Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications
Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in divers...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/6641128 |
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| author | Ibrahim Luru Abdulai Samuel Kojo Kwofie Winfred Seth Gbewonyo Daniel Boison Joshua Buer Puplampu Michael Buenor Adinortey |
| author_facet | Ibrahim Luru Abdulai Samuel Kojo Kwofie Winfred Seth Gbewonyo Daniel Boison Joshua Buer Puplampu Michael Buenor Adinortey |
| author_sort | Ibrahim Luru Abdulai |
| collection | DOAJ |
| description | Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research. |
| format | Article |
| id | doaj-art-9679b88724634de1983b957c812b49e7 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9679b88724634de1983b957c812b49e72025-02-03T01:24:12ZengWileyThe Scientific World Journal2356-61401537-744X2021-01-01202110.1155/2021/66411286641128Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its ComplicationsIbrahim Luru Abdulai0Samuel Kojo Kwofie1Winfred Seth Gbewonyo2Daniel Boison3Joshua Buer Puplampu4Michael Buenor Adinortey5West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, P.O. Box LG 54, Legon, Accra, GhanaWest African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, P.O. Box LG 54, Legon, Accra, GhanaDepartment of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, University of Ghana, Legon, Accra, GhanaDepartment of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Biochemistry, School of Biological Sciences, University of Cape Coast, Cape Coast, GhanaBackground. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.http://dx.doi.org/10.1155/2021/6641128 |
| spellingShingle | Ibrahim Luru Abdulai Samuel Kojo Kwofie Winfred Seth Gbewonyo Daniel Boison Joshua Buer Puplampu Michael Buenor Adinortey Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications The Scientific World Journal |
| title | Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications |
| title_full | Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications |
| title_fullStr | Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications |
| title_full_unstemmed | Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications |
| title_short | Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications |
| title_sort | multitargeted effects of vitexin and isovitexin on diabetes mellitus and its complications |
| url | http://dx.doi.org/10.1155/2021/6641128 |
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