Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China
Rhinitis is one of the most common respiratory diseases, influenced by various environmental factors such as green space, air pollution and indoor microbiomes. However, their interactions and combined effects have not been reported. We recruited 1121 preschool children from day care centers in a nor...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014765132401738X |
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| author | Liu Yang Huiyu Gao Ying Wang Dan Norbäck Zhuohui Zhao Xi Fu Yu Sun Xin Zhang |
| author_facet | Liu Yang Huiyu Gao Ying Wang Dan Norbäck Zhuohui Zhao Xi Fu Yu Sun Xin Zhang |
| author_sort | Liu Yang |
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| description | Rhinitis is one of the most common respiratory diseases, influenced by various environmental factors such as green space, air pollution and indoor microbiomes. However, their interactions and combined effects have not been reported. We recruited 1121 preschool children from day care centers in a northern city of China. Health and demographic data were collected through questionnaires answered by the children’s parents. Surrounding green space was assessed by Normalized Difference Vegetation Index (NDVI), Enhanced Vegetation Index (EVI) and land cover data of grassland proportion within 1500/3000 m. Ambient air pollution was estimated using the inverse distance weighted (IDW), and the indoor microbiome in classroom vacuum dust was profiled by bacterial 16S rRNA and fungal ITS amplicon sequencing. Mixed-effect logistic regression revealed the proportion of natural grassland, grassland leaf-off and total grassland was negatively associated with current rhinitis. Stratified analysis indicated that greater green space exposure was associated with a reduced current rhinitis in children at high levels of air pollution. Additionally, grassland also protects children against environmental tobacco smoke at home. Indoor microbiome analysis showed Haemophilus and Dolosigranulum were enriched in low-rhinitis day care centers, while Amaricoccus, Blautia and Mycosphaerella were enriched in high-rhinitis day care centers. Mediation analysis indicated that the indoor microbiome did not have significant mediating effects on the relationship between green space and children’s current rhinitis. This is the first study to reveal interactions of green space, air pollution and indoor microbiome on rhinitis, providing new insights into how environmental factors collectively influence respiratory health in children. |
| format | Article |
| id | doaj-art-95f163cfe712439aa296b3062a7a5fbd |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-95f163cfe712439aa296b3062a7a5fbd2025-01-23T05:26:01ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117662Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern ChinaLiu Yang0Huiyu Gao1Ying Wang2Dan Norbäck3Zhuohui Zhao4Xi Fu5Yu Sun6Xin Zhang7Institute of Environmental Science, Shanxi University, Taiyuan 030006, ChinaInstitute of Environmental Science, Shanxi University, Taiyuan 030006, ChinaInstitute of Environmental Science, Shanxi University, Taiyuan 030006, ChinaDepartment of Occupational and Environmental Medicine, Uppsala University Hospital, Uppsala 751 85, SwedenDepartment of Environmental Health, School of Public Health, NHC Key Laboratory of Health, China; Key Laboratory of Public Health Safety of the Ministry of Education, Shanghai Typhoon Institute, CMA, Shanghai Key Laboratory of Meteorology and Health, Shanghai 200030, China; IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Climate Extremes Impact and Public Health, Fudan University, Shanghai 200438, ChinaSchool of Public Health, Guangdong Pharmaceutical University, Guangzhou 510006, China; Guangdong Provincial Engineering Research Center of Public Health Detection and Assessment, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China; Corresponding author at: Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University, Guangzhou 510642, China.Institute of Environmental Science, Shanxi University, Taiyuan 030006, China; Corresponding author.Rhinitis is one of the most common respiratory diseases, influenced by various environmental factors such as green space, air pollution and indoor microbiomes. However, their interactions and combined effects have not been reported. We recruited 1121 preschool children from day care centers in a northern city of China. Health and demographic data were collected through questionnaires answered by the children’s parents. Surrounding green space was assessed by Normalized Difference Vegetation Index (NDVI), Enhanced Vegetation Index (EVI) and land cover data of grassland proportion within 1500/3000 m. Ambient air pollution was estimated using the inverse distance weighted (IDW), and the indoor microbiome in classroom vacuum dust was profiled by bacterial 16S rRNA and fungal ITS amplicon sequencing. Mixed-effect logistic regression revealed the proportion of natural grassland, grassland leaf-off and total grassland was negatively associated with current rhinitis. Stratified analysis indicated that greater green space exposure was associated with a reduced current rhinitis in children at high levels of air pollution. Additionally, grassland also protects children against environmental tobacco smoke at home. Indoor microbiome analysis showed Haemophilus and Dolosigranulum were enriched in low-rhinitis day care centers, while Amaricoccus, Blautia and Mycosphaerella were enriched in high-rhinitis day care centers. Mediation analysis indicated that the indoor microbiome did not have significant mediating effects on the relationship between green space and children’s current rhinitis. This is the first study to reveal interactions of green space, air pollution and indoor microbiome on rhinitis, providing new insights into how environmental factors collectively influence respiratory health in children.http://www.sciencedirect.com/science/article/pii/S014765132401738XGreen spaceAir pollutionIndoor microbiomeRhinitisPreschool children |
| spellingShingle | Liu Yang Huiyu Gao Ying Wang Dan Norbäck Zhuohui Zhao Xi Fu Yu Sun Xin Zhang Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China Ecotoxicology and Environmental Safety Green space Air pollution Indoor microbiome Rhinitis Preschool children |
| title | Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China |
| title_full | Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China |
| title_fullStr | Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China |
| title_full_unstemmed | Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China |
| title_short | Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China |
| title_sort | environmental impacts on childhood rhinitis the role of green spaces air pollutants and indoor microbial communities in taiyuan a city in northern china |
| topic | Green space Air pollution Indoor microbiome Rhinitis Preschool children |
| url | http://www.sciencedirect.com/science/article/pii/S014765132401738X |
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