Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein
Olopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H1 receptor antagonistic activity. Recently, olopatadine has been shown to bind to S100A12 which is a member of the S100 family of calcium-binding proteins, and exerts multiple proinflammatory activities including chemota...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/42726 |
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| author | Kazuya Kishimoto Satoshi Kaneko Kenji Ohmori Tadafumi Tamura Kazuhide Hasegawa |
| author_facet | Kazuya Kishimoto Satoshi Kaneko Kenji Ohmori Tadafumi Tamura Kazuhide Hasegawa |
| author_sort | Kazuya Kishimoto |
| collection | DOAJ |
| description | Olopatadine hydrochloride (olopatadine) is an antiallergic drug
with histamine H1 receptor antagonistic activity.
Recently, olopatadine has been shown to bind to S100A12 which is a
member of the S100 family of calcium-binding proteins, and exerts
multiple proinflammatory activities including chemotaxis
for monocytes and neutrophils. In this study, we examined the
possibility that the interaction of olopatadine with S100A12
inhibits the proinflammatory effects of S100A12. Pretreatment of
olopatadine with S100A12 reduced migration of THP-1, a monocyte
cell line, induced by S100A12 alone, but did not affect
recombinant human regulated upon activation, normal T cell
expressed and secreted (RANTES)-induced migration. Amlexanox,
which also binds to S100A12, inhibited the THP-1 migration induced
by S100A12. However, ketotifen, another histamine H1 receptor antagonist, had little effect on the activity of S100A12.
These results suggest that olopatadine has a new mechanism of
action, that is, suppression of the function of S100A12, in
addition to histamine H1 receptor antagonistic activity. |
| format | Article |
| id | doaj-art-966632ed7c994bb0a970b11d4b1a9408 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-966632ed7c994bb0a970b11d4b1a94082025-02-03T06:11:15ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/4272642726Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 ProteinKazuya Kishimoto0Satoshi Kaneko1Kenji Ohmori2Tadafumi Tamura3Kazuhide Hasegawa4Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, JapanPharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, JapanPharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, JapanPharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, JapanPharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8731, JapanOlopatadine hydrochloride (olopatadine) is an antiallergic drug with histamine H1 receptor antagonistic activity. Recently, olopatadine has been shown to bind to S100A12 which is a member of the S100 family of calcium-binding proteins, and exerts multiple proinflammatory activities including chemotaxis for monocytes and neutrophils. In this study, we examined the possibility that the interaction of olopatadine with S100A12 inhibits the proinflammatory effects of S100A12. Pretreatment of olopatadine with S100A12 reduced migration of THP-1, a monocyte cell line, induced by S100A12 alone, but did not affect recombinant human regulated upon activation, normal T cell expressed and secreted (RANTES)-induced migration. Amlexanox, which also binds to S100A12, inhibited the THP-1 migration induced by S100A12. However, ketotifen, another histamine H1 receptor antagonist, had little effect on the activity of S100A12. These results suggest that olopatadine has a new mechanism of action, that is, suppression of the function of S100A12, in addition to histamine H1 receptor antagonistic activity.http://dx.doi.org/10.1155/MI/2006/42726 |
| spellingShingle | Kazuya Kishimoto Satoshi Kaneko Kenji Ohmori Tadafumi Tamura Kazuhide Hasegawa Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein Mediators of Inflammation |
| title | Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein |
| title_full | Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein |
| title_fullStr | Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein |
| title_full_unstemmed | Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein |
| title_short | Olopatadine Suppresses the Migration of THP-1 Monocytes Induced by S100A12 Protein |
| title_sort | olopatadine suppresses the migration of thp 1 monocytes induced by s100a12 protein |
| url | http://dx.doi.org/10.1155/MI/2006/42726 |
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