High Prevalence of Pfhrp2/3 Gene Deletions and Major Threat to Malaria Control Programs in Ethiopia
Conclusions: Our study provides widespread deletions in the Pfhrp2 and Pfhrp3 genes in Ethiopia, thereby confirming anecdotal reports of diagnostic failure with Pfhrp2-based RDTs in the region. The implications of our finding for the current diagnostic paradigm, which relies on the detection of P. f...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2024/8848997 |
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| _version_ | 1832546476705710080 |
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| author | Sisay Getie Gebeyaw Getnet Mekonnen Aline Lamien Meda Meseret Birhanie Aberham Abere Harald Noedl |
| author_facet | Sisay Getie Gebeyaw Getnet Mekonnen Aline Lamien Meda Meseret Birhanie Aberham Abere Harald Noedl |
| author_sort | Sisay Getie |
| collection | DOAJ |
| description | Conclusions: Our study provides widespread deletions in the Pfhrp2 and Pfhrp3 genes in Ethiopia, thereby confirming anecdotal reports of diagnostic failure with Pfhrp2-based RDTs in the region. The implications of our finding for the current diagnostic paradigm, which relies on the detection of P. falciparum by Pfhrp2-based RDTs in remote areas, may need rethinking. |
| format | Article |
| id | doaj-art-967a242479164440b14115ef4a2504ce |
| institution | Kabale University |
| issn | 1687-9694 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-967a242479164440b14115ef4a2504ce2025-02-03T06:49:44ZengWileyJournal of Tropical Medicine1687-96942024-01-01202410.1155/2024/8848997High Prevalence of Pfhrp2/3 Gene Deletions and Major Threat to Malaria Control Programs in EthiopiaSisay Getie0Gebeyaw Getnet Mekonnen1Aline Lamien Meda2Meseret Birhanie3Aberham Abere4Harald Noedl5Department of Medical Parasitology, School of Biomedical and Laboratory Science, College of Medicine and Health ScienceDepartment of Medical Parasitology, School of Biomedical and Laboratory Science, College of Medicine and Health ScienceInstitute for Specific Prophylaxis and Tropical MedicineDepartment of Medical Parasitology, School of Biomedical and Laboratory Science, College of Medicine and Health ScienceDepartment of Medical Parasitology, School of Biomedical and Laboratory Science, College of Medicine and Health ScienceInstitute for Specific Prophylaxis and Tropical MedicineConclusions: Our study provides widespread deletions in the Pfhrp2 and Pfhrp3 genes in Ethiopia, thereby confirming anecdotal reports of diagnostic failure with Pfhrp2-based RDTs in the region. The implications of our finding for the current diagnostic paradigm, which relies on the detection of P. falciparum by Pfhrp2-based RDTs in remote areas, may need rethinking.http://dx.doi.org/10.1155/2024/8848997 |
| spellingShingle | Sisay Getie Gebeyaw Getnet Mekonnen Aline Lamien Meda Meseret Birhanie Aberham Abere Harald Noedl High Prevalence of Pfhrp2/3 Gene Deletions and Major Threat to Malaria Control Programs in Ethiopia Journal of Tropical Medicine |
| title | High Prevalence of Pfhrp2/3 Gene Deletions and Major Threat to Malaria Control Programs in Ethiopia |
| title_full | High Prevalence of Pfhrp2/3 Gene Deletions and Major Threat to Malaria Control Programs in Ethiopia |
| title_fullStr | High Prevalence of Pfhrp2/3 Gene Deletions and Major Threat to Malaria Control Programs in Ethiopia |
| title_full_unstemmed | High Prevalence of Pfhrp2/3 Gene Deletions and Major Threat to Malaria Control Programs in Ethiopia |
| title_short | High Prevalence of Pfhrp2/3 Gene Deletions and Major Threat to Malaria Control Programs in Ethiopia |
| title_sort | high prevalence of pfhrp2 3 gene deletions and major threat to malaria control programs in ethiopia |
| url | http://dx.doi.org/10.1155/2024/8848997 |
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