Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión Sistemática
Background: Von Hippel-Lindau disease is an autosomal dominant syndrome characterized by the development of benign and malignant tumors throughout life. For many years, neoplasms associated with this disease were treated by surgical resection or ablation with the aim of reducing the risk of metasta...
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| Format: | Article |
| Language: | Spanish |
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Sociedad de Lucha contra el Cáncer-SOLCA
2025-01-01
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| Series: | Oncología |
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| Online Access: | https://roe.solca.med.ec/index.php/johs/article/view/765 |
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| author | Veronica Hurtado Hurtado Cristina Cabrera Mañay Patricia Tamayo Aguilar |
| author_facet | Veronica Hurtado Hurtado Cristina Cabrera Mañay Patricia Tamayo Aguilar |
| author_sort | Veronica Hurtado Hurtado |
| collection | DOAJ |
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Background: Von Hippel-Lindau disease is an autosomal dominant syndrome characterized by the development of benign and malignant tumors throughout life. For many years, neoplasms associated with this disease were treated by surgical resection or ablation with the aim of reducing the risk of metastatic disease and controlling local or systemic sequelae. An effective systemic alternative could reduce the surgical burden and represents a new approach to oncological treatment.
Objective: To evaluate the efficacy and safety of different drugs used in the treatment of neoplasms associated with Von Hippel-Lindau disease. Search methods: An electronic search was carried out without language restriction, until July 31, 2024, in the Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, and SCIELO databases. Selection criteria: Clinical trials with patients with malignancies associated with Von Hippel-Lindau disease, and any targeted drug therapy as intervention were included. Data collection and analysis: Data from each clinical study were entered into a data table for qualitative analysis. Results: Five articles were selected, four of them are prospective studies and one is a retrospective study that evaluates the efficacy of treatment with Sunitinib, Dovitinib, Pazopanib, and Belzutifan. Conclusions: The inhibition of HIF-2? with Belzutifan presents a safer and more effective profile than the antiangiogenic agents Sunitinib and Pazopanib.
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| format | Article |
| id | doaj-art-9628c78f4eb8472c8be93d19d2cb20a6 |
| institution | OA Journals |
| issn | 1390-0110 2661-6653 |
| language | Spanish |
| publishDate | 2025-01-01 |
| publisher | Sociedad de Lucha contra el Cáncer-SOLCA |
| record_format | Article |
| series | Oncología |
| spelling | doaj-art-9628c78f4eb8472c8be93d19d2cb20a62025-08-20T02:03:00ZspaSociedad de Lucha contra el Cáncer-SOLCAOncología1390-01102661-66532025-01-0134310.33821/765Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión SistemáticaVeronica Hurtado Hurtado0Cristina Cabrera Mañay1Patricia Tamayo Aguilar2Clínica SantiagoHospital Los CeibosHospital SOLCA Background: Von Hippel-Lindau disease is an autosomal dominant syndrome characterized by the development of benign and malignant tumors throughout life. For many years, neoplasms associated with this disease were treated by surgical resection or ablation with the aim of reducing the risk of metastatic disease and controlling local or systemic sequelae. An effective systemic alternative could reduce the surgical burden and represents a new approach to oncological treatment. Objective: To evaluate the efficacy and safety of different drugs used in the treatment of neoplasms associated with Von Hippel-Lindau disease. Search methods: An electronic search was carried out without language restriction, until July 31, 2024, in the Cochrane Central Register of Controlled Trials (CENTRAL), PUBMED, and SCIELO databases. Selection criteria: Clinical trials with patients with malignancies associated with Von Hippel-Lindau disease, and any targeted drug therapy as intervention were included. Data collection and analysis: Data from each clinical study were entered into a data table for qualitative analysis. Results: Five articles were selected, four of them are prospective studies and one is a retrospective study that evaluates the efficacy of treatment with Sunitinib, Dovitinib, Pazopanib, and Belzutifan. Conclusions: The inhibition of HIF-2? with Belzutifan presents a safer and more effective profile than the antiangiogenic agents Sunitinib and Pazopanib. https://roe.solca.med.ec/index.php/johs/article/view/765Von Hippel- Lindau Diseasedrug therapybelzutifancarcinomarenal cellhemangioblastoma |
| spellingShingle | Veronica Hurtado Hurtado Cristina Cabrera Mañay Patricia Tamayo Aguilar Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión Sistemática Oncología Von Hippel- Lindau Disease drug therapy belzutifan carcinoma renal cell hemangioblastoma |
| title | Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión Sistemática |
| title_full | Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión Sistemática |
| title_fullStr | Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión Sistemática |
| title_full_unstemmed | Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión Sistemática |
| title_short | Tratamiento farmacológico de las neoplasias asociadas con la enfermedad de von Hippel-Lindau. Revisión Sistemática |
| title_sort | tratamiento farmacologico de las neoplasias asociadas con la enfermedad de von hippel lindau revision sistematica |
| topic | Von Hippel- Lindau Disease drug therapy belzutifan carcinoma renal cell hemangioblastoma |
| url | https://roe.solca.med.ec/index.php/johs/article/view/765 |
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