The Impact of Incretin-Based Medications on Lipid Metabolism
Pathophysiological pathways that are induced by chronic hyperglycemia negatively impact lipid metabolism. Thus, diabetes is commonly accompanied by varying degrees of dyslipidemia which is itself a major risk factor for further macro- and microvascular diabetes complications such as atherosclerosis...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2021/1815178 |
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| _version_ | 1832547240800944128 |
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| author | Habib Yaribeygi Mina Maleki Alexandra E. Butler Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_facet | Habib Yaribeygi Mina Maleki Alexandra E. Butler Tannaz Jamialahmadi Amirhossein Sahebkar |
| author_sort | Habib Yaribeygi |
| collection | DOAJ |
| description | Pathophysiological pathways that are induced by chronic hyperglycemia negatively impact lipid metabolism. Thus, diabetes is commonly accompanied by varying degrees of dyslipidemia which is itself a major risk factor for further macro- and microvascular diabetes complications such as atherosclerosis and nephropathy. Therefore, normalizing lipid metabolism is an attractive goal for therapy in patients with diabetes. Incretin-based medications are a novel group of antidiabetic agents with potent hypoglycemic effects. While the impact of incretins on glucose metabolism is clear, recent evidence indicates their positive modulatory roles on various aspects of lipid metabolism. Therefore, incretins may offer additional beneficial effects beyond that of glucose normalization. In the current review, how these antidiabetic medications can regulate lipid homeostasis and the possible cellular pathways involved are discussed, incorporating related clinical evidence about incretin effects on lipid homeostasis. |
| format | Article |
| id | doaj-art-967d862f6d4d434ab40da23093173e23 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-967d862f6d4d434ab40da23093173e232025-02-03T06:45:28ZengWileyJournal of Diabetes Research2314-67532021-01-01202110.1155/2021/1815178The Impact of Incretin-Based Medications on Lipid MetabolismHabib Yaribeygi0Mina Maleki1Alexandra E. Butler2Tannaz Jamialahmadi3Amirhossein Sahebkar4Research Center of PhysiologyUrology and Nephrology Research CenterResearch DepartmentDepartment of Food Science and TechnologyApplied Biomedical Research CenterPathophysiological pathways that are induced by chronic hyperglycemia negatively impact lipid metabolism. Thus, diabetes is commonly accompanied by varying degrees of dyslipidemia which is itself a major risk factor for further macro- and microvascular diabetes complications such as atherosclerosis and nephropathy. Therefore, normalizing lipid metabolism is an attractive goal for therapy in patients with diabetes. Incretin-based medications are a novel group of antidiabetic agents with potent hypoglycemic effects. While the impact of incretins on glucose metabolism is clear, recent evidence indicates their positive modulatory roles on various aspects of lipid metabolism. Therefore, incretins may offer additional beneficial effects beyond that of glucose normalization. In the current review, how these antidiabetic medications can regulate lipid homeostasis and the possible cellular pathways involved are discussed, incorporating related clinical evidence about incretin effects on lipid homeostasis.http://dx.doi.org/10.1155/2021/1815178 |
| spellingShingle | Habib Yaribeygi Mina Maleki Alexandra E. Butler Tannaz Jamialahmadi Amirhossein Sahebkar The Impact of Incretin-Based Medications on Lipid Metabolism Journal of Diabetes Research |
| title | The Impact of Incretin-Based Medications on Lipid Metabolism |
| title_full | The Impact of Incretin-Based Medications on Lipid Metabolism |
| title_fullStr | The Impact of Incretin-Based Medications on Lipid Metabolism |
| title_full_unstemmed | The Impact of Incretin-Based Medications on Lipid Metabolism |
| title_short | The Impact of Incretin-Based Medications on Lipid Metabolism |
| title_sort | impact of incretin based medications on lipid metabolism |
| url | http://dx.doi.org/10.1155/2021/1815178 |
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