedoniaDepartment of Radiology and Physical Therapy and Department of Internal Diseases in Ruminants, Faculty of Veterinary Medicine, “Ss. Cyril and Methodius” University, Skopje, MacedoniaDepartment of Physiology, Faculty of Natural Sciences and Mathematics, “Ss. Cyril and Methodius” University, Skopje, MacedoniaOxidative stress and inflammation contribute to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD), and the control of lipid status by statins may help to stop the progression of NAFLD. We hypothesized that the addition of antioxidant vitamins C and E to atorvastatin therapy is associated with improved serum enzyme antioxidant status. NAFLD-related serum parameters and the activity of antioxidant enzymes, before and after 3 months of treatment, were determined in patients receiving atorvastatin alone or atorvastatin plus antioxidants. Compared to healthy controls, the patients, before receiving therapy, had increased catalase and glutathione reductase, with no significant difference in glutathione peroxidase activity. After the treatment, the levels of all three antioxidant markers were reduced to the same degree in both groups of patients, indicating therapy-induced lower level of reactive oxygen species production and/or improved nonenzymatic antioxidant mechanisms. Both therapies led to the normalization of the serum lipid profile and aminotransferase levels in the patients, but the reduction in CRP, although significant, did not reduce levels to those of the controls. The obtained results favor the notion that therapy with atorvastatin alone is equally efficient during the early stages of NAFLD, regardless of the addition of antioxidant vitamins. This trial is registered with TCTR20180425001.http://dx.doi.org/10.1155/2018/4673061 |
| spellingShingle | Nikola Hadzi-Petrushev Katerina Dimovska Nikola Jankulovski Dine Mitrov Mitko Mladenov Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in Men Advances in Pharmacological Sciences |
| title | Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in Men |
| title_full | Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in Men |
| title_fullStr | Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in Men |
| title_full_unstemmed | Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in Men |
| title_short | Supplementation with Alpha-Tocopherol and Ascorbic Acid to Nonalcoholic Fatty Liver Disease’s Statin Therapy in Men |
| title_sort | supplementation with alpha tocopherol and ascorbic acid to nonalcoholic fatty liver disease s statin therapy in men |
| url | http://dx.doi.org/10.1155/2018/4673061 |
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