Metabolic plasticity in pancreatic cancer: The mitochondrial connection
Background: Cellular metabolism plays a pivotal role in the development and progression of pancreatic ductal adenocarcinoma (PDAC), with dysregulated metabolic pathways contributing to tumorigenesis and therapeutic resistance. Distinct metabolic heterogeneity in pancreatic cancer significantly impac...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Molecular Metabolism |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877824002205 |
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| author | Noemi Ghiglione Damiano Abbo Anastasia Bushunova Andrea Costamagna Paolo Ettore Porporato Miriam Martini |
| author_facet | Noemi Ghiglione Damiano Abbo Anastasia Bushunova Andrea Costamagna Paolo Ettore Porporato Miriam Martini |
| author_sort | Noemi Ghiglione |
| collection | DOAJ |
| description | Background: Cellular metabolism plays a pivotal role in the development and progression of pancreatic ductal adenocarcinoma (PDAC), with dysregulated metabolic pathways contributing to tumorigenesis and therapeutic resistance. Distinct metabolic heterogeneity in pancreatic cancer significantly impacts patient prognosis, as variations in metabolic profiles influence tumor behavior and treatment responses.Scope of the Review: This review explores the intricate interplay between mitochondrial dynamics, mitophagy, and cellular metabolism in PDAC. We discuss the significance of mitophagy dysregulation in PDAC pathogenesis, emphasizing its influence on treatment responses and prognosis. Furthermore, we analyze the impact of mitochondrial dynamics alterations, including fission and fusion processes, on PDAC progression and tumorigenesis. Major Conclusion: Targeting mitochondrial metabolism holds promise for advancing PDAC therapeutics. Ongoing clinical trials underscore the therapeutic potential of modulating key regulators of mitochondrial dynamics and mitophagy. Despite inherent challenges, these approaches offer diverse strategies to enhance treatment efficacy and improve patient outcomes. |
| format | Article |
| id | doaj-art-9653a8ab11e24fccaf1c9ecb8aaea6cd |
| institution | Kabale University |
| issn | 2212-8778 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Metabolism |
| spelling | doaj-art-9653a8ab11e24fccaf1c9ecb8aaea6cd2025-02-01T04:11:57ZengElsevierMolecular Metabolism2212-87782025-02-0192102089Metabolic plasticity in pancreatic cancer: The mitochondrial connectionNoemi Ghiglione0Damiano Abbo1Anastasia Bushunova2Andrea Costamagna3Paolo Ettore Porporato4Miriam Martini5Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC) Guido Tarone, University of Turin, Torino, ItalyDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC) Guido Tarone, University of Turin, Torino, ItalyDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC) Guido Tarone, University of Turin, Torino, ItalyDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC) Guido Tarone, University of Turin, Torino, ItalyDepartment of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC) Guido Tarone, University of Turin, Torino, ItalyCorresponding author.; Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center (MBC) Guido Tarone, University of Turin, Torino, ItalyBackground: Cellular metabolism plays a pivotal role in the development and progression of pancreatic ductal adenocarcinoma (PDAC), with dysregulated metabolic pathways contributing to tumorigenesis and therapeutic resistance. Distinct metabolic heterogeneity in pancreatic cancer significantly impacts patient prognosis, as variations in metabolic profiles influence tumor behavior and treatment responses.Scope of the Review: This review explores the intricate interplay between mitochondrial dynamics, mitophagy, and cellular metabolism in PDAC. We discuss the significance of mitophagy dysregulation in PDAC pathogenesis, emphasizing its influence on treatment responses and prognosis. Furthermore, we analyze the impact of mitochondrial dynamics alterations, including fission and fusion processes, on PDAC progression and tumorigenesis. Major Conclusion: Targeting mitochondrial metabolism holds promise for advancing PDAC therapeutics. Ongoing clinical trials underscore the therapeutic potential of modulating key regulators of mitochondrial dynamics and mitophagy. Despite inherent challenges, these approaches offer diverse strategies to enhance treatment efficacy and improve patient outcomes.http://www.sciencedirect.com/science/article/pii/S2212877824002205Pancreatic cancerMitochondriaMetabolismOxidative phosphorylationMitophagy |
| spellingShingle | Noemi Ghiglione Damiano Abbo Anastasia Bushunova Andrea Costamagna Paolo Ettore Porporato Miriam Martini Metabolic plasticity in pancreatic cancer: The mitochondrial connection Molecular Metabolism Pancreatic cancer Mitochondria Metabolism Oxidative phosphorylation Mitophagy |
| title | Metabolic plasticity in pancreatic cancer: The mitochondrial connection |
| title_full | Metabolic plasticity in pancreatic cancer: The mitochondrial connection |
| title_fullStr | Metabolic plasticity in pancreatic cancer: The mitochondrial connection |
| title_full_unstemmed | Metabolic plasticity in pancreatic cancer: The mitochondrial connection |
| title_short | Metabolic plasticity in pancreatic cancer: The mitochondrial connection |
| title_sort | metabolic plasticity in pancreatic cancer the mitochondrial connection |
| topic | Pancreatic cancer Mitochondria Metabolism Oxidative phosphorylation Mitophagy |
| url | http://www.sciencedirect.com/science/article/pii/S2212877824002205 |
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