Next-Generation Sequencing and Epigenomics Research: A Hammer in Search of Nails
After the initial enthusiasm of the human genome project, it became clear that without additional data pertaining to the epigenome, i.e., how the genome is marked at specific developmental periods, in different tissues, as well as across individuals and species-the promise of the genome sequencing p...
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BioMed Central
2014-03-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-12-2.pdf |
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| author | Shrutii Sarda Sridhar Hannenhalli |
| author_facet | Shrutii Sarda Sridhar Hannenhalli |
| author_sort | Shrutii Sarda |
| collection | DOAJ |
| description | After the initial enthusiasm of the human genome project, it became clear that without additional data pertaining to the epigenome, i.e., how the genome is marked at specific developmental periods, in different tissues, as well as across individuals and species-the promise of the genome sequencing project in understanding biology cannot be fulfilled. This realization prompted several large-scale efforts to map the epigenome, most notably the Encyclopedia of DNA Elements (ENCODE) project. While there is essentially a single genome in an individual, there are hundreds of epigenomes, corresponding to various types of epigenomic marks at different developmental times and in multiple tissue types. Unprecedented advances in next-generation sequencing (NGS) technologies, by virtue of low cost and high speeds that continue to improve at a rate beyond what is anticipated by Moore's law for computer hardware technologies, have revolutionized molecular biology and genetics research, and have in turn prompted innovative ways to reduce the problem of measuring cellular events involving DNA or RNA into a sequencing problem. In this article, we provide a brief overview of the epigenome, the various types of epigenomic data afforded by NGS, and some of the novel discoveries yielded by the epigenomics projects. We also provide ample references for the reader to get in-depth information on these topics. |
| format | Article |
| id | doaj-art-96723bfa2a5d419abfc22f3847957588 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2014-03-01 |
| publisher | BioMed Central |
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| series | Genomics & Informatics |
| spelling | doaj-art-96723bfa2a5d419abfc22f38479575882025-02-02T10:44:13ZengBioMed CentralGenomics & Informatics1598-866X2234-07422014-03-0112121110.5808/GI.2014.12.1.2106Next-Generation Sequencing and Epigenomics Research: A Hammer in Search of NailsShrutii Sarda0Sridhar Hannenhalli1Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20740, USA.Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20740, USA.After the initial enthusiasm of the human genome project, it became clear that without additional data pertaining to the epigenome, i.e., how the genome is marked at specific developmental periods, in different tissues, as well as across individuals and species-the promise of the genome sequencing project in understanding biology cannot be fulfilled. This realization prompted several large-scale efforts to map the epigenome, most notably the Encyclopedia of DNA Elements (ENCODE) project. While there is essentially a single genome in an individual, there are hundreds of epigenomes, corresponding to various types of epigenomic marks at different developmental times and in multiple tissue types. Unprecedented advances in next-generation sequencing (NGS) technologies, by virtue of low cost and high speeds that continue to improve at a rate beyond what is anticipated by Moore's law for computer hardware technologies, have revolutionized molecular biology and genetics research, and have in turn prompted innovative ways to reduce the problem of measuring cellular events involving DNA or RNA into a sequencing problem. In this article, we provide a brief overview of the epigenome, the various types of epigenomic data afforded by NGS, and some of the novel discoveries yielded by the epigenomics projects. We also provide ample references for the reader to get in-depth information on these topics.http://genominfo.org/upload/pdf/gni-12-2.pdfchromatin accessibilityepigenomicsmethylationnext-generation sequencingregulation |
| spellingShingle | Shrutii Sarda Sridhar Hannenhalli Next-Generation Sequencing and Epigenomics Research: A Hammer in Search of Nails Genomics & Informatics chromatin accessibility epigenomics methylation next-generation sequencing regulation |
| title | Next-Generation Sequencing and Epigenomics Research: A Hammer in Search of Nails |
| title_full | Next-Generation Sequencing and Epigenomics Research: A Hammer in Search of Nails |
| title_fullStr | Next-Generation Sequencing and Epigenomics Research: A Hammer in Search of Nails |
| title_full_unstemmed | Next-Generation Sequencing and Epigenomics Research: A Hammer in Search of Nails |
| title_short | Next-Generation Sequencing and Epigenomics Research: A Hammer in Search of Nails |
| title_sort | next generation sequencing and epigenomics research a hammer in search of nails |
| topic | chromatin accessibility epigenomics methylation next-generation sequencing regulation |
| url | http://genominfo.org/upload/pdf/gni-12-2.pdf |
| work_keys_str_mv | AT shrutiisarda nextgenerationsequencingandepigenomicsresearchahammerinsearchofnails AT sridharhannenhalli nextgenerationsequencingandepigenomicsresearchahammerinsearchofnails |