Melatonin and Ischemic Stroke: Mechanistic Roles and Action
Stroke is one of the most devastating neurological disabilities and brain’s vulnerability towards it proves to be fatal and socio-economic loss of millions of people worldwide. Ischemic stroke remains at the center stage of it, because of its prevalence amongst the several other types attacking the...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2015/384750 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564135090454528 |
|---|---|
| author | Syed Suhail Andrabi Suhel Parvez Heena Tabassum |
| author_facet | Syed Suhail Andrabi Suhel Parvez Heena Tabassum |
| author_sort | Syed Suhail Andrabi |
| collection | DOAJ |
| description | Stroke is one of the most devastating neurological disabilities and brain’s vulnerability towards it proves to be fatal and socio-economic loss of millions of people worldwide. Ischemic stroke remains at the center stage of it, because of its prevalence amongst the several other types attacking the brain. The various cascades of events that have been associated with stroke involve oxidative stress, excitotoxicity, mitochondrial dysfunction, upregulation of Ca2+ level, and so forth. Melatonin is a neurohormone secreted by pineal and extra pineal tissues responsible for various physiological processes like sleep and mood behaviour. Melatonin has been implicated in various neurological diseases because of its antioxidative, antiapoptotic, and anti-inflammatory properties. We have previously reviewed the neuroprotective effect of melatonin in various models of brain injury like traumatic brain injury and spinal cord injury. In this review, we have put together the various causes and consequence of stroke and protective role of melatonin in ischemic stroke. |
| format | Article |
| id | doaj-art-95eac0225fac479b8aee275a8aade7b9 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-95eac0225fac479b8aee275a8aade7b92025-02-03T01:11:46ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422015-01-01201510.1155/2015/384750384750Melatonin and Ischemic Stroke: Mechanistic Roles and ActionSyed Suhail Andrabi0Suhel Parvez1Heena Tabassum2Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, IndiaDepartment of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, IndiaDepartment of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110062, IndiaStroke is one of the most devastating neurological disabilities and brain’s vulnerability towards it proves to be fatal and socio-economic loss of millions of people worldwide. Ischemic stroke remains at the center stage of it, because of its prevalence amongst the several other types attacking the brain. The various cascades of events that have been associated with stroke involve oxidative stress, excitotoxicity, mitochondrial dysfunction, upregulation of Ca2+ level, and so forth. Melatonin is a neurohormone secreted by pineal and extra pineal tissues responsible for various physiological processes like sleep and mood behaviour. Melatonin has been implicated in various neurological diseases because of its antioxidative, antiapoptotic, and anti-inflammatory properties. We have previously reviewed the neuroprotective effect of melatonin in various models of brain injury like traumatic brain injury and spinal cord injury. In this review, we have put together the various causes and consequence of stroke and protective role of melatonin in ischemic stroke.http://dx.doi.org/10.1155/2015/384750 |
| spellingShingle | Syed Suhail Andrabi Suhel Parvez Heena Tabassum Melatonin and Ischemic Stroke: Mechanistic Roles and Action Advances in Pharmacological Sciences |
| title | Melatonin and Ischemic Stroke: Mechanistic Roles and Action |
| title_full | Melatonin and Ischemic Stroke: Mechanistic Roles and Action |
| title_fullStr | Melatonin and Ischemic Stroke: Mechanistic Roles and Action |
| title_full_unstemmed | Melatonin and Ischemic Stroke: Mechanistic Roles and Action |
| title_short | Melatonin and Ischemic Stroke: Mechanistic Roles and Action |
| title_sort | melatonin and ischemic stroke mechanistic roles and action |
| url | http://dx.doi.org/10.1155/2015/384750 |
| work_keys_str_mv | AT syedsuhailandrabi melatoninandischemicstrokemechanisticrolesandaction AT suhelparvez melatoninandischemicstrokemechanisticrolesandaction AT heenatabassum melatoninandischemicstrokemechanisticrolesandaction |