Greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of organizing solution
Daptomycin (DPT) is a lipopeptide antibiotic used primarily to treat severe infections caused by Gram-positive bacteria. A spectrofluorimetric detection of DPT using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of an organizing solution is presented in this study...
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624006441 |
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| author | Maha F. El-Tohamy Amal M. Al-Mohaimeed Haitham AlRabiah Gamal A.E. Mostafa |
| author_facet | Maha F. El-Tohamy Amal M. Al-Mohaimeed Haitham AlRabiah Gamal A.E. Mostafa |
| author_sort | Maha F. El-Tohamy |
| collection | DOAJ |
| description | Daptomycin (DPT) is a lipopeptide antibiotic used primarily to treat severe infections caused by Gram-positive bacteria. A spectrofluorimetric detection of DPT using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of an organizing solution is presented in this study. The study describes a unique analytical method for detecting daptomycin (DPT) in pharmaceutical formulations, which employs a novel fluorescent system based on zinc oxide nanoparticles (ZnO-NPs) and cetylpyridinium chloride (CPC). The ZnO-NPs were produced using an environmentally friendly technique that included Commiphora myrrha extract, which serves as both a reducing and stabilizing agent in the green synthesis process. The morphology, size, and structural properties of the ZnO-NPs were carefully investigated utilizing a variety of spectroscopic and microscopic methods. The new method makes use of the unique fluorescence capabilities of ZnO-NPs in the presence of CPC for the highly sensitive and selective detection of DPT. This method facilitates precise quantification over a wide calibration range of 0.05–10 µg/mL, exhibiting remarkable sensitivity. The method is highly accurate, with DPT recoveries typically surpassing 99 %, indicating its reliability. Intermediate precision was utilized to evaluate both accuracy and precision in accordance with methodological requirements. The greenness of the method assessment emphasizes its ecologically friendly approach, which uses Commiphora myrrha extract for the sustainable synthesis of ZnO-NPs, minimizing environmental effects while maintaining strong analytical performance. |
| format | Article |
| id | doaj-art-96365fc2c9cd4366bf0a039ca95db07d |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-96365fc2c9cd4366bf0a039ca95db07d2025-01-29T05:00:39ZengElsevierResults in Chemistry2211-71562025-01-0113101948Greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of organizing solutionMaha F. El-Tohamy0Amal M. Al-Mohaimeed1Haitham AlRabiah2Gamal A.E. Mostafa3Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia; Corresponding author.Daptomycin (DPT) is a lipopeptide antibiotic used primarily to treat severe infections caused by Gram-positive bacteria. A spectrofluorimetric detection of DPT using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of an organizing solution is presented in this study. The study describes a unique analytical method for detecting daptomycin (DPT) in pharmaceutical formulations, which employs a novel fluorescent system based on zinc oxide nanoparticles (ZnO-NPs) and cetylpyridinium chloride (CPC). The ZnO-NPs were produced using an environmentally friendly technique that included Commiphora myrrha extract, which serves as both a reducing and stabilizing agent in the green synthesis process. The morphology, size, and structural properties of the ZnO-NPs were carefully investigated utilizing a variety of spectroscopic and microscopic methods. The new method makes use of the unique fluorescence capabilities of ZnO-NPs in the presence of CPC for the highly sensitive and selective detection of DPT. This method facilitates precise quantification over a wide calibration range of 0.05–10 µg/mL, exhibiting remarkable sensitivity. The method is highly accurate, with DPT recoveries typically surpassing 99 %, indicating its reliability. Intermediate precision was utilized to evaluate both accuracy and precision in accordance with methodological requirements. The greenness of the method assessment emphasizes its ecologically friendly approach, which uses Commiphora myrrha extract for the sustainable synthesis of ZnO-NPs, minimizing environmental effects while maintaining strong analytical performance.http://www.sciencedirect.com/science/article/pii/S2211715624006441DaptomycinNanosensorsMetal oxidesCommiphora myrrhaFluorescence detectionGreenness studies |
| spellingShingle | Maha F. El-Tohamy Amal M. Al-Mohaimeed Haitham AlRabiah Gamal A.E. Mostafa Greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of organizing solution Results in Chemistry Daptomycin Nanosensors Metal oxides Commiphora myrrha Fluorescence detection Greenness studies |
| title | Greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of organizing solution |
| title_full | Greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of organizing solution |
| title_fullStr | Greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of organizing solution |
| title_full_unstemmed | Greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of organizing solution |
| title_short | Greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of organizing solution |
| title_sort | greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via commiphora myrrha extract in the presence of organizing solution |
| topic | Daptomycin Nanosensors Metal oxides Commiphora myrrha Fluorescence detection Greenness studies |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624006441 |
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