Research progress of the immunosuppressive tumor microenvironment in multiple myeloma
Multiple myeloma (MM) is a hematological malignancy originating from the immune system, and the immune microenvironment plays a pivotal role in its pathogenesis and progression. The immune microenvironment not only mediates immune surveillance and response but also contributes to myeloma immune esca...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shanghai Chinese Clinical Medicine Press Co., Ltd.
2025-08-01
|
| Series: | Zhongguo Linchuang Yixue |
| Subjects: | |
| Online Access: | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241022 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849223003323236352 |
|---|---|
| author | Yue WANG Peng LIU |
| author_facet | Yue WANG Peng LIU |
| author_sort | Yue WANG |
| collection | DOAJ |
| description | Multiple myeloma (MM) is a hematological malignancy originating from the immune system, and the immune microenvironment plays a pivotal role in its pathogenesis and progression. The immune microenvironment not only mediates immune surveillance and response but also contributes to myeloma immune escape and target organ damage. Immune dysregulation persists throughout the disease course of MM, facilitating disease progression by conferring survival advantages to tumor cells and promoting immune editing. The interplay among various immune cell populations represents a critical factor in the exacerbation of the malignant biological behavior of myeloma cells. A comprehensive understanding of the mechanisms underlying the interaction between myeloma cells and the microenvironment, as well as their contribution to immune dysregulation and downstream effects, is essential for improving patient therapeutic strategies and prognosis. This paper aims to systematically review the literature on immune cells promoting the formation of an inhibitory MM microenvironment, thereby elucidating the current status of immune escape mechanisms in MM and exploring potential future directions of immunotherapy. |
| format | Article |
| id | doaj-art-969ba51bf7d14b33bc814fa822c08f9e |
| institution | Kabale University |
| issn | 1008-6358 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Shanghai Chinese Clinical Medicine Press Co., Ltd. |
| record_format | Article |
| series | Zhongguo Linchuang Yixue |
| spelling | doaj-art-969ba51bf7d14b33bc814fa822c08f9e2025-08-26T01:29:39ZengShanghai Chinese Clinical Medicine Press Co., Ltd.Zhongguo Linchuang Yixue1008-63582025-08-0132466567410.12025/j.issn.1008-6358.2025.2024102220241022Research progress of the immunosuppressive tumor microenvironment in multiple myelomaYue WANG0Peng LIU1Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Hematology, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaMultiple myeloma (MM) is a hematological malignancy originating from the immune system, and the immune microenvironment plays a pivotal role in its pathogenesis and progression. The immune microenvironment not only mediates immune surveillance and response but also contributes to myeloma immune escape and target organ damage. Immune dysregulation persists throughout the disease course of MM, facilitating disease progression by conferring survival advantages to tumor cells and promoting immune editing. The interplay among various immune cell populations represents a critical factor in the exacerbation of the malignant biological behavior of myeloma cells. A comprehensive understanding of the mechanisms underlying the interaction between myeloma cells and the microenvironment, as well as their contribution to immune dysregulation and downstream effects, is essential for improving patient therapeutic strategies and prognosis. This paper aims to systematically review the literature on immune cells promoting the formation of an inhibitory MM microenvironment, thereby elucidating the current status of immune escape mechanisms in MM and exploring potential future directions of immunotherapy.https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241022multiple myelomaimmune microenvironmentimmunosuppressionimmunoregulation |
| spellingShingle | Yue WANG Peng LIU Research progress of the immunosuppressive tumor microenvironment in multiple myeloma Zhongguo Linchuang Yixue multiple myeloma immune microenvironment immunosuppression immunoregulation |
| title | Research progress of the immunosuppressive tumor microenvironment in multiple myeloma |
| title_full | Research progress of the immunosuppressive tumor microenvironment in multiple myeloma |
| title_fullStr | Research progress of the immunosuppressive tumor microenvironment in multiple myeloma |
| title_full_unstemmed | Research progress of the immunosuppressive tumor microenvironment in multiple myeloma |
| title_short | Research progress of the immunosuppressive tumor microenvironment in multiple myeloma |
| title_sort | research progress of the immunosuppressive tumor microenvironment in multiple myeloma |
| topic | multiple myeloma immune microenvironment immunosuppression immunoregulation |
| url | https://www.c-jcm.com/article/doi/10.12025/j.issn.1008-6358.2025.20241022 |
| work_keys_str_mv | AT yuewang researchprogressoftheimmunosuppressivetumormicroenvironmentinmultiplemyeloma AT pengliu researchprogressoftheimmunosuppressivetumormicroenvironmentinmultiplemyeloma |