Regulation of Immune Cell Functions by Metabolic Reprogramming
Recent findings show that the metabolic status of immune cells can determine immune responses. Metabolic reprogramming between aerobic glycolysis and oxidative phosphorylation, previously speculated as exclusively observable in cancer cells, exists in various types of immune and stromal cells in man...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8605471 |
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| _version_ | 1832554721391411200 |
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| author | Jaehong Kim |
| author_facet | Jaehong Kim |
| author_sort | Jaehong Kim |
| collection | DOAJ |
| description | Recent findings show that the metabolic status of immune cells can determine immune responses. Metabolic reprogramming between aerobic glycolysis and oxidative phosphorylation, previously speculated as exclusively observable in cancer cells, exists in various types of immune and stromal cells in many different pathological conditions other than cancer. The microenvironments of cancer, obese adipose, and wound-repairing tissues share common features of inflammatory reactions. In addition, the metabolic changes in macrophages and T cells are now regarded as crucial for the functional plasticity of the immune cells and responsible for the progression and regression of many pathological processes, notably cancer. It is possible that metabolic changes in the microenvironment induced by other cellular components are responsible for the functional plasticity of immune cells. This review explores the molecular mechanisms responsible for metabolic reprogramming in macrophages and T cells and also provides a summary of recent updates with regard to the functional modulation of the immune cells by metabolic changes in the microenvironment, notably the tumor microenvironment. |
| format | Article |
| id | doaj-art-961da790dc6b4ae2b83b6f64c1678336 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-961da790dc6b4ae2b83b6f64c16783362025-02-03T05:50:49ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/86054718605471Regulation of Immune Cell Functions by Metabolic ReprogrammingJaehong Kim0Department of Biochemistry, School of Medicine, Gachon University, Incheon 21999, Republic of KoreaRecent findings show that the metabolic status of immune cells can determine immune responses. Metabolic reprogramming between aerobic glycolysis and oxidative phosphorylation, previously speculated as exclusively observable in cancer cells, exists in various types of immune and stromal cells in many different pathological conditions other than cancer. The microenvironments of cancer, obese adipose, and wound-repairing tissues share common features of inflammatory reactions. In addition, the metabolic changes in macrophages and T cells are now regarded as crucial for the functional plasticity of the immune cells and responsible for the progression and regression of many pathological processes, notably cancer. It is possible that metabolic changes in the microenvironment induced by other cellular components are responsible for the functional plasticity of immune cells. This review explores the molecular mechanisms responsible for metabolic reprogramming in macrophages and T cells and also provides a summary of recent updates with regard to the functional modulation of the immune cells by metabolic changes in the microenvironment, notably the tumor microenvironment.http://dx.doi.org/10.1155/2018/8605471 |
| spellingShingle | Jaehong Kim Regulation of Immune Cell Functions by Metabolic Reprogramming Journal of Immunology Research |
| title | Regulation of Immune Cell Functions by Metabolic Reprogramming |
| title_full | Regulation of Immune Cell Functions by Metabolic Reprogramming |
| title_fullStr | Regulation of Immune Cell Functions by Metabolic Reprogramming |
| title_full_unstemmed | Regulation of Immune Cell Functions by Metabolic Reprogramming |
| title_short | Regulation of Immune Cell Functions by Metabolic Reprogramming |
| title_sort | regulation of immune cell functions by metabolic reprogramming |
| url | http://dx.doi.org/10.1155/2018/8605471 |
| work_keys_str_mv | AT jaehongkim regulationofimmunecellfunctionsbymetabolicreprogramming |