A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease
The current management of Alzheimer’s disease (AD) focuses on acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, although outcomes are not completely favorable. Hence, novel agents found in herbal plants are gaining attention as possible therapeutic alternatives. The Terminalia...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2016/8964849 |
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| _version_ | 1832559157521154048 |
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| author | Amir R. Afshari Hamid R. Sadeghnia Hamid Mollazadeh |
| author_facet | Amir R. Afshari Hamid R. Sadeghnia Hamid Mollazadeh |
| author_sort | Amir R. Afshari |
| collection | DOAJ |
| description | The current management of Alzheimer’s disease (AD) focuses on acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, although outcomes are not completely favorable. Hence, novel agents found in herbal plants are gaining attention as possible therapeutic alternatives. The Terminalia chebula (Family: Combretaceae) is a medicinal plant with a wide spectrum of medicinal properties and is reported to contain various biochemicals such as hydrolysable tannins, phenolic compounds, and flavonoids, so it may prove to be a good therapeutic alternative. In this research, we reviewed published scientific literature found in various databases: PubMed, Science Direct, Scopus, Web of Science, Scirus, and Google Scholar, with the keywords: T. chebula, AD, neuroprotection, medicinal plant, antioxidant, ellagitannin, gallotannin, gallic acid, chebulagic acid, and chebulinic acid. This review shows that T. chebula extracts and its constituents have AChEI and antioxidant and anti-inflammatory effects, all of which are currently relevant to the treatment of Alzheimer’s disease. |
| format | Article |
| id | doaj-art-962657b7737745babf214e403f5afb3c |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-962657b7737745babf214e403f5afb3c2025-02-03T01:30:48ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422016-01-01201610.1155/2016/89648498964849A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s DiseaseAmir R. Afshari0Hamid R. Sadeghnia1Hamid Mollazadeh2Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, IranPharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, IranNeurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, IranThe current management of Alzheimer’s disease (AD) focuses on acetylcholinesterase inhibitors (AChEIs) and NMDA receptor antagonists, although outcomes are not completely favorable. Hence, novel agents found in herbal plants are gaining attention as possible therapeutic alternatives. The Terminalia chebula (Family: Combretaceae) is a medicinal plant with a wide spectrum of medicinal properties and is reported to contain various biochemicals such as hydrolysable tannins, phenolic compounds, and flavonoids, so it may prove to be a good therapeutic alternative. In this research, we reviewed published scientific literature found in various databases: PubMed, Science Direct, Scopus, Web of Science, Scirus, and Google Scholar, with the keywords: T. chebula, AD, neuroprotection, medicinal plant, antioxidant, ellagitannin, gallotannin, gallic acid, chebulagic acid, and chebulinic acid. This review shows that T. chebula extracts and its constituents have AChEI and antioxidant and anti-inflammatory effects, all of which are currently relevant to the treatment of Alzheimer’s disease.http://dx.doi.org/10.1155/2016/8964849 |
| spellingShingle | Amir R. Afshari Hamid R. Sadeghnia Hamid Mollazadeh A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease Advances in Pharmacological Sciences |
| title | A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease |
| title_full | A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease |
| title_fullStr | A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease |
| title_full_unstemmed | A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease |
| title_short | A Review on Potential Mechanisms of Terminalia chebula in Alzheimer’s Disease |
| title_sort | review on potential mechanisms of terminalia chebula in alzheimer s disease |
| url | http://dx.doi.org/10.1155/2016/8964849 |
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