Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in Tablets
The objective of present study was to develop and validate an analytical method for quantitative determination and dissolution studies of glimepiride in tablets. The glimepiride shows absorption maxima at 225 nm and obeyed Beer's law in the range of 6.0 – 14.0 µg/mL. The limit of detection and...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/856130 |
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| author | Madhusudhanareddy Induri Bhagavan Raju M. Rajendra Prasad Y. Pavankumar Reddy K. |
| author_facet | Madhusudhanareddy Induri Bhagavan Raju M. Rajendra Prasad Y. Pavankumar Reddy K. |
| author_sort | Madhusudhanareddy Induri |
| collection | DOAJ |
| description | The objective of present study was to develop and validate an analytical method for quantitative determination and dissolution studies of glimepiride in tablets. The glimepiride shows absorption maxima at 225 nm and obeyed Beer's law in the range of 6.0 – 14.0 µg/mL. The limit of detection and limit of quantitation were 0.06, and 0.17 µg/mL respectively. Percentage recovery of glimepiride for the proposed method ranged from 99.32 to 100.98% indicating no interference of the tablet excipients. It was concluded that the proposed method is simple, easy to apply, economical and used as an alternative to the existing spectrophotometric and non-spectrophotometric methods for the routine analysis of glimepiride in pharmaceutical formulations and in vitro dissolution studies. |
| format | Article |
| id | doaj-art-95d29289740b4c479b74dbc2e1192a04 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-95d29289740b4c479b74dbc2e1192a042025-02-03T01:22:32ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-019299399810.1155/2012/856130Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in TabletsMadhusudhanareddy Induri0Bhagavan Raju M.1Rajendra Prasad Y.2Pavankumar Reddy K.3Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad 500014, IndiaDepartment of Pharmaceutical Chemistry, C.M. College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad 500014, IndiaDepartment of Pharmaceutical Chemistry, A. U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530003, Andhra Pradesh, IndiaDepartment of Pharmaceutical Chemistry, C.M. College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad 500014, IndiaThe objective of present study was to develop and validate an analytical method for quantitative determination and dissolution studies of glimepiride in tablets. The glimepiride shows absorption maxima at 225 nm and obeyed Beer's law in the range of 6.0 – 14.0 µg/mL. The limit of detection and limit of quantitation were 0.06, and 0.17 µg/mL respectively. Percentage recovery of glimepiride for the proposed method ranged from 99.32 to 100.98% indicating no interference of the tablet excipients. It was concluded that the proposed method is simple, easy to apply, economical and used as an alternative to the existing spectrophotometric and non-spectrophotometric methods for the routine analysis of glimepiride in pharmaceutical formulations and in vitro dissolution studies.http://dx.doi.org/10.1155/2012/856130 |
| spellingShingle | Madhusudhanareddy Induri Bhagavan Raju M. Rajendra Prasad Y. Pavankumar Reddy K. Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in Tablets E-Journal of Chemistry |
| title | Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in Tablets |
| title_full | Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in Tablets |
| title_fullStr | Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in Tablets |
| title_full_unstemmed | Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in Tablets |
| title_short | Development and Validation of a Spectrophotometric Method for Quantification and Dissolution Studies of Glimepiride in Tablets |
| title_sort | development and validation of a spectrophotometric method for quantification and dissolution studies of glimepiride in tablets |
| url | http://dx.doi.org/10.1155/2012/856130 |
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