Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications
Magnetic nanoparticles (MNPs) made of iron oxides with cubic symmetry (Fe3O4, γ-Fe2O3) are demanded objects for multipurpose in biomedical applications as contrast agents for magnetic resonance imaging, magnetically driven carriers for drug delivery, and heaters in hyperthermia cancer treatment. An...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2018/1412563 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554680552521728 |
|---|---|
| author | A. P. Budnyk T. A. Lastovina A. L. Bugaev V. A. Polyakov K. S. Vetlitsyna-Novikova M. A. Sirota K. G. Abdulvakhidov A. G. Fedorenko E. O. Podlesnaya A. V. Soldatov |
| author_facet | A. P. Budnyk T. A. Lastovina A. L. Bugaev V. A. Polyakov K. S. Vetlitsyna-Novikova M. A. Sirota K. G. Abdulvakhidov A. G. Fedorenko E. O. Podlesnaya A. V. Soldatov |
| author_sort | A. P. Budnyk |
| collection | DOAJ |
| description | Magnetic nanoparticles (MNPs) made of iron oxides with cubic symmetry (Fe3O4, γ-Fe2O3) are demanded objects for multipurpose in biomedical applications as contrast agents for magnetic resonance imaging, magnetically driven carriers for drug delivery, and heaters in hyperthermia cancer treatment. An optimum balance between the right particle size and good magnetic response can be reached by a selection of a synthesis method and by doping with rare earth elements. Here, we present a microwave-assisted polyol synthesis of iron oxide MNPs with actual gadolinium (III) doping from 0.5 to 5.1 mol.%. The resulting MNPs have an average size of 14 nm with narrow size distribution. Their surface was covered by a glycol layer, which prevents aggregation and improves biocompatibility. The magnetic hyperthermia test was performed on 1 and 2 mg/ml aqueous colloidal solutions of MNPs and demonstrated their ability to rise the temperature by 3°C during a 20–30 min run. Therefore, the obtained Gd3+ MNPs are the promising material for biomedicine. |
| format | Article |
| id | doaj-art-966a3a9b594a47be981f6a1abb800612 |
| institution | Kabale University |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-966a3a9b594a47be981f6a1abb8006122025-02-03T05:50:51ZengWileyJournal of Spectroscopy2314-49202314-49392018-01-01201810.1155/2018/14125631412563Gd3+-Doped Magnetic Nanoparticles for Biomedical ApplicationsA. P. Budnyk0T. A. Lastovina1A. L. Bugaev2V. A. Polyakov3K. S. Vetlitsyna-Novikova4M. A. Sirota5K. G. Abdulvakhidov6A. G. Fedorenko7E. O. Podlesnaya8A. V. Soldatov9The Smart Materials Research Center, Southern Federal University, 344090 Rostov-on-Don, RussiaThe Smart Materials Research Center, Southern Federal University, 344090 Rostov-on-Don, RussiaThe Smart Materials Research Center, Southern Federal University, 344090 Rostov-on-Don, RussiaThe Smart Materials Research Center, Southern Federal University, 344090 Rostov-on-Don, RussiaThe Smart Materials Research Center, Southern Federal University, 344090 Rostov-on-Don, RussiaDon State Technical University, 344010 Rostov-on-Don, RussiaThe Smart Materials Research Center, Southern Federal University, 344090 Rostov-on-Don, RussiaModern Microscopy Center, Academy of Biology and Biotechnology, Southern Federal University, 344090 Rostov-on-Don, RussiaDepartment of Chemistry, Southern Federal University, 344090 Rostov-on-Don, RussiaThe Smart Materials Research Center, Southern Federal University, 344090 Rostov-on-Don, RussiaMagnetic nanoparticles (MNPs) made of iron oxides with cubic symmetry (Fe3O4, γ-Fe2O3) are demanded objects for multipurpose in biomedical applications as contrast agents for magnetic resonance imaging, magnetically driven carriers for drug delivery, and heaters in hyperthermia cancer treatment. An optimum balance between the right particle size and good magnetic response can be reached by a selection of a synthesis method and by doping with rare earth elements. Here, we present a microwave-assisted polyol synthesis of iron oxide MNPs with actual gadolinium (III) doping from 0.5 to 5.1 mol.%. The resulting MNPs have an average size of 14 nm with narrow size distribution. Their surface was covered by a glycol layer, which prevents aggregation and improves biocompatibility. The magnetic hyperthermia test was performed on 1 and 2 mg/ml aqueous colloidal solutions of MNPs and demonstrated their ability to rise the temperature by 3°C during a 20–30 min run. Therefore, the obtained Gd3+ MNPs are the promising material for biomedicine.http://dx.doi.org/10.1155/2018/1412563 |
| spellingShingle | A. P. Budnyk T. A. Lastovina A. L. Bugaev V. A. Polyakov K. S. Vetlitsyna-Novikova M. A. Sirota K. G. Abdulvakhidov A. G. Fedorenko E. O. Podlesnaya A. V. Soldatov Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications Journal of Spectroscopy |
| title | Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications |
| title_full | Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications |
| title_fullStr | Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications |
| title_full_unstemmed | Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications |
| title_short | Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications |
| title_sort | gd3 doped magnetic nanoparticles for biomedical applications |
| url | http://dx.doi.org/10.1155/2018/1412563 |
| work_keys_str_mv | AT apbudnyk gd3dopedmagneticnanoparticlesforbiomedicalapplications AT talastovina gd3dopedmagneticnanoparticlesforbiomedicalapplications AT albugaev gd3dopedmagneticnanoparticlesforbiomedicalapplications AT vapolyakov gd3dopedmagneticnanoparticlesforbiomedicalapplications AT ksvetlitsynanovikova gd3dopedmagneticnanoparticlesforbiomedicalapplications AT masirota gd3dopedmagneticnanoparticlesforbiomedicalapplications AT kgabdulvakhidov gd3dopedmagneticnanoparticlesforbiomedicalapplications AT agfedorenko gd3dopedmagneticnanoparticlesforbiomedicalapplications AT eopodlesnaya gd3dopedmagneticnanoparticlesforbiomedicalapplications AT avsoldatov gd3dopedmagneticnanoparticlesforbiomedicalapplications |