Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring
The impact of micro/nano plastics (MPs/NPs) on human health is a significant area of research. Studies on the effects of maternal exposure to microplastics (MPs) on the fertility in offspring have been conducted, but the damage caused by nanoplastics (NPs) remains ambiguous. In this study, pregnant...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324017081 |
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| author | Xiu Cheng Yue Xue Houpeng Wang Zhangqiang Ma Na Hu Chenchen Zhang Yu Gao Ruihong Fan Liaoliao Hu Jia Li Dalei Zhang Jian Huang Sitian Fang Runting Xiao Yuanqiao He Tao Luo Liping Zheng |
| author_facet | Xiu Cheng Yue Xue Houpeng Wang Zhangqiang Ma Na Hu Chenchen Zhang Yu Gao Ruihong Fan Liaoliao Hu Jia Li Dalei Zhang Jian Huang Sitian Fang Runting Xiao Yuanqiao He Tao Luo Liping Zheng |
| author_sort | Xiu Cheng |
| collection | DOAJ |
| description | The impact of micro/nano plastics (MPs/NPs) on human health is a significant area of research. Studies on the effects of maternal exposure to microplastics (MPs) on the fertility in offspring have been conducted, but the damage caused by nanoplastics (NPs) remains ambiguous. In this study, pregnant Kunming mice were exposed to 30 mg/kg/day PS-NPs from 0.5 gestation day (GD) to 21 days postpartum (dpp). Increased rates of miscarriage and premature delivery were observed, as well as reduced litter size, indicating potential permanent reproductive injury in mice of PS-NPs group. Maternal exposure to PS-NPs impaired fertility of the female offsprings. Decreased primordial and increased growing follicles were observed in the ovaries of offspring at 1 dpp and 7 dpp in PS-NPs group, indicating premature activation of primordial follicles. This premature activation is likely due to the PS-NPs'induction of the AKT-FOXO3a signaling pathway by downregulating AMPK phosphorylation level and enhancing mTOR activity. Furthermore, a significant reduction in transzonal projections (TZPs) was noted in the ovaries of adult offspring mice in PS-NPs group. RNA sequencing of the ovaries from adult offspring female mice revealed that the TZPs related genes may be linked to CAMKIIβ, with a corresponding downregulation in expression levels. Overall, maternal exposure to PS-NPs induced profound and enduring effects on the reproductive functions of female offspring, raising critical alarms regarding the multigenerational reproductive toxicity risks associated with nanoplastic exposure in mammals. |
| format | Article |
| id | doaj-art-9641de42106c4fa99a82235c69340b6f |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-9641de42106c4fa99a82235c69340b6f2025-01-23T05:25:55ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117632Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspringXiu Cheng0Yue Xue1Houpeng Wang2Zhangqiang Ma3Na Hu4Chenchen Zhang5Yu Gao6Ruihong Fan7Liaoliao Hu8Jia Li9Dalei Zhang10Jian Huang11Sitian Fang12Runting Xiao13Yuanqiao He14Tao Luo15Liping Zheng16School of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, ChinaSchool of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, China; Department of Reproductive Medicine, the 1st affiliated hospital, Jiangxi Medical College, Nanchang University; Jiangxi Key Laboratory of Reproductive Health, Nanchang 330006, ChinaSchool of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, ChinaSchool of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, ChinaSchool of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, ChinaSchool of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, ChinaSchool of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, ChinaSchool of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, ChinaThe 2nd affiliated hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang 330031, ChinaSchool of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, ChinaClinical Medical Experimental Center, Jiangxi Medical College, Nanchang University, ChinaHuanKui College, Nanchang University, Nanchang 330031, ChinaHuanKui College, Nanchang University, Nanchang 330031, ChinaCenter of Laboratory Animal Science, Nanchang University, No.999, Xuefu Road, Nanchang 330031, China; Nanchang Royo Biotech Co,. Ltd, ChinaSchool of Basic Medical Sciences, Jiangxi Medical College, Nanchang University; Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang 330031, ChinaSchool of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, China; Department of Reproductive Medicine, the 1st affiliated hospital, Jiangxi Medical College, Nanchang University; Jiangxi Key Laboratory of Reproductive Health, Nanchang 330006, China; HuanKui College, Nanchang University, Nanchang 330031, China; Chongqing Research Institute of Nanchang University, Nanchang University, Nanchang 330006, China; Corresponding author at: School of Public Health, Jiangxi Medical College, Nanchang University; Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, ChinaThe impact of micro/nano plastics (MPs/NPs) on human health is a significant area of research. Studies on the effects of maternal exposure to microplastics (MPs) on the fertility in offspring have been conducted, but the damage caused by nanoplastics (NPs) remains ambiguous. In this study, pregnant Kunming mice were exposed to 30 mg/kg/day PS-NPs from 0.5 gestation day (GD) to 21 days postpartum (dpp). Increased rates of miscarriage and premature delivery were observed, as well as reduced litter size, indicating potential permanent reproductive injury in mice of PS-NPs group. Maternal exposure to PS-NPs impaired fertility of the female offsprings. Decreased primordial and increased growing follicles were observed in the ovaries of offspring at 1 dpp and 7 dpp in PS-NPs group, indicating premature activation of primordial follicles. This premature activation is likely due to the PS-NPs'induction of the AKT-FOXO3a signaling pathway by downregulating AMPK phosphorylation level and enhancing mTOR activity. Furthermore, a significant reduction in transzonal projections (TZPs) was noted in the ovaries of adult offspring mice in PS-NPs group. RNA sequencing of the ovaries from adult offspring female mice revealed that the TZPs related genes may be linked to CAMKIIβ, with a corresponding downregulation in expression levels. Overall, maternal exposure to PS-NPs induced profound and enduring effects on the reproductive functions of female offspring, raising critical alarms regarding the multigenerational reproductive toxicity risks associated with nanoplastic exposure in mammals.http://www.sciencedirect.com/science/article/pii/S0147651324017081Polystyrene nanoplasticsPrimordial folliclesMaternal exposureReproductive damageProgeny |
| spellingShingle | Xiu Cheng Yue Xue Houpeng Wang Zhangqiang Ma Na Hu Chenchen Zhang Yu Gao Ruihong Fan Liaoliao Hu Jia Li Dalei Zhang Jian Huang Sitian Fang Runting Xiao Yuanqiao He Tao Luo Liping Zheng Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring Ecotoxicology and Environmental Safety Polystyrene nanoplastics Primordial follicles Maternal exposure Reproductive damage Progeny |
| title | Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring |
| title_full | Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring |
| title_fullStr | Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring |
| title_full_unstemmed | Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring |
| title_short | Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring |
| title_sort | maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring |
| topic | Polystyrene nanoplastics Primordial follicles Maternal exposure Reproductive damage Progeny |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324017081 |
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