Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates
A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl afforded diazonium salt derivatives 2 and 5, which were tr...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2018/3626824 |
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| author | Mohamed El-Naggar Abdel-Nasser El-Shorbagi Dina H. Elnaggar Abd El-Galil E. Amr Mohamed A. Al-Omar Elsayed A. Elsayed |
| author_facet | Mohamed El-Naggar Abdel-Nasser El-Shorbagi Dina H. Elnaggar Abd El-Galil E. Amr Mohamed A. Al-Omar Elsayed A. Elsayed |
| author_sort | Mohamed El-Naggar |
| collection | DOAJ |
| description | A series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl afforded diazonium salt derivatives 2 and 5, which were treated with substituted imino or substituted amino derivatives, to give the corresponding substituted amino-pent-2-en-3-yl-diazenylbenzoate 4a–k or 2-substituted-1-(naphthalen-1-yl)diazene derivatives 6a–h, 7a,b, and 8a,b. All the synthesized compounds were elucidated by elemental analysis and spectroscopic evidence. |
| format | Article |
| id | doaj-art-9612a04c7b5f4659a13a89065d373dd3 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-9612a04c7b5f4659a13a89065d373dd32025-02-03T05:43:42ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/36268243626824Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene CandidatesMohamed El-Naggar0Abdel-Nasser El-Shorbagi1Dina H. Elnaggar2Abd El-Galil E. Amr3Mohamed A. Al-Omar4Elsayed A. Elsayed5Chemistry Department, Faculty of Sciences, University of Sharjah, Sharjah 27272, UAECollege of Pharmacy, University of Sharjah, Sharjah 27272, UAEApplied Organic Chemistry Department, National Research Centre, Dokki, Giza 12622, EgyptDrug Exploration & Development Chair (DEDC), Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDrug Exploration & Development Chair (DEDC), Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaBioproducts Research Department, Zoology Department, Faculty of Science, King Saud University, Riyadh, Saudi ArabiaA series of azocompounds containing methyl salicylate 4a–k and 1-naphthyl moiety 6–8 was synthesized and tested as anticancer agents. Nitrosation of methyl 5-amino-2-hydroxybenzoate or 1-aminonaphthalene by using NaNO2 in the presence of HCl afforded diazonium salt derivatives 2 and 5, which were treated with substituted imino or substituted amino derivatives, to give the corresponding substituted amino-pent-2-en-3-yl-diazenylbenzoate 4a–k or 2-substituted-1-(naphthalen-1-yl)diazene derivatives 6a–h, 7a,b, and 8a,b. All the synthesized compounds were elucidated by elemental analysis and spectroscopic evidence.http://dx.doi.org/10.1155/2018/3626824 |
| spellingShingle | Mohamed El-Naggar Abdel-Nasser El-Shorbagi Dina H. Elnaggar Abd El-Galil E. Amr Mohamed A. Al-Omar Elsayed A. Elsayed Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates Journal of Chemistry |
| title | Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates |
| title_full | Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates |
| title_fullStr | Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates |
| title_full_unstemmed | Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates |
| title_short | Synthesis, Characterization, and Cytotoxic Evaluation of Some Newly Substituted Diazene Candidates |
| title_sort | synthesis characterization and cytotoxic evaluation of some newly substituted diazene candidates |
| url | http://dx.doi.org/10.1155/2018/3626824 |
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