The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice
Serum creatinine levels are the most used clinical marker to estimate renal function as the glomerular function rate because it is simple, fast, and inexpensive. However, creatinine has limitations, as its levels can be influenced by factors such as advanced age, physical activity, protein-rich diet...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/1/41 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588918096134144 |
|---|---|
| author | Marcela Ávila Mariana G. Mora Sánchez Alma Sofía Bernal Amador Ramón Paniagua |
| author_facet | Marcela Ávila Mariana G. Mora Sánchez Alma Sofía Bernal Amador Ramón Paniagua |
| author_sort | Marcela Ávila |
| collection | DOAJ |
| description | Serum creatinine levels are the most used clinical marker to estimate renal function as the glomerular function rate because it is simple, fast, and inexpensive. However, creatinine has limitations, as its levels can be influenced by factors such as advanced age, physical activity, protein-rich diets, male gender, medications, and ethnicity. Serum cystatin C and its combination with serum creatinine may serve as an alternative since these factors do not affect it. Most creatinine synthesis occurs in the muscles, making it a valuable marker for assessing lean body mass within body composition. This measurement is crucial for evaluating and monitoring nutritional status in patients with chronic kidney disease. This review aimed to discuss the literature on creatinine metabolism, its advantages and disadvantages in assessing renal function, and its utility in measuring lean body mass. The variability in the creatinine generation rate among individuals should be considered when assessing the glomerular function rate. |
| format | Article |
| id | doaj-art-9635409ea20c4dde909c26baa0c28253 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-9635409ea20c4dde909c26baa0c282532025-01-24T13:24:58ZengMDPI AGBiomolecules2218-273X2025-01-011514110.3390/biom15010041The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical PracticeMarcela Ávila0Mariana G. Mora Sánchez1Alma Sofía Bernal Amador2Ramón Paniagua3Unidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro Social, Ciudad de México 06720, MexicoUnidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro Social, Ciudad de México 06720, MexicoUnidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro Social, Ciudad de México 06720, MexicoUnidad de Investigación Médica en Enfermedades Nefrológicas, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro Social, Ciudad de México 06720, MexicoSerum creatinine levels are the most used clinical marker to estimate renal function as the glomerular function rate because it is simple, fast, and inexpensive. However, creatinine has limitations, as its levels can be influenced by factors such as advanced age, physical activity, protein-rich diets, male gender, medications, and ethnicity. Serum cystatin C and its combination with serum creatinine may serve as an alternative since these factors do not affect it. Most creatinine synthesis occurs in the muscles, making it a valuable marker for assessing lean body mass within body composition. This measurement is crucial for evaluating and monitoring nutritional status in patients with chronic kidney disease. This review aimed to discuss the literature on creatinine metabolism, its advantages and disadvantages in assessing renal function, and its utility in measuring lean body mass. The variability in the creatinine generation rate among individuals should be considered when assessing the glomerular function rate.https://www.mdpi.com/2218-273X/15/1/41creatinine metabolismglomerular filtration ratemuscle mass markerscystatin Cchronic kidney diseasecreatinine kinetics |
| spellingShingle | Marcela Ávila Mariana G. Mora Sánchez Alma Sofía Bernal Amador Ramón Paniagua The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice Biomolecules creatinine metabolism glomerular filtration rate muscle mass markers cystatin C chronic kidney disease creatinine kinetics |
| title | The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice |
| title_full | The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice |
| title_fullStr | The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice |
| title_full_unstemmed | The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice |
| title_short | The Metabolism of Creatinine and Its Usefulness to Evaluate Kidney Function and Body Composition in Clinical Practice |
| title_sort | metabolism of creatinine and its usefulness to evaluate kidney function and body composition in clinical practice |
| topic | creatinine metabolism glomerular filtration rate muscle mass markers cystatin C chronic kidney disease creatinine kinetics |
| url | https://www.mdpi.com/2218-273X/15/1/41 |
| work_keys_str_mv | AT marcelaavila themetabolismofcreatinineanditsusefulnesstoevaluatekidneyfunctionandbodycompositioninclinicalpractice AT marianagmorasanchez themetabolismofcreatinineanditsusefulnesstoevaluatekidneyfunctionandbodycompositioninclinicalpractice AT almasofiabernalamador themetabolismofcreatinineanditsusefulnesstoevaluatekidneyfunctionandbodycompositioninclinicalpractice AT ramonpaniagua themetabolismofcreatinineanditsusefulnesstoevaluatekidneyfunctionandbodycompositioninclinicalpractice AT marcelaavila metabolismofcreatinineanditsusefulnesstoevaluatekidneyfunctionandbodycompositioninclinicalpractice AT marianagmorasanchez metabolismofcreatinineanditsusefulnesstoevaluatekidneyfunctionandbodycompositioninclinicalpractice AT almasofiabernalamador metabolismofcreatinineanditsusefulnesstoevaluatekidneyfunctionandbodycompositioninclinicalpractice AT ramonpaniagua metabolismofcreatinineanditsusefulnesstoevaluatekidneyfunctionandbodycompositioninclinicalpractice |