Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus

Sex-specific effects of prenatal bisphenol A exposure on transcriptome-interactome profiles of autism candidate genes in neural stem cells from offspring hippocampus

Abstract Bisphenol A (BPA), an endocrine-disrupting chemical, is increasingly linked to the pathogenesis of autism spectrum disorder (ASD). This study investigates the effects of prenatal BPA exposure on neural stem cells (NSCs) from the hippocampi of rat offspring, a brain region critical for neuro...

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Main Authors: Kasidit Kasitipradit, Surangrat Thongkorn, Songphon Kanlayaprasit, Thanit Saeliw, Pattanachat Lertpeerapan, Pawinee Panjabud, Depicha Jindatip, Valerie W. Hu, Takako Kikkawa, Noriko Osumi, Tewarit Sarachana
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Autism spectrum disorder
Bisphenol A
Endocrine-disrupting chemical
Transcriptome
Interactome
Neural stem cells
Online Access:https://doi.org/10.1038/s41598-025-86392-2
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