Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa
Objective: Women with anorexia nervosa (AN) have been shown to demonstrate differences in functional connectivity in brain regions associated with cognitive control, somatosensory processing, and emotion regulation. However, previous studies have been conducted on small samples and have inconsistent...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158225000154 |
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| author | Katrien F.M. Bracké Laura Monteiro Rente Dias Marisha N. Meijer Cathelijne P.M. Steegers Laurinde F. den Heijer Tess van der Harst Marjolein H.G. Dremmen Meike W. Vernooij Gwen C. Dieleman Tonya White |
| author_facet | Katrien F.M. Bracké Laura Monteiro Rente Dias Marisha N. Meijer Cathelijne P.M. Steegers Laurinde F. den Heijer Tess van der Harst Marjolein H.G. Dremmen Meike W. Vernooij Gwen C. Dieleman Tonya White |
| author_sort | Katrien F.M. Bracké |
| collection | DOAJ |
| description | Objective: Women with anorexia nervosa (AN) have been shown to demonstrate differences in functional connectivity in brain regions associated with cognitive control, somatosensory processing, and emotion regulation. However, previous studies have been conducted on small samples and have inconsistent findings. Therefore, this study aimed to identify aberrant brain networks related to the core clinical symptoms of AN and to explore the longitudinal association with clinical outcome in a large population of adolescents experiencing their first episode of AN. Methods: Functional MRI (fMRI) of brain resting-state functional connectivity (RS-FC) of female adolescents with first-onset AN (n = 56) were compared to age- and education-matched typically developing (TD) adolescents (n = 64). To account for the severity of underweight, separate analyses were performed to investigate differences in RS-FC between underweight AN participants and TD adolescents, as well as between underweight (n = 30) and weight-restored AN (n = 26) participants. Clinical outcomes, i.e. body mass index and eating disorder (ED) symptoms, were assessed at baseline and one-year follow-up. Independent component analyses (ICA) were used to extract the brain networks of interest: the default mode (DMN), left and right frontoparietal (FPN), and the insular (IN) networks. Linear regression analyses were conducted to assess differences in RS-FC between AN and TD participants, as well as to assess whether RS-FC was associated with clinical symptoms at baseline and at one-year of follow-up. Two statistical models were used: model 1 adjusted for age and socioeconomic status (SES), and model 2 additionally adjusted for baseline anxiety and depressive symptoms. Results: Underweight AN participants had lower RS-FC between the DMN-IN, as well as between the FPN-IN compared to the TD adolescents. After correction for multiple testing, no significant differences in RS-FC were found between underweight AN participants and weight-restored AN participants, as well as between the whole AN group and the TD group. RS-FC was not associated with the severity of clinical symptoms at baseline nor at one-year of follow-up. Conclusion: AN is associated with changes in RS-FC between the FPN-IN and DMN-IN during the underweight state. These changes in RS-FC were no longer observed in weight-restored AN participants, emphasizing the impact of underweight on RS-FC in AN. Changes in these brain networks may partly explain the impaired cognitive control and difficulties with emotion and behavioral regulation in individuals with AN during the underweight state. |
| format | Article |
| id | doaj-art-9688966b46c241e08a67480ec6f0a566 |
| institution | Kabale University |
| issn | 2213-1582 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj-art-9688966b46c241e08a67480ec6f0a5662025-02-04T04:10:24ZengElsevierNeuroImage: Clinical2213-15822025-01-0145103745Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosaKatrien F.M. Bracké0Laura Monteiro Rente Dias1Marisha N. Meijer2Cathelijne P.M. Steegers3Laurinde F. den Heijer4Tess van der Harst5Marjolein H.G. Dremmen6Meike W. Vernooij7Gwen C. Dieleman8Tonya White9Department of Child and Adolescent Psychiatry/Psychology Erasmus MC-Sophia Children’s Hospital Rotterdam the Netherlands; Department of Radiology and Nuclear Medicine Erasmus MC Rotterdam the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology Erasmus MC-Sophia Children’s Hospital Rotterdam the Netherlands; Faculty of Electrical Engineering, Mathematics and Computer Science at the Delft University of Technology the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology Erasmus MC-Sophia Children’s Hospital Rotterdam the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology Erasmus MC-Sophia Children’s Hospital Rotterdam the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology Erasmus MC-Sophia Children’s Hospital Rotterdam the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology Erasmus MC-Sophia Children’s Hospital Rotterdam the NetherlandsDepartment of Radiology and Nuclear Medicine Erasmus MC Rotterdam the NetherlandsDepartment of Radiology and Nuclear Medicine Erasmus MC Rotterdam the Netherlands; Department of Epidemiology Erasmus MC Rotterdam the NetherlandsDepartment of Child and Adolescent Psychiatry/Psychology Erasmus MC-Sophia Children’s Hospital Rotterdam the Netherlands; Corresponding author at: Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center – Sophia Children’s Hospital, P.O. Box 2060, 3015 GD Rotterdam, The Netherlands.Section on Social and Cognitive Developmental Neuroscience, National Institute of Mental Health Bethesda MD USAObjective: Women with anorexia nervosa (AN) have been shown to demonstrate differences in functional connectivity in brain regions associated with cognitive control, somatosensory processing, and emotion regulation. However, previous studies have been conducted on small samples and have inconsistent findings. Therefore, this study aimed to identify aberrant brain networks related to the core clinical symptoms of AN and to explore the longitudinal association with clinical outcome in a large population of adolescents experiencing their first episode of AN. Methods: Functional MRI (fMRI) of brain resting-state functional connectivity (RS-FC) of female adolescents with first-onset AN (n = 56) were compared to age- and education-matched typically developing (TD) adolescents (n = 64). To account for the severity of underweight, separate analyses were performed to investigate differences in RS-FC between underweight AN participants and TD adolescents, as well as between underweight (n = 30) and weight-restored AN (n = 26) participants. Clinical outcomes, i.e. body mass index and eating disorder (ED) symptoms, were assessed at baseline and one-year follow-up. Independent component analyses (ICA) were used to extract the brain networks of interest: the default mode (DMN), left and right frontoparietal (FPN), and the insular (IN) networks. Linear regression analyses were conducted to assess differences in RS-FC between AN and TD participants, as well as to assess whether RS-FC was associated with clinical symptoms at baseline and at one-year of follow-up. Two statistical models were used: model 1 adjusted for age and socioeconomic status (SES), and model 2 additionally adjusted for baseline anxiety and depressive symptoms. Results: Underweight AN participants had lower RS-FC between the DMN-IN, as well as between the FPN-IN compared to the TD adolescents. After correction for multiple testing, no significant differences in RS-FC were found between underweight AN participants and weight-restored AN participants, as well as between the whole AN group and the TD group. RS-FC was not associated with the severity of clinical symptoms at baseline nor at one-year of follow-up. Conclusion: AN is associated with changes in RS-FC between the FPN-IN and DMN-IN during the underweight state. These changes in RS-FC were no longer observed in weight-restored AN participants, emphasizing the impact of underweight on RS-FC in AN. Changes in these brain networks may partly explain the impaired cognitive control and difficulties with emotion and behavioral regulation in individuals with AN during the underweight state.http://www.sciencedirect.com/science/article/pii/S2213158225000154Anorexia nervosaFunctional network connectivityResting-state networkDefault mode networkFrontoparietalInsula |
| spellingShingle | Katrien F.M. Bracké Laura Monteiro Rente Dias Marisha N. Meijer Cathelijne P.M. Steegers Laurinde F. den Heijer Tess van der Harst Marjolein H.G. Dremmen Meike W. Vernooij Gwen C. Dieleman Tonya White Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa NeuroImage: Clinical Anorexia nervosa Functional network connectivity Resting-state network Default mode network Frontoparietal Insula |
| title | Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa |
| title_full | Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa |
| title_fullStr | Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa |
| title_full_unstemmed | Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa |
| title_short | Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa |
| title_sort | resting state functional brain connectivity in female adolescents with first onset anorexia nervosa |
| topic | Anorexia nervosa Functional network connectivity Resting-state network Default mode network Frontoparietal Insula |
| url | http://www.sciencedirect.com/science/article/pii/S2213158225000154 |
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