Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States
Abstract Racial/ethnic differences are associated with the symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These differences may exist among children and warrant further exploration. We conducted a retrospective cohort study with difference-in-differences analyz...
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Nature Portfolio
2025-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-55273-z |
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| author | Dazheng Zhang Bingyu Zhang Qiong Wu Ting Zhou Jiayi Tong Yiwen Lu Jiajie Chen Huiyuan Wang Deena J. Chisolm Ravi Jhaveri Rachel C. Kenney Russell L. Rothman Suchitra Rao David A. Williams Mady Hornig Linbo Wang Jeffrey S. Morris Christopher B. Forrest Yong Chen |
| author_facet | Dazheng Zhang Bingyu Zhang Qiong Wu Ting Zhou Jiayi Tong Yiwen Lu Jiajie Chen Huiyuan Wang Deena J. Chisolm Ravi Jhaveri Rachel C. Kenney Russell L. Rothman Suchitra Rao David A. Williams Mady Hornig Linbo Wang Jeffrey S. Morris Christopher B. Forrest Yong Chen |
| author_sort | Dazheng Zhang |
| collection | DOAJ |
| description | Abstract Racial/ethnic differences are associated with the symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These differences may exist among children and warrant further exploration. We conducted a retrospective cohort study with difference-in-differences analyzes to assess these differences in children and adolescents under the age of 21. The study utilized data from the RECOVER Initiative in the United States, which aims to learn about the long-term effects of COVID-19. The cohort included 225,723 patients with SARS-CoV-2 infection or COVID-19 diagnosis between March 2020 and October 2022. The study compared minority racial/ethnic groups to Non-Hispanic White (NHW) individuals, stratified by severity during the acute phase of COVID-19. Within the severe group, Asian American/Pacific Islanders (AAPI) had a higher prevalence of fever/chills and respiratory signs and symptoms, Hispanic patients showed greater hair loss prevalence in severe COVID-19 cases, while Non-Hispanic Black (NHB) patients had fewer skin symptoms in comparison to NHW patients. Within the non-severe group, AAPI patients had increased POTS/dysautonomia and respiratory symptoms, and NHB patients showed more cognitive symptoms than NHW patients. In conclusion, racial/ethnic differences related to COVID-19 exist among PASC symptoms and conditions in pediatrics, and these differences are associated with the severity of illness during acute COVID-19. |
| format | Article |
| id | doaj-art-9659baa9657f46e08ece0857bbbbe3fe |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-9659baa9657f46e08ece0857bbbbe3fe2025-01-26T12:41:15ZengNature PortfolioNature Communications2041-17232025-01-0116111110.1038/s41467-024-55273-zRacial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United StatesDazheng Zhang0Bingyu Zhang1Qiong Wu2Ting Zhou3Jiayi Tong4Yiwen Lu5Jiajie Chen6Huiyuan Wang7Deena J. Chisolm8Ravi Jhaveri9Rachel C. Kenney10Russell L. Rothman11Suchitra Rao12David A. Williams13Mady Hornig14Linbo Wang15Jeffrey S. Morris16Christopher B. Forrest17Yong Chen18The Center for Health AI and Synthesis of Evidence (CHASE), University of PennsylvaniaThe Center for Health AI and Synthesis of Evidence (CHASE), University of PennsylvaniaThe Center for Health AI and Synthesis of Evidence (CHASE), University of PennsylvaniaThe Center for Health AI and Synthesis of Evidence (CHASE), University of PennsylvaniaThe Center for Health AI and Synthesis of Evidence (CHASE), University of PennsylvaniaThe Center for Health AI and Synthesis of Evidence (CHASE), University of PennsylvaniaThe Center for Health AI and Synthesis of Evidence (CHASE), University of PennsylvaniaThe Center for Health AI and Synthesis of Evidence (CHASE), University of PennsylvaniaAbigail Wexner Research Institute Nationwide Children’s HospitalDivision of Infectious Diseases, Ann & Robert H. Lurie Children’s Hospital of ChicagoDepartment of Neurology, New York University Grossman School of MedicineVanderbilt Institute for Medicine and Public Health, Vanderbilt University Medical CenterDepartment of Pediatrics, University of Colorado School of Medicine and Children’s Hospital ColoradoDepartment of Anesthesiology, University of MichiganDepartment of Epidemiology, Columbia University Mailman School of Public HealthDepartment of Statistical Sciences, University of TorontoDepartment of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of PennsylvaniaApplied Clinical Research Center, Children’s Hospital of PhiladelphiaThe Center for Health AI and Synthesis of Evidence (CHASE), University of PennsylvaniaAbstract Racial/ethnic differences are associated with the symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These differences may exist among children and warrant further exploration. We conducted a retrospective cohort study with difference-in-differences analyzes to assess these differences in children and adolescents under the age of 21. The study utilized data from the RECOVER Initiative in the United States, which aims to learn about the long-term effects of COVID-19. The cohort included 225,723 patients with SARS-CoV-2 infection or COVID-19 diagnosis between March 2020 and October 2022. The study compared minority racial/ethnic groups to Non-Hispanic White (NHW) individuals, stratified by severity during the acute phase of COVID-19. Within the severe group, Asian American/Pacific Islanders (AAPI) had a higher prevalence of fever/chills and respiratory signs and symptoms, Hispanic patients showed greater hair loss prevalence in severe COVID-19 cases, while Non-Hispanic Black (NHB) patients had fewer skin symptoms in comparison to NHW patients. Within the non-severe group, AAPI patients had increased POTS/dysautonomia and respiratory symptoms, and NHB patients showed more cognitive symptoms than NHW patients. In conclusion, racial/ethnic differences related to COVID-19 exist among PASC symptoms and conditions in pediatrics, and these differences are associated with the severity of illness during acute COVID-19.https://doi.org/10.1038/s41467-024-55273-z |
| spellingShingle | Dazheng Zhang Bingyu Zhang Qiong Wu Ting Zhou Jiayi Tong Yiwen Lu Jiajie Chen Huiyuan Wang Deena J. Chisolm Ravi Jhaveri Rachel C. Kenney Russell L. Rothman Suchitra Rao David A. Williams Mady Hornig Linbo Wang Jeffrey S. Morris Christopher B. Forrest Yong Chen Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States Nature Communications |
| title | Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States |
| title_full | Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States |
| title_fullStr | Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States |
| title_full_unstemmed | Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States |
| title_short | Racial/ethnic differences in post-acute sequelae of SARS-CoV-2 in children and adolescents in the United States |
| title_sort | racial ethnic differences in post acute sequelae of sars cov 2 in children and adolescents in the united states |
| url | https://doi.org/10.1038/s41467-024-55273-z |
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