The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis
Abstract Background Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that leads to lifelong infection and multiple diseases, including HAM/TSP and ATLL. Despite extensive research, the exact pathophysiology of HTLV infection and its related diseases is enigmatic. In this study, we aim...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12985-024-02612-7 |
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| author | Shayan Mardi Maryam Rashidian Fatemeh Bastan Ghazale Molaverdi Sayed-Hamidreza Mozhgani |
| author_facet | Shayan Mardi Maryam Rashidian Fatemeh Bastan Ghazale Molaverdi Sayed-Hamidreza Mozhgani |
| author_sort | Shayan Mardi |
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| description | Abstract Background Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that leads to lifelong infection and multiple diseases, including HAM/TSP and ATLL. Despite extensive research, the exact pathophysiology of HTLV infection and its related diseases is enigmatic. In this study, we aimed to review and analyze the effect of different HLA alleles as protective or predisposing factors in HTLV-1 infection and its progression to related diseases. Method Three databases (PubMed, Web of Science, and Scopus) were searched for eligible studies. Twenty-five papers with 7279 participants were included in the quantitative analysis. The relevant data were extracted, and 198 meta-analyses were conducted on each reported HLA and population. Results The results of our investigation suggest 3 HLAs with preventive effects against HTLV infection, including HLA-B*35, DRB1*09, and DRB1*16. Also, HLA-DQB1*05:01 might prevent HTLV progression to ATLL. In contrast, HLA-DRB1*13 is more prevalent in ATLL patients than HTLV carriers. Additionally, our results propound that carriers of HLA-A*28, B*54, C*07, DQB1*03:01, and DRB1*07:01 are at higher risk, and carriers of HLA-A*30, B*37, B*40, B*44, C*08, DQB1*06:02, and DRB1*15:01 are in lower risk of HTLV progression to HAM/TSP. We concluded that the mentioned HLA alleles are potential biomarkers of HTLV infection and its progression to related diseases. |
| format | Article |
| id | doaj-art-96a31a63335b4dc1a05cdfdf9eeeeabb |
| institution | Kabale University |
| issn | 1743-422X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj-art-96a31a63335b4dc1a05cdfdf9eeeeabb2025-01-26T12:15:19ZengBMCVirology Journal1743-422X2025-01-0122111510.1186/s12985-024-02612-7The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysisShayan Mardi0Maryam Rashidian1Fatemeh Bastan2Ghazale Molaverdi3Sayed-Hamidreza Mozhgani4Student Research Committee, Arak University of Medical SciencesStudent Research Committee, Alborz University of Medical SciencesStudent Research Committee, Alborz University of Medical SciencesStudent Research Committee, Alborz University of Medical SciencesDepartment of Microbiology and Virology, School of Medicine, Alborz University of Medical SciencesAbstract Background Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that leads to lifelong infection and multiple diseases, including HAM/TSP and ATLL. Despite extensive research, the exact pathophysiology of HTLV infection and its related diseases is enigmatic. In this study, we aimed to review and analyze the effect of different HLA alleles as protective or predisposing factors in HTLV-1 infection and its progression to related diseases. Method Three databases (PubMed, Web of Science, and Scopus) were searched for eligible studies. Twenty-five papers with 7279 participants were included in the quantitative analysis. The relevant data were extracted, and 198 meta-analyses were conducted on each reported HLA and population. Results The results of our investigation suggest 3 HLAs with preventive effects against HTLV infection, including HLA-B*35, DRB1*09, and DRB1*16. Also, HLA-DQB1*05:01 might prevent HTLV progression to ATLL. In contrast, HLA-DRB1*13 is more prevalent in ATLL patients than HTLV carriers. Additionally, our results propound that carriers of HLA-A*28, B*54, C*07, DQB1*03:01, and DRB1*07:01 are at higher risk, and carriers of HLA-A*30, B*37, B*40, B*44, C*08, DQB1*06:02, and DRB1*15:01 are in lower risk of HTLV progression to HAM/TSP. We concluded that the mentioned HLA alleles are potential biomarkers of HTLV infection and its progression to related diseases.https://doi.org/10.1186/s12985-024-02612-7HLAATLLHAM/TSP |
| spellingShingle | Shayan Mardi Maryam Rashidian Fatemeh Bastan Ghazale Molaverdi Sayed-Hamidreza Mozhgani The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis Virology Journal HLA ATLL HAM/TSP |
| title | The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis |
| title_full | The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis |
| title_fullStr | The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis |
| title_full_unstemmed | The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis |
| title_short | The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis |
| title_sort | role of human leukocyte antigen in htlv 1 infection and progression to atll and ham tsp a systematic review and meta analysis |
| topic | HLA ATLL HAM/TSP |
| url | https://doi.org/10.1186/s12985-024-02612-7 |
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